Výsledky vyhledávání - "Paul P. Hung"

Akademický článek

A microfluidic system for dynamic yeast cell imaging

Autor: Philip J. Lee, Noah C. Helman, Wendell A. Lim, Paul J. Hung

Publikováno v: BioTechniques, Vol 44, Iss 1, Pp 91-95 (2008)

The investigation of cellular processes and gene regulatory networks within living cells requires the development of improved technology for dynamic, single cell imaging. Here, we demonstrate a microfluidic system capable of mechanical trapping of ye

Externí odkaz: https://doaj.org/article/c7637a6f65d74f83b623346401d830e9

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Long-term protection of chimpanzees against high-dose HIV-1 challenge induced by immunization

Publikováno v: Nature Medicine. 3:651-658

A combination AIDS vaccine approach consisting of priming with adenovirus-HIV-1MN gp160 recombinants followed by boosting with HIV-1SF2 gp120 was evaluated in chimpanzees. Long-lasting protection, requiring only three immunizations, was achieved agai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10775f6b9d04dd0a56fd61322128d0d7
https://doi.org/10.1038/nm0697-651

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Isolation and characterization of a highly attenuated respiratory syncytial virus (RSV) vaccine candidate by mutagenesis of the incompletely attenuated RSV A2 ts-1 NG-1 mutant virus

Autor: Robert M. Chanock, Kuo-Hom Lee Hsu, James E. Crowe, Brian R. Murphy, Michael D. Lubeck, Alan R. Davis, Paul P. Hung

Publikováno v: Vaccine. 13:509-515

Ts-1, a temperature sensitive (ts) mutant of RSV, was previously derived from RSV A2 virus by mutagenesis with 5-fluorouracil (5-FU). Ts-1 was attenuated for adult volunteers and seropositive children but retained a low level of virulence in seronega

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6e25df078e34fc290d7de80f069c047
https://doi.org/10.1016/0264-410x(94)00002-5

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Immunogenicity of Recombinant Adenovirus-Human Immunodeficiency Virus Vaccines in Chimpanzees Following Intranasal Administration

Autor: Mark S. Wade, Bheem M. Bhat, Surendra K. Dheer, Pranab K. Chanda, Ramesh A. Bhat, Michael D. Lubeck, Shaw-Guang Lee, Shridhara Murthy, Jorg W. Eichberg, Paul P. Hung, Krishna K. Murthy, Murty Chengalvala, Alan R. Davis, Robert J. Natuk, Satoshi Mizutani

Publikováno v: AIDS Research and Human Retroviruses. 10:1443-1449

Recombinant adenovirus (Ad)-human immunodeficiency virus (HIV) vaccines expressing HIVIIIB Env and Gag proteins were evaluated for immunogenicity in chimpanzees following intranasal administration. When Ad7-, Ad4-, and Ad5-vectored vaccines were admi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97cd8a5261ded643b0c722593dd32d69
https://doi.org/10.1089/aid.1994.10.1443

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Relevance of the guinea-pig necrotic inflammation footpad reaction to safety concerns with MDP-based adjuvants

Autor: Geraldine M. Bonde, Mark H. Levner, Richard N. Hjorth, Paul P. Hung, Elizabeth D. Piner, Kenneth M. Goldberg

Publikováno v: Vaccine. 12:687-690

The guinea-pig necrotic inflammatory reaction described by Nagao and Tanaka was investigated to determine its possible relevance to tuberculin-positive individuals who may receive M D P-based adjuvants. The reaction was induced by a preparatory footp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c518cab16715f59f2670239dfab8637
https://doi.org/10.1016/0264-410x(94)90217-8

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Construction and characterization of adenovirus co-expressing hepatitis B virus surface antigen and interleukin-6

Autor: Kenneth M. Goldberg, S.G. Lee, Jorg W. Eichberg, Sheau-Mei Cheng, Theresa Lindley, Paul P. Hung, Marlene Ronchetti-Blume, Karen P. Virk

Publikováno v: Gene. 138:165-170

Coexpression of biologically active interleukin 6 (IL-6), an immunoregulator, and hepatitis B virus surface antigen (HBsAg), an immunogen, was obtained using an adenovirus type 7 (Ad7) vector. Two recombinant adenoviruses (re-Ad) containing both the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::495a246c335a7597253ceb1564903fe4
https://doi.org/10.1016/0378-1119(94)90801-x

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Immunogenicity of Recombinant Human Adenovirus-Human Immunodeficiency Virus Vaccines in Chimpanzees

Autor: Steven K. Vernon, James M. Wilhelm, Mark S. Wade, Pranab K. Chanda, R J Natuk, Shaw-Guang Lee, Shridhara Murthy, Jorg W. Eichberg, Michael D. Lubeck, Krishna K. Murthy, Satoshi Mizutani, Paul P. Hung, Alan R. Davis, Surendra K. Dheer, Murty Chengalvala

Publikováno v: AIDS Research and Human Retroviruses. 9:395-404

Recombinant human adenovirus (Ad) type 4-, 5-, and 7-vectored vaccines expressing either the HIV env or gag-protease genes were tested for immunogenicity in three chimpanzees. The first phase of the vaccination protocol consisted of a primary and two

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43ad4b2d6e261f3deb62e077c7fe37a9
https://doi.org/10.1089/aid.1993.9.395

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Cotton rats previously immunized with a chimeric RSV FG glycoprotein develop enhanced pulmonary pathology when infected with RSV, a phenomenon not encountered following immunization with vaccinia—RSV recombinants or RSV

Autor: Alex V. Sotnikov, Peter L. Collins, Mark Connors, Alan Waitze, Brian R. Murphy, Paul P. Hung, Cai-Yen Firestone, Robert M. Chanock, Alan R. Davis

Publikováno v: Vaccine. 10:475-484

In studies conducted in the 1960s, children previously immunized with a formalin-inactivated respiratory syncytial virus (RSV) vaccine (FI-RSV) developed a greater incidence and severity of pulmonary disease during subsequent natural RSV infection th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bf99c81298bd043aacccd5cf92919f9
https://doi.org/10.1016/0264-410x(92)90397-3

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Effects of purine nucleoside analogues with a cyclobutane ring and erythromycin A oxime derivatives on duck hepatitis B virus replication in vivo and in cell culture and HIV-1 in cell culture

Autor: William S. Robinson, Patricia L. Marion, Amy E. Brumbaugh, Gulshan Bhatia, Paul P. Hung, Li-Fang Hung, Daniel W. Norbeck, Jacob J. Plattner

Publikováno v: Journal of Medical Virology. 35:180-186

The effects on duck hepatitis B virus (DHBV) replication of specific analogues of two classes of chemical compounds not previously tested against hepadnaviruses are described. One is erythromycin A-9-methyloxime (EMO) and other oxime derivatives of e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3b65697b5fd4a30200862bd64f0954d
https://doi.org/10.1002/jmv.1890350307

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Adenovirus vectors for gene expression

Autor: Robert J. Natuk, Satoshi Mizutani, Bruce B. Mason, Paul P. Hung, Michael D. Lubeck, Alan R. Davis, Bernard J. Selling, Murty Chengalvala, Ramesh A. Bhat, Pranab K. Chanda, Bheem M. Bhat, Kuo-Hom Lee Hsu

Publikováno v: Current Opinion in Biotechnology. 2:718-722

Adenoviruses possess a combination of features that make them highly suitable as vectors for expression of heterologous genes. Non-conditional and non-defective adeno-vectors have been constructed to obtain high level expression of a number of foreig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9ab48086476045e150baa099a779a87
https://doi.org/10.1016/0958-1669(91)90041-3

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