Zobrazeno 1 - 10
of 252
pro vyhledávání: '"Paul R, Thompson"'
Autor:
Alok K. Mishra, Tianyi Ye, Shahid Banday, Ritesh P. Thakare, Chinh Tran-To Su, Ngoc N.H. Pham, Amjad Ali, Ankur Kulshreshtha, Shreya Roy Chowdhury, Tessa M. Simone, Kai Hu, Lihua Julie Zhu, Birgit Eisenhaber, Sara K. Deibler, Karl Simin, Paul R. Thompson, Michelle A. Kelliher, Frank Eisenhaber, Sunil K. Malonia, Michael R. Green
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114041- (2024)
Summary: CD24 is frequently overexpressed in ovarian cancer and promotes immune evasion by interacting with its receptor Siglec10, present on tumor-associated macrophages, providing a “don’t eat me” signal that prevents targeting and phagocytos
Externí odkaz:
https://doaj.org/article/51c10ad4e53242b1b570a3e817e3e103
Publikováno v:
Neurobiology of Disease, Vol 192, Iss , Pp 106414- (2024)
Alteration in protein citrullination (PC), a common posttranslational modification (PTM), contributes to pathogenesis in various inflammatory disorders. We previously reported that PC and protein arginine deiminase 2 (PAD2), the predominant enzyme is
Externí odkaz:
https://doaj.org/article/1f63fc7b49e34dcb88a7edb501c4a3da
Autor:
Selina Pasquero, Francesca Gugliesi, Matteo Biolatti, Valentina Dell'Oste, Camilla Albano, Greta Bajetto, Gloria Griffante, Linda Trifirò, Bianca Brugo, Stefano Raviola, Davide Lacarbonara, Qiao Yang, Sen Sudeshna, Leonard Barasa, Hafeez Haniff, Paul R Thompson, Santo Landolfo, Marco De Andrea
Publikováno v:
PLoS Pathogens, Vol 19, Iss 12, p e1011849 (2023)
Herpes simplex virus 1 (HSV-1) is a neurotropic virus that remains latent in neuronal cell bodies but reactivates throughout an individual's life, causing severe adverse reactions, such as herpes simplex encephalitis (HSE). Recently, it has also been
Externí odkaz:
https://doaj.org/article/9ab133fae77743a9b39e0c3aef5aae35
Autor:
Benjamin Geary, Bo Sun, Ronak R. Tilvawala, Leonard Barasa, Konstantin Tsoyi, Ivan O. Rosas, Paul R. Thompson, I-Cheng Ho
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionMZB1 is an endoplasmic reticulum residential protein preferentially expressed in plasma cells, marginal zone and B1 B cells. Recent studies on murine B cells show that it interacts with the tail piece of IgM and IgA heavy chain and promot
Externí odkaz:
https://doaj.org/article/0f632f4a17544d1c856c41d9b7d4644c
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-22 (2022)
Abstract Increased protein citrullination (PC) and dysregulated protein arginine deiminase (PAD) activity have been observed in several neurodegenerative diseases. PC is a posttranslational modification catalyzed by the PADs. PC converts peptidyl-arg
Externí odkaz:
https://doaj.org/article/083dc76ee24a464f8efb4c4ded95b115
Autor:
Gloria Griffante, Francesca Gugliesi, Selina Pasquero, Valentina Dell’Oste, Matteo Biolatti, Ari J. Salinger, Santanu Mondal, Paul R. Thompson, Eranthie Weerapana, Robert J. Lebbink, Jasper A. Soppe, Thomas Stamminger, Virginie Girault, Andreas Pichlmair, Gábor Oroszlán, Donald M. Coen, Marco De Andrea, Santo Landolfo
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Citrullination is a posttranslational modification of arginines. Here, the authors show that HCMV infection increases citrullination of host and virus proteins to promote infection and that citrullinated interferon-inducible protein IFIT1 is impaired
Externí odkaz:
https://doaj.org/article/d9f89f1cfaed42dc92c156e171d58d7e
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Citrullination of arginine is crucial for several physiological processes. Here the authors report the site-specific incorporation of citrulline into proteins in mammalian cells using an engineered tRNA synthetase/tRNA pair and a photocaged-citrullin
Externí odkaz:
https://doaj.org/article/bd9c1f5a80e24b4ca721bf1b4716c16e
Autor:
Nicholas D Peterson, Janneke D Icso, J Elizabeth Salisbury, Tomás Rodríguez, Paul R Thompson, Read Pukkila-Worley
Publikováno v:
eLife, Vol 11 (2022)
Intracellular signaling regulators can be concentrated into membrane-free, higher ordered protein assemblies to initiate protective responses during stress — a process known as phase transition. Here, we show that a phase transition of the Caenorha
Externí odkaz:
https://doaj.org/article/bb184548228d48e2b33d843463905a40
Autor:
María Teresa Martín Monreal, Alexandra Stripp Rebak, Laura Massarenti, Santanu Mondal, Ladislav Šenolt, Niels Ødum, Michael L. Nielsen, Paul R. Thompson, Claus H. Nielsen, Dres Damgaard
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Citrullination, the conversion of peptidyl-arginine into peptidyl-citrulline, is involved in the breakage of self-tolerance in anti-CCP-positive rheumatoid arthritis. This reaction is catalyzed by peptidyl arginine deiminases (PADs), of which PAD2 an
Externí odkaz:
https://doaj.org/article/765ada75d6dd4858b2ec1a59679ed1e7
Autor:
Fujun Li, Lixia Miao, Teng Xue, Hao Qin, Santanu Mondal, Paul R. Thompson, Scott A. Coonrod, Xiaoqiu Liu, Xuesen Zhang
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-15 (2019)
Abstract Background Tamoxifen resistance presents a huge clinical challenge for breast cancer patients. An understanding of the mechanisms of tamoxifen resistance can guide development of efficient therapies to prevent drug resistance. Methods We fir
Externí odkaz:
https://doaj.org/article/6c44e0ffa4a54d8b85e40b8a3d3716e5