Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Paul R V, Johnson"'
Publikováno v:
Bioengineering, Vol 11, Iss 8, p 828 (2024)
Throughout the isolation process, human islets are subjected to destruction of the islet basement membrane (BM) and reduced oxygen supply. Reconstruction of the BM represents an option to improve islet function and survival post-transplant and may pa
Externí odkaz:
https://doaj.org/article/579c418e49024012a00e0dc443ce15ce
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract The impact of ischaemia can severely damage procured donor organs for transplantation. The pancreas, and pancreatic islets in particular, is one of the most sensitive tissues towards hypoxia. The present study was aimed to assess the effect
Externí odkaz:
https://doaj.org/article/b41a0d285bae4a7c966ca4bef69d2c1c
Publikováno v:
BMJ Paediatrics Open, Vol 6, Iss 1 (2022)
Objective To establish short-term and medium-term complications 1-year postdiagnosis, of acute pancreatitis (AP) in children aged 0–14 years.Design One-year follow-up of a prospective monthly surveillance of new cases of AP in children under 15 yea
Externí odkaz:
https://doaj.org/article/f89500a97cc24e6ebf0099b5794abe36
Autor:
Rebecca M. Spiers, Sarah E. Cross, Helen L. Brown, Paul A. Bateman, Rebecca H. Vaughan, Stephen J. Hughes, Paul R. V. Johnson
Publikováno v:
Cell Transplantation, Vol 27 (2018)
Despite huge advances in the field of islet transplantation over the last two decades, current islet isolation methods remain suboptimal, with transplantable yields obtained in less than half of all pancreases processed worldwide. Successful islet is
Externí odkaz:
https://doaj.org/article/bd24ca095ad546338fcb70a23cf79b01
Publikováno v:
Cell Transplantation, Vol 26 (2017)
Efficient islet release from the pancreas requires the combination of collagenase, neutral protease (cNP), or thermolysin (TL). Recently, it has been shown that clostripain (CP) may also contribute to efficient islet release from the human pancreas.
Externí odkaz:
https://doaj.org/article/a97a0609a26442ef9eda70c0e7482c2c
Autor:
Daniel Brandhorst, Géraldine Parnaud, Andrew Friberg, Vanessa Lavallard, Sandrine Demuylder-Mischler, Stephen Hughes, Julia Saphörster, Manfred Kurfürst, Olle Korsgren, Thierry Berney, Paul R. V. Johnson
Publikováno v:
Cell Transplantation, Vol 26 (2017)
Animal-free (AF) SERVA Collagenase AF-1 and Neutral Protease (NP) AF GMP Grade have recently become available for human islet isolation. This report describes the initial experiences of 3 different islet transplant centers. Thirty-four human pancreas
Externí odkaz:
https://doaj.org/article/b3c2324601ed460886948968e4bb0bbd
Publikováno v:
BMJ paediatrics open. 6(1)
ObjectiveTo establish short-term and medium-term complications 1-year postdiagnosis, of acute pancreatitis (AP) in children aged 0–14 years.DesignOne-year follow-up of a prospective monthly surveillance of new cases of AP in children under 15 years
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::628fb2e881b008493aa4d694ede14fc0
https://pubmed.ncbi.nlm.nih.gov/36053577
https://pubmed.ncbi.nlm.nih.gov/36053577
Publikováno v:
Cell Transplantation, Vol 25 (2016)
Hypoxia is the main threat to morphological and functional integrity of isolated pancreatic islets. Lack of oxygen seems to be of particular importance for functionality of encapsulated islets. The present study was initiated as an experimental model
Externí odkaz:
https://doaj.org/article/b347001576fd4529ab253b32adaed111
Autor:
Leo P. Graves, Mine Aksular, Riyadh A. Alakeely, Daniel Ruiz Buck, Adam C. Chambers, Fernanda Murguia-Meca, Juan-Jose Plata-Muñoz, Stephen Hughes, Paul R. V. Johnson, Robert D. Possee, Linda A. King
Publikováno v:
Viruses, Vol 10, Iss 10, p 574 (2018)
Pancreatic islet transplantation is a promising treatment for type 1 diabetes mellitus offering improved glycaemic control by restoring insulin production. Improved human pancreatic islet isolation has led to higher islet transplantation success. How
Externí odkaz:
https://doaj.org/article/3b93936f17a647c799bf5232c11679bf
Publikováno v:
PLoS ONE, Vol 10, Iss 1, p e0116908 (2015)
To identify methods of improving the evidence base in smaller surgical specialties, using a systematic review of gastroschisis management as an example.Operative primary fascial closure (OPFC), and silo placement with staged reduction and delayed clo
Externí odkaz:
https://doaj.org/article/1ac3c1ef87db4240814b4f0292540112