Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Paul Peter, Tak"'
Autor:
Marilin S. Koch, Mykola Zdioruk, Michal O. Nowicki, Alec M. Griffith, Estuardo Aguilar-Cordova, Laura K. Aguilar, Brian W. Guzik, Francesca Barone, Paul Peter Tak, Katharina Schregel, Michael S. Hoetker, James A. Lederer, E. Antonio Chiocca, Ghazaleh Tabatabai, Sean E. Lawler
Publikováno v:
Molecular Therapy: Oncolytics, Vol 26, Iss , Pp 275-288 (2022)
CAN-2409 is a replication-deficient adenovirus encoding herpes simplex virus (HSV) thymidine kinase (tk) currently in clinical trials for treatment of glioblastoma. The expression of tk in transduced cancer cells results in conversion of the pro-drug
Externí odkaz:
https://doaj.org/article/d1ff12c2b9db4d9895906f9830d6592e
Autor:
Xavier Mariette, Francesca Barone, Chiara Baldini, Hendrika Bootsma, Kenneth L. Clark, Salvatore De Vita, David H. Gardner, Robert B. Henderson, Michael Herdman, Karoline Lerang, Prafull Mistry, Raj Punwaney, Raphaele Seror, John Stone, Paul L.A. van Daele, André van Maurik, Nicolas Wisniacki, David A. Roth, Paul Peter Tak
Publikováno v:
JCI Insight, Vol 7, Iss 23 (2022)
BACKGROUND Primary Sjögren’s syndrome (pSS) is characterized by B cell hyperactivity and elevated B-lymphocyte stimulator (BLyS). Anti-BLyS treatment (e.g., belimumab) increases peripheral memory B cells; decreases naive, activated, and plasma B c
Externí odkaz:
https://doaj.org/article/ae87bdd4bc564a1dae2056fee6339f06
Autor:
Kathleen Weisel, Scott Berger, Katie Thorn, Peter C. Taylor, Charles Peterfy, Hilary Siddall, Debra Tompson, Susanne Wang, Emilia Quattrocchi, Susan W. Burriss, Jochen Walter, Paul Peter Tak
Publikováno v:
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-12 (2021)
Abstract Background Receptor-interacting protein kinase 1 (RIPK1) is a key mediator of inflammation through cell death and proinflammatory cytokine production. This multicenter, randomized, double-blind (sponsor-unblinded), placebo-controlled, experi
Externí odkaz:
https://doaj.org/article/3315ea0dbc054e6abb7df36ef9b3b2ae
Autor:
Nicola Scott, Kurt Brown, Paul Peter Tak, Kathy Weisel, Scott Berger, Susanne Wang, Marcy Powell, Matthijs Broer, Clarissa Watts, Debra J Tompson, Susan W Burriss, Simon Hawkins, Kathy Abbott-Banner
Publikováno v:
BMJ Open Gastroenterology, Vol 8, Iss 1 (2021)
Objective Tumour necrosis factor signalling via the receptor-interacting protein kinase 1 (RIPK1) pathway regulates colonic inflammation suggesting that RIPK1 inhibition may be a potential therapeutic target in ulcerative colitis (UC). This phase IIa
Externí odkaz:
https://doaj.org/article/ef7195d8d61f4612b4663afe82235e72
Autor:
Maria Ines Ramos, Samuel Garcia, Boy Helder, Saida Aarrass, Kris. A. Reedquist, Sten E. Jacobsen, Paul Peter Tak, Maria Cristina Lebre
Publikováno v:
Journal of Translational Autoimmunity, Vol 3, Iss , Pp 100066- (2020)
Rheumatoid arthritis (RA) is chronic autoimmune disease which etiology remains unknown. Several cell types have been described to potentiate/aggravate the arthritic process however the initiating event in synovial inflammation is still elusive. Dendr
Externí odkaz:
https://doaj.org/article/6cc4c355f63a4d7d982ae53a47f51eb9
Autor:
Tanja Alexandra Stamm, Klaus Peter Machold, Daniel Aletaha, Farideh Alasti, Peter Lipsky, David Pisetsky, Robert Landewe, Desiree van der Heijde, Alexandre Sepriano, Martin Aringer, Dimitri Boumpas, Gerd Burmester, Maurizio Cutolo, Wolfgang Ebner, Winfried Graninger, Tom Huizinga, Georg Schett, Hendrik Schulze-Koops, Paul-Peter Tak, Emilio Martin-Mola, Ferdinand Breedveld, Josef Smolen
Publikováno v:
Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-12 (2018)
Abstract Background In the present study, we explored the effects of immediate induction therapy with the anti-tumour necrosis factor (TNF)α antibody infliximab (IFX) plus methotrexate (MTX) compared with MTX alone and with placebo (PL) in patients
Externí odkaz:
https://doaj.org/article/a97b96f97a67460cafa27cb6eed114d4
Autor:
Ajesh B. Maharaj, Pragalathan Naidoo, Terisha Ghazi, Naeem S. Abdul, Shanel Dhani, Taskeen F. Docrat, Prithiksha Ramkaran, Paul-Peter Tak, Niek de Vries, Anil A. Chuturgoon
Publikováno v:
BMC Medical Genetics, Vol 19, Iss 1, Pp 1-7 (2018)
Abstract Background Psoriasis and psoriatic arthritis (PsA) are inflammatory associated autoimmune disorders. MicroRNA (miR)-146a plays a crucial role in regulating inflammation. A single nucleotide polymorphism in the miR-146a gene (rs2910164), aber
Externí odkaz:
https://doaj.org/article/84c80fc299f746f0837ab6f6ab0af179
Autor:
David Withers, Anne Diers, Zhi Li, Suaad Idris, Claire Willis, Paul Peter Tak, Francesca Barone
Publikováno v:
Regular and Young Investigator Award Abstracts.
Autor:
Karen I Maijer, Natasja Stæhr Gudmann, Morten Asser Karsdal, Daniëlle M Gerlag, Paul Peter Tak, Anne Christine Bay-Jensen
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0149329 (2016)
OBJECTIVE:Tissue destruction in rheumatoid arthritis (RA) is predominantly mediated by matrix metalloproteinases (MMPs), thereby generating protein fragments. Previous studies have revealed that these fragments include MMP-mediated collagen type I, I
Externí odkaz:
https://doaj.org/article/4de4f0b20fc14ae39e0b3e377e9078cc
Autor:
E Antonio Chiocca, Hiroshi Nakashima, Xiaokui Mo, Isaac Solomon, Alexander Ling, Jared Woods, Joshua Bernstock, Genaro Villa, Raziye Piranlioglu, Ana Montalvo Landivar, Nafisa Masud, Daniel Triggs, James Grant, Patrick Y Wen, Eudocia Lee, Lakshmi Nayak, Ugonma Chukwueke, Tracy Batchelor, David Krisky, Estuardo Aguilar-Cordova, Laura K Aguilar, Soledad Fernandez, Christopher Matheny, Andrea Manzanera, Francesca Barone, Paul Peter Tak, Keith Ligon, David A Reardon
Publikováno v:
Neuro-Oncology. 24:vii61-vii61
BACKGROUND CAN-3110 (rQNestin34.5v2) is an HSV-1 oncolytic viral immunotherapy with one copy of the inflammatory ICP34.5 gene under transcriptional control of the Nestin glioma-specific promoter. We completed a phase 1 sequential dose-escalation tria