Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Paul Phojanakong"'
Autor:
Elliot Stieglitz, Aaron C Logan, Emilio Ramos, William C Temple, Matthew A Nix, Akul Naik, Adila Izgutdina, Benjamin J Huang, Gianina Wicaksono, Paul Phojanakong, Juan Antonio Camara Serrano, Elizabeth P Young, Fernando Salangsang, Veronica Steri, Simayijiang Xirenayi, Michelle Hermiston, Arun P Wiita
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 11 (2023)
Background Approximately 50% of patients who receive anti-CD19 CAR-T cells relapse, and new immunotherapeutic targets are urgently needed. We recently described CD72 as a promising target in B-cell malignancies and developed nanobody-based CAR-T cell
Externí odkaz:
https://doaj.org/article/2d39e3cf7d6f4d60aeb1265961906c97
Autor:
Bogdan Popescu, Carlos Stahlhut, Theodore C. Tarver, Sydney Wishner, Bianca J. Lee, Cheryl A. C. Peretz, Cuyler Luck, Paul Phojanakong, Juan Antonio Camara Serrano, Henry Hongo, Jose M. Rivera, Simayijiang Xirenayi, John A. Chukinas, Veronica Steri, Sarah K. Tasian, Elliot Stieglitz, Catherine C. Smith
Mutations in receptor tyrosine kinases (RTKs) FLT3 and KIT are frequent and associated with poor outcomes in acute myeloid leukemia (AML). Although FLT3 inhibitors (FLT3i) are clinically effective, remissions are short-lived due to secondary resistan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49ae1ee8377a977fdca83b311ef68dda
https://doi.org/10.1101/2022.12.01.518665
https://doi.org/10.1101/2022.12.01.518665
Autor:
Kamal Mandal, Gianina Wicaksono, Clinton Yu, Jarrett J. Adams, Michael R. Hoopmann, William C. Temple, Bonell Patiño Escobar, Maryna Gorelik, Christian H. Ihling, Matthew A. Nix, Akul Naik, Emilio Ramos, Corynn Kasap, Veronica Steri, Juan Antonio Camara Serrano, Fernando Salangsang, Paul Phojanakong, Melanie McMillan, Victor Gavallos, Andrew D. Leavitt, Andrea Sinz, Benjamin J. Huang, Elliot Stieglitz, Catherine C. Smith, Robert L. Moritz, Sachdeva S. Sidhu, Lan Huang, Arun P. Wiita
Safely expanding indications for cellular therapies has been challenging given a lack of highly cancer-specific surface markers. Here, we explore the hypothesis that tumor cells express cancer-specific surface protein conformations, invisible to stan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ae2b772f0663a4c42355cf2c0c07b9b
https://doi.org/10.1101/2022.10.10.511511
https://doi.org/10.1101/2022.10.10.511511
Autor:
William C Temple, Gianina Wicaksono, Akul Naik, Adila Izgutdina, Matthew A Nix, Elizabeth Young, Paul Phojanakong, Juan Antonio Camara Serrano, Veronica Steri, Fernando Salangsang, Arun P Wiita
Publikováno v:
Blood. 140:7394-7395
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09ec579e376fbba52982ce0aa579b433
https://doi.org/10.1182/blood-2022-168490
https://doi.org/10.1182/blood-2022-168490
Autor:
Kamal Mandal, Gianina Wicaksono, Clinton Yu, Jarrett J Adams, Michael R Hoopmann, William C Temple, Bonell Patino Escobar, Maryna Gorelik, Christian Ihling, Matthew A Nix, Akul Naik, Emilio Ramos, Corynn Kasap, Veronica Steri, Juan Antonio Camara Serrano, Fernando Salangsang, Paul Phojanakong, Melanie McMillan, Victor Gavallos, Andrew D Leavitt, Andrea Sinz, Benjamin J. Huang, Elliot Stieglitz, Catherine Smith, Robert L Moritz, Sachdeva S Sidhu, Lan Huang, Arun P Wiita
Publikováno v:
Blood. 140:867-868
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::783892af7fbf24f854a1e3f8eb707775
https://doi.org/10.1182/blood-2022-162697
https://doi.org/10.1182/blood-2022-162697
Autor:
