Reversible and formaldehyde-mediated covalent binding of a bis-amino mitoxantrone analogue to DNA

Autor: Shyam K. Konda, Jelena Medan, J. Grant Collins, Paul P. Pumuye, Brad E. Sleebs, Suzanne M. Cutts, Celine Kelso, Don R. Phillips

Publikováno v: Organic & Biomolecular Chemistry. 14:4728-4738

The ability of a bis-amino mitoxantrone anticancer drug (named WEHI-150) to form covalent adducts with DNA, after activation by formaldehyde, has been studied by electrospray ionisation mass spectrometry and HPLC. Mass spectrometry results showed tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5bbbd7675d9bb8b11e5c6e8da5f8e96
https://doi.org/10.1039/c6ob00561f

M2, a novel anthracenedione, elicits a potent DNA damage response that can be subverted through checkpoint kinase inhibition to generate mitotic catastrophe

Autor: Don R. Phillips, Brad E. Sleebs, Rebecca A. Bilardi, Suzanne M. Cutts, Keith G. Watson, Mile Pastuovic, Paul P. Pumuye, Benny J. Evison, Robert A. Forrest

Publikováno v: Biochemical pharmacology. 82(11)

Pixantrone is a promising anti-cancer aza-anthracenedione that has prompted the development of new anthracenediones incorporating symmetrical side-chains of increasing length varying from two to five methylene units in each pair of drug side-chains.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::269a92c2fd1dbc26c015e88f7f9921dd
https://pubmed.ncbi.nlm.nih.gov/21889927

Large variability in plasma efavirenz concentration in Papua New Guinea HIV/AIDS patients associated with high frequency of CYP2B6 516T allele.

Autor: Bordin Andriguetti N; Discipline of Pharmacology, Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia., Van Schalkwyk HK; Discipline of Pharmacology, Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia., Barratt DT; Discipline of Physiology, Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia., Tucci J; Department of Pharmacy & Biomedical Sciences, La Trobe University Bendigo Campus, Bendigo, Victoria, Australia., Pumuye P; School of Medicine and Health Sciences, University of Papua New Guinea, National Capital District, Papua New Guinea., Somogyi AA; Discipline of Pharmacology, Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia.

Publikováno v: Clinical and translational science [Clin Transl Sci] 2021 Nov; Vol. 14 (6), pp. 2521-2531. Date of Electronic Publication: 2021 Aug 20.