Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Paul R. Bruzinski"'
Autor:
Mark A Helle, Mark A. Wolf, Brian P. Haney, Qiang Yang, Cheng Guo, Bernhard J. Paul, Lingling Wang, Daniel K. Keefe, Paul R. Bruzinski, Nathan T. Reynolds, Mark A. Mortensen, Nicole L. Malinowski
Publikováno v:
Organic Process Research & Development. 16:1811-1817
Process development and production of a novel tubulin inhibitor are described. The desired API was obtained through selective iodination of the 12′ position of vinblastine and subsequent thiomethylation. Most of the impurities were identified, and
Publikováno v:
Tetrahedron Letters. 38:1741-1744
Allylsilanes or benzylsilanes of high enantiomeric purity (77–95% ee) are formed from the rhodium(II) (S)-N-[p-(dodecylphenyl)sulfonyl]prolinate ( 1 ) catalyzed decomposition of vinyldiazomethanes or phenyldiazomethanes in the presence of dimethylp
Publikováno v:
Tetrahedron Letters. 37:4133-4136
Rhodium(II) (S)-N-(arylsulfonyl)prolinate catalyzed decomposition of diazoalkanes containing a methyl ester and either a vinyl or a phenyl group in the presence of alkenes results in highly diastereoselective and enantioselective cyclopropanations.
Publikováno v:
Journal of the American Chemical Society. 118:6897-6907
The rhodium N-(arylsulfonyl)prolinate catalyzed decomposition of vinyldiazomethanes in the presence of alkenes leads to a very general method for the synthesis of functionalized cyclopropanes in a highly diastereoselective and enantioselective mode.
Publikováno v:
The Journal of Organic Chemistry. 59:4535-4541
Rhodium(II)-stabilized vinylcarbenoid intermediates display electrophilic character at both the carbenoid site and the vinylogous position. The solvent and catalyst as well as the vinylcarbenoid structure have major effects on the regiochemical outco
Publikováno v:
ChemInform. 26
Rhodium(II)-stabilized vinylcarbenoid intermediates display electrophilic character at both the carbenoid site and the vinylogous position. The solvent and catalyst as well as the vinylcarbenoid structure have major effects on the regiochemical outco
Publikováno v:
ChemInform. 27
Publikováno v:
ChemInform. 28
Publikováno v:
ChemInform. 27