Paul Phojanakong, Chin Fen Teo, Alexis M. Thornton, Byron Hann, Nina Shah, Christine Lam, Thomas G. Martin, Jeffrey L. Wolf, Ian Ferguson, Sandy W. Wong, Angela N. Brooks, Prabhakar Bastola, Makeba Marcoulis, Yu-Hsiu T. Lin, Margarette C. Mariano, Arun P. Wiita, Priya Choudhry, Hector H. Huang, Julia Malato
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature communications, vol 11, iss 1
Nature Communications
Nature communications, vol 11, iss 1
Nature Communications
Enhancing the efficacy of proteasome inhibitors (PI) is a central goal in myeloma therapy. We proposed that signaling-level responses after PI may reveal new mechanisms of action that can be therapeutically exploited. Unbiased phosphoproteomics after
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab08cb20defbdefde847c8836b261932
http://link.springer.com/article/10.1038/s41467-020-15521-4
http://link.springer.com/article/10.1038/s41467-020-15521-4
Autor:
Byron Hann, Olivia Gugliemini, Letitia Sarah, Poornima Ramkumar, Martin Kampmann, Yu-Hsiu T. Lin, Veronica Steri, Donghui Wang, Arun P. Wiita, Priya Choudhry, Huimin Geng, Vishesh Sarin, Paul Phojanakong, Neha Paranjape, Makeba Marcoulis
Background: CD38 is a surface ectoenzyme expressed at high levels on myeloma plasma cells and is the target for the monoclonal antibodies (mAbs) daratumumab and isatuximab. These antibodies have multiple mechanisms of action, primarily involving recr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97a6d97ac42c082f13ff8c100f02a76a
https://doi.org/10.1101/2021.08.04.455165
https://doi.org/10.1101/2021.08.04.455165
Autor:
Ian D. Ferguson, Yu-Hsiu T. Lin, Christine Lam, Hao Shao, Kevin M. Tharp, Martina Hale, Corynn Kasap, Margarette C. Mariano, Audrey Kishishita, Bonell Patiño Escobar, Kamal Mandal, Veronica Steri, Donghui Wang, Paul Phojanakong, Sami T. Tuomivaara, Byron Hann, Christoph Driessen, Brian Van Ness, Jason E. Gestwicki, Arun P. Wiita
Publikováno v:
Cell chemical biology. 29(8)
Proteasome inhibitor (PI) resistance remains a central challenge in multiple myeloma. To identify pathways mediating resistance, we first mapped proteasome-associated genetic co-dependencies. We identified heat shock protein 70 (HSP70) chaperones as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e59e3958ef7071082cfd611118aec457
https://pubmed.ncbi.nlm.nih.gov/35853457
https://pubmed.ncbi.nlm.nih.gov/35853457
Autor:
William Temple, Paul Phojanakong, Byron Hann, Veronica Steri, Matthew A. Nix, William J. Karlon, Donghui Wang, Arun P. Wiita
Publikováno v:
Blood. 138:1717-1717
Background: Approximately 50% of pediatric B-ALL patients treated with clinically approved CD19-targeting CAR-T cells do not remain in remission one year after therapy. CD22-targeting CAR-T cells appear to be curative in only a small fraction of CD19
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e79f83403cd905addd68751c963a2285
https://doi.org/10.1182/blood-2021-153935
https://doi.org/10.1182/blood-2021-153935
Autor:
Elliot Stieglitz, Cheryl A.C. Peretz, Jose M. Rivera, Sydney Wishner, Veronica Steri, Theodore C. Tarver, Carlos Stahlhut, Eric Wong, Catherine C. Smith, Timothy T. Ferng, Paul Phojanakong, Bogdan Popescu
Publikováno v:
Blood. 138:2231-2231
Mutations in receptor tyrosine kinases (RTK) FLT3 and KIT occur frequently in Acute Myeloid Leukemia (AML) and are associated with high risk of relapse. FLT3 tyrosine kinase inhibitors (TKI) are clinically approved in AML, but resistance is common an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82e056123ba07b6586ca2dcbe91d89c2
https://doi.org/10.1182/blood-2021-145964
https://doi.org/10.1182/blood-2021-145964