Zobrazeno 1 - 10
of 145
pro vyhledávání: '"Paul Polakis"'
Autor:
Josefa Dela Cruz Chuh, MaryAnn Go, Yvonne Chen, Jun Guo, Hanine Rafidi, Danielle Mandikian, Yonglian Sun, Zhonghua Lin, Kellen Schneider, Pamela Zhang, Rajesh Vij, Danielle Sharpnack, Pamela Chan, Cecile de la Cruz, Jack Sadowsky, Dhaya Seshasayee, James T. Koerber, Thomas H. Pillow, Gail D. Phillips, Rebecca K Rowntree, C. Andrew Boswell, Katherine R. Kozak, Andrew G. Polson, Paul Polakis, Shang-Fan Yu, Peter S. Dragovich, Nicholas J. Agard
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
Early success with brentuximab vedotin in treating classical Hodgkin lymphoma spurred an influx of at least 20 monomethyl auristatin E (MMAE) antibody-drug conjugates (ADCs) into clinical trials. While three MMAE-ADCs have been approved, most of thes
Externí odkaz:
https://doaj.org/article/25ec46df098b446591f757fd46270d3e
Autor:
Travis W Bainbridge, Venita I DeAlmeida, Anita Izrael-Tomasevic, Cécile Chalouni, Borlan Pan, Joshua Goldsmith, Alia P Schoen, Gabriel A Quiñones, Ryan Kelly, Jennie R Lill, Wendy Sandoval, Mike Costa, Paul Polakis, David Arnott, Bonnee Rubinfeld, James A Ernst
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102695 (2014)
Receptor tyrosine kinase-like orphan receptors (ROR) 1 and 2 are atypical members of the receptor tyrosine kinase (RTK) family and have been associated with several human diseases. The vertebrate RORs contain an ATP binding domain that deviates from
Externí odkaz:
https://doaj.org/article/080290e22e094a90849ffe90a71ec97c
Autor:
Marinella G Callow, Hoanh Tran, Lilian Phu, Ted Lau, James Lee, Wendy N Sandoval, Peter S Liu, Sheila Bheddah, Janet Tao, Jennie R Lill, Jo-Anne Hongo, David Davis, Donald S Kirkpatrick, Paul Polakis, Mike Costa
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22595 (2011)
Canonical Wnt signaling is controlled intracellularly by the level of β-catenin protein, which is dependent on Axin scaffolding of a complex that phosphorylates β-catenin to target it for ubiquitylation and proteasomal degradation. This function of
Externí odkaz:
https://doaj.org/article/dd787cda777a424996475d2d515fd403
Autor:
Bob Y Liu, Irina Soloviev, Peter Chang, John Lee, XiaoDong Huang, Cuiling Zhong, Napoleone Ferrara, Paul Polakis, Chie Sakanaka
Publikováno v:
PLoS ONE, Vol 5, Iss 1, p e8611 (2010)
BACKGROUND: Histological examinations of MMTV-Wnt1 tumors reveal drastic differences in the tumor vasculature when compared to MMTV-Her2 tumors. However, these differences have not been formally described, nor have any angiogenic factors been implica
Externí odkaz:
https://doaj.org/article/66c5507710c64344a06eaa2e53605330
Autor:
Yan Gong, Eric Bourhis, Cecilia Chiu, Scott Stawicki, Venita I DeAlmeida, Bob Y Liu, Khanhky Phamluong, Tim C Cao, Richard A D Carano, James A Ernst, Mark Solloway, Bonnee Rubinfeld, Rami N Hannoush, Yan Wu, Paul Polakis, Mike Costa
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12682 (2010)
β-Catenin-dependent Wnt signaling is initiated as Wnt binds to both the receptor FZD and coreceptor LRP5/6, which then assembles a multimeric complex at the cytoplasmic membrane face to recruit and inactivate the kinase GSK3. The large number and se
Externí odkaz:
https://doaj.org/article/e5991f379a5147a2b9b70b45b9ce3556
Autor:
Nathan T Morrell, Philipp Leucht, Ludan Zhao, Jae-Beom Kim, Derk ten Berge, Karthik Ponnusamy, A Lyonel Carre, Henryk Dudek, Marie Zachlederova, Michael McElhaney, Shirley Brunton, Janet Gunzner, Marinella Callow, Paul Polakis, Mike Costa, Xiaoyan M Zhang, Jill A Helms, Roel Nusse
Publikováno v:
PLoS ONE, Vol 3, Iss 8, p e2930 (2008)
Wnt signals exercise strong cell-biological and regenerative effects of considerable therapeutic value. There are, however, no specific Wnt agonists and no method for in vivo delivery of purified Wnt proteins. Wnts contain lipid adducts that are requ
Externí odkaz:
https://doaj.org/article/9d6786461d08499396af9c7a5f3c0bb3
Publikováno v:
PLoS ONE, Vol 3, Iss 5, p e2186 (2008)
Although Wnt signaling has been shown to be important for embryonic morphogenesis and cancer pathogenesis of several tissues, its role in prostatic development and tumorigenesis is not well understood. Here we show that Wnt signaling regulated prosta
Externí odkaz:
https://doaj.org/article/c2b46ed2fc8d46ba9399cc5abcfac684
PDF file - 55KB, normal tissue stats.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68fabedcc75262434d82bf4b3a74c556
https://doi.org/10.1158/1535-7163.22499559
https://doi.org/10.1158/1535-7163.22499559
PDF file - 529KB, in vitro culture.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d0a60c7986f84d3e3b2fdd62135bf99
https://doi.org/10.1158/1535-7163.22499589
https://doi.org/10.1158/1535-7163.22499589