Zobrazeno 1 - 10
of 276
pro vyhledávání: '"Paul P Van Veldhoven"'
Autor:
Srikanth Karnati, Gani Oruqaj, Harshavardhan Janga, Srinu Tumpara, Claudia Colasante, Paul P Van Veldhoven, Nancy Braverman, Adrian Pilatz, Thomas J Mariani, Eveline Baumgart-Vogt
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0203466 (2018)
Despite the important functions of PPARγ in various cell types of the lung, PPARγ-deficiency in club cells induces only mild emphysema. Peroxisomes are distributed in a similar way as PPARγ in the lung and are mainly enriched in club and AECII cel
Externí odkaz:
https://doaj.org/article/8b4fd6fea18d41279e2508bb98c1b19b
Autor:
Srikanth Karnati, Vannuruswamy Garikapati, Gerhard Liebisch, Paul P Van Veldhoven, Bernhard Spengler, Gerd Schmitz, Eveline Baumgart-Vogt
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0203464 (2018)
Lipids play very important roles in lung biology, mainly reducing the alveolar surface tension at the air-liquid interface thereby preventing end-expiratory collapse of the alveoli. In the present study we performed an extensive quantitative lipidomi
Externí odkaz:
https://doaj.org/article/ce11df4ed2d44e9fbd33285604bc560b
Autor:
Ana I Arroyo, Paola G Camoletto, Laura Morando, Marco Sassoe‐Pognetto, Maurizio Giustetto, Paul P Van Veldhoven, Edward H Schuchman, Maria D Ledesma
Publikováno v:
EMBO Molecular Medicine, Vol 6, Iss 3, Pp 398-413 (2014)
Abstract Understanding the role of lipids in synapses and the aberrant molecular mechanisms causing the cognitive deficits that characterize most lipidosis is necessary to develop therapies for these diseases. Here we describe sphingomyelin (SM) as a
Externí odkaz:
https://doaj.org/article/d9cfd6c1aba447d89b9dc036289ee51f
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 3 (2015)
Reduction-oxidation or ‘redox’ reactions are an integral part of a broad range of cellular processes such as gene expression, energy metabolism, protein import and folding, and autophagy. As many of these processes are intimately linked with cell
Externí odkaz:
https://doaj.org/article/41b3702149804b67a180dd1843020413
Autor:
Valérie Van der Eecken, André Clippe, Sophie Dekoninck, Julie Goemaere, Geoffroy Walbrecq, Paul P Van Veldhoven, Bernard Knoops
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e72844 (2013)
In human, the subcellular targeting of peroxiredoxin-5 (PRDX5), a thioredoxin peroxidase, is dependent on the use of multiple alternative transcription start sites and two alternative in-frame translation initiation sites, which determine whether or
Externí odkaz:
https://doaj.org/article/9f52ae0204ed4aeda6bfb531b3e1eccb
Autor:
Martine Bot, Paul P Van Veldhoven, Saskia C A de Jager, Jason Johnson, Niels Nijstad, Peter J Van Santbrink, Marijke M Westra, Gerd Van Der Hoeven, Marion J Gijbels, Carsten Müller-Tidow, Georg Varga, Uwe J F Tietge, Johan Kuiper, Theo J C Van Berkel, Jerzy-Roch Nofer, Ilze Bot, Erik A L Biessen
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63360 (2013)
Altered sphingosine 1-phosphate (S1P) homeostasis and signaling is implicated in various inflammatory diseases including atherosclerosis. As S1P levels are tightly controlled by S1P lyase, we investigated the impact of hematopoietic S1P lyase (Sgpl1(
Externí odkaz:
https://doaj.org/article/1a0d95655b81411ea2e0c24d8f384462
Autor:
Yingmei Feng, Sarah Schouteden, Rachel Geenens, Vik Van Duppen, Paul Herijgers, Paul Holvoet, Paul P Van Veldhoven, Catherine M Verfaillie
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e47286 (2012)
RationaleHematopoietic stem/progenitor cells (HSPC) are responsible for maintaining the blood system as a result of their self-renewal and multilineage differentiation capacity. Recently, studies have suggested that HDL cholesterol may inhibit and im
Externí odkaz:
https://doaj.org/article/b2fcfb1efc154ad09a2d8cf1865d6154
Autor:
Karine H Hellemans, Jean-Claude Hannaert, Bart Denys, Knut R Steffensen, Cindy Raemdonck, Geert A Martens, Paul P Van Veldhoven, Jan-Ake Gustafsson, Daniel Pipeleers
Publikováno v:
PLoS ONE, Vol 4, Iss 9, p e7266 (2009)
Chronically elevated levels of fatty acids-FA can cause beta cell death in vitro. Beta cells vary in their individual susceptibility to FA-toxicity. Rat beta cells were previously shown to better resist FA-toxicity in conditions that increased trigly
Externí odkaz:
https://doaj.org/article/139ce2ea13384226bea0bc3ef4a7c07d
Autor:
Paola G Camoletto, Hugo Vara, Laura Morando, Emma Connell, Fabio P Marletto, Maurizio Giustetto, Marco Sassoè-Pognetto, Paul P Van Veldhoven, Maria Dolores Ledesma
Publikováno v:
PLoS ONE, Vol 4, Iss 4, p e5310 (2009)
Consensus exists that lipids must play key functions in synaptic activity but precise mechanistic information is limited. Acid sphingomyelinase knockout mice (ASMko) are a suitable model to address the role of sphingolipids in synaptic regulation as
Externí odkaz:
https://doaj.org/article/ea6987fcec6c419ea64acb42c9c2419a
Autor:
Ritesh Kumar Baboota, Abhijit Babaji Shinde, Katleen Lemaire, Marc Fransen, Stefan Vinckier, Paul P. Van Veldhoven, Frans Schuit, Myriam Baes
Publikováno v:
Molecular Metabolism, Vol 22, Iss , Pp 71-83 (2019)
Objectives: Peroxