Výsledky vyhledávání - "Paul P. Bernard"

Akademický článek

Efficient Two-Step Synthesis of Novel Pyrimido[4,5-d] Pyrimidines with Potent Neuroprotective, Antioxidant, and Aβ Anti-Aggregation Properties

Autor: Ghada Ben Ameur, Emna Maalej, Helene Martin, Anne-Sophie Jacquinot, Nadine Barbanneau, Paul J. Bernard, José Marco-Contelles, Fakher Chabchoub, Lhassane Ismaili

Publikováno v: Chemistry, Vol 6, Iss 4, Pp 695-705 (2024)

Eleven new differently substituted N,7-diphenylpyrimido [4,5-d]pyrimidin-4-amines 4a–k were synthesized from readily available reagents in a simple and inexpensive two-step procedure with yields up to 57%. Neuroprotective analysis against H2O2 and

Externí odkaz: https://doaj.org/article/9019af1564a9476d973ff43077d4706c

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Akademický článek

Design and Synthesis of Multi-Functional Ligands through Hantzsch Reaction: Targeting Ca2+ Channels, Activating Nrf2 and Possessing Cathepsin S Inhibitory, and Antioxidant Properties

Autor: Irene Pachón-Angona, Paul J. Bernard, Alexey Simakov, Maciej Maj, Krzysztof Jozwiak, Anna Novotna, Carina Lemke, Michael Gütschow, Helene Martin, María-Jesús Oset-Gasque, José-Marco Contelles, Lhassane Ismaili

Publikováno v: Pharmaceutics, Vol 16, Iss 1, p 121 (2024)

This work relates to the design and synthesis of a series of novel multi-target directed ligands (MTDLs), i.e., compounds 4a–l, via a convenient one-pot three-component Hantzsch reaction. This approach targeted calcium channel antagonism, antioxida

Externí odkaz: https://doaj.org/article/91b84aaa929141c3b798a1c55836bddf

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Akademický článek

Biginelli Reaction Synthesis of Novel Multitarget-Directed Ligands with Ca2+ Channel Blocking Ability, Cholinesterase Inhibition, Antioxidant Capacity, and Nrf2 Activation

Autor: Rim Malek, Alexey Simakov, Audrey Davis, Maciej Maj, Paul J. Bernard, Artur Wnorowski, Helene Martin, José Marco-Contelles, Fakher Chabchoub, Patrick Dallemagne, Christophe Rochais, Krzysztof Jozwiak, Lhassane Ismaili

Publikováno v: Molecules, Vol 28, Iss 1, p 71 (2022)

Novel multitarget-directed ligands BIGI 4a-d and BIGI 5a-d were designed and synthesized with a simple and cost-efficient procedure via a one-pot three-component Biginelli reaction targeting acetyl-/butyrylcholinesterases inhibition, calcium channel

Externí odkaz: https://doaj.org/article/c1008cfa0311472f9605360beca986c5

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Akademický článek

Benzochromenopyrimidines: Synthesis, Antiproliferative Activity against Colorectal Cancer and Physicochemical Properties

Autor: Emna Choura, Fares Elghali, Paul J. Bernard, Dhouha Msalbi, José Marco-Contelles, Sami Aifa, Lhassane Ismaili, Fakher Chabchoub

Publikováno v: Molecules, Vol 27, Iss 22, p 7878 (2022)

Ten new differently substituted 3-benzyl-5-aryl-3,5-dihydro-4H-benzo[6,7]chromeno[2,3-d]pyrimidin-4,6,11-triones 3 were synthesized by a simple and cost-efficient procedure in a one-pot, three-component reaction from readily available ethyl 2-amino-4

Externí odkaz: https://doaj.org/article/680d832206084032814164729d9f5c95

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Akademický článek

Enhanced long term potentiation and decreased AMPA receptor desensitization in the acute period following a single kainate induced early life seizure

Autor: Heather O'Leary, Paul B. Bernard, Anna M. Castano, Tim A. Benke

Publikováno v: Neurobiology of Disease, Vol 87, Iss , Pp 134-144 (2016)

Neonatal seizures are associated with long term disabilities including epilepsy and cognitive deficits. Using a neonatal seizure rat model that does not develop epilepsy, but develops a phenotype consistent with other models of intellectual disabilit

Externí odkaz: https://doaj.org/article/3b6f12906b4640fe88ac995b4717a720

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Akademický článek

Phosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures

Autor: Paul B. Bernard, Anna M. Castano, Heather O'Leary, Kameron Simpson, Michael D. Browning, Tim A. Benke

Publikováno v: Neurobiology of Disease, Vol 59, Iss , Pp 1-17 (2013)

Outside of Fragile X syndrome (FXS), the role of Fragile-X Mental Retardation Protein (FMRP) in mediating neuropsychological abnormalities is not clear. FMRP, p70-S6 kinase (S6K) and protein phosphatase 2A (PP2A) are thought to cooperate as a dynamic

Externí odkaz: https://doaj.org/article/4a059921a781407b98ebd9b84e3fe38e

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Elektronická kniha

Joseph II and Bavaria : Two Eighteenth Century Attempts at German Unification

Autor: Paul P. Bernard

they represented a congeries of varied languages, cultures and traditions. Moreover the status of Germany, in theory ruled by the Hapsburgs in their capacity of Holy Roman Emperors, had since the conclusion of the Thirty Years War been in some doubt.

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