Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Paul R Caron"'
Autor:
Bambang S Adiwijaya, Eva Herrmann, Brian Hare, Tara Kieffer, Chao Lin, Ann D Kwong, Varun Garg, John C R Randle, Christoph Sarrazin, Stefan Zeuzem, Paul R Caron
Publikováno v:
PLoS Computational Biology, Vol 6, Iss 4, p e1000745 (2010)
Variants resistant to compounds specifically targeting HCV are observed in clinical trials. A multi-variant viral dynamic model was developed to quantify the evolution and in vivo fitness of variants in subjects dosed with monotherapy of an HCV prote
Externí odkaz:
https://doaj.org/article/aae165b76f2a4ad9bcccbb9fba06fbf0
Autor:
John C. R. Randle, Avidan U. Neumann, Brian Hare, Hendrik W. Reesink, Paul R. Caron, Eva Herrmann, Bambang S. Adiwijaya, Stefan Zeuzem
Publikováno v:
Antiviral therapy, 14(4), 591-595. International Medical Press Ltd
Background Telaprevir (TVR) is a hepatitis C virus (HCV) NS3.4A protease inhibitor that has exhibited antiviral activity in patients with HCV genotype 1 infection. The viral dynamics in patients dosed with TVR were compared with those reported for pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34c23e7cb178b1668ce7592cf62fee93
https://doi.org/10.1177/135965350901400402
https://doi.org/10.1177/135965350901400402
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 70:1451-1460
We report a clustering of public human protein kinase structures based on the conformations of two structural elements, the activation segment and the C-helix, revealing three discrete clusters. One cluster includes kinases in catalytically active co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae601148fda2d9b2fbae66af7fde302c
https://doi.org/10.1002/prot.21633
https://doi.org/10.1002/prot.21633
Autor:
Michael D. Sintchak, Paul R. Caron, Scott A. Raybuck, Elmar Nimmesgern, Maureen T. DeCenzo, David J. Livingston, Olga Futer
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1594:27-39
The oxidation of IMP to XMP is the rate-limiting step in the de novo synthesis of guanine ribonucleotides. This NAD-dependent reaction is catalyzed by the enzyme inosine monophosphate dehydrogenase (IMPDH). Based upon the recent structural determinat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcd1edb7c5e7fba51eef2ff10de7d552
https://doi.org/10.1016/s0167-4838(01)00277-1
https://doi.org/10.1016/s0167-4838(01)00277-1
Autor:
Mark A. Fleming, William Markland, Yong Gu, Joyce T. Coll, Paul R. Caron, Wilson Keith P, Ted Fox, Xiaoling Xie, Michael S-S Su
Publikováno v:
Structure. 6(8):983-991
Background: The c-Jun N-terminal kinases (JNKs) are members of the mitogen-activated protein (MAP) kinase family, and regulate signal transduction in response to environmental stress. Activation and nuclear localization of JNK3, a neuronal-specific i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b58a6f1538ecefa95325b44908c9920e
Autor:
Paul R. Caron, James P. Griffith, John A. Thomson, Morgenstern Kurt A, Joseph L. Kim, Maureen D. Dwyer, Murcko Mark A, Chao Lin
Publikováno v:
Structure. 6:89-100
Background: Hepatitis C virus (HCV) represents a major health concern as it is responsible for a significant number of hepatitis cases worldwide. Much research has focused on the replicative enzymes of HCV as possible targets for more effective thera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dea470dadb039a4d278c0fdad619aa6c
https://doi.org/10.1016/s0969-2126(98)00010-0
https://doi.org/10.1016/s0969-2126(98)00010-0
Autor:
Alastair Aitken, Stefano Volinia, Stephen J. Smerdon, Henrik Leffers, Michael B. Yaffe, Lewis C. Cantley, Paul R. Caron, Steven J. Gamblin, Katrin Rittinger
Publikováno v:
Cell. 91:961-971
The 14-3-3 family of proteins mediates signal transduction by binding to phosphoserine-containing proteins. Using phosphoserine-oriented peptide libraries to probe all mammalian and yeast 14-3-3s, we identified two different binding motifs, RSXpSXP a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a4fea091e2fda869cb8c6e5ec09ba5b
https://doi.org/10.1016/s0092-8674(00)80487-0
https://doi.org/10.1016/s0092-8674(00)80487-0
Autor:
James P. Griffith, Michael S.-S. Su, Paul R. Caron, Stephen P. Chambers, Matthew J. Fitzgibbon, Wenyong Chen, Wilson Keith P, Patricia G. McCaffrey
Publikováno v:
Journal of Biological Chemistry. 271:27696-27700
p38 mitogen-activated protein kinase is activated by environmental stress and cytokines and plays a role in transcriptional regulation and inflammatory responses. The crystal structure of the apo, unphosphorylated form of p38 kinase has been solved a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c4d04f49f0551ca46aeae941e390859
https://doi.org/10.1074/jbc.271.44.27696
https://doi.org/10.1074/jbc.271.44.27696
Publikováno v:
Journal of Biological Chemistry. 271:17469-17475
Biochemical and genetic experiments were carried out to deduce the structural and functional domains of SopB protein involved in the equipartition of F plasmid. The protein is dimeric. Proteolytic and chemical footprinting studies support earlier gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a5db2d4e9e2328f46d089e88b78949c
https://doi.org/10.1074/jbc.271.29.17469
https://doi.org/10.1074/jbc.271.29.17469
Publikováno v:
Proceedings of the National Academy of Sciences. 92:2667-2671
The yeast TOP3 gene, encoding DNA topoisomerase III, and EST1 gene, encoding a putative telomerase, are shown to be abutted head-to-head on chromosome XII, with the two initiation codons separated by 258 bp. This arrangement suggests that the two gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c70fe63c80e303dddf5883e72c4e685a
https://doi.org/10.1073/pnas.92.7.2667
https://doi.org/10.1073/pnas.92.7.2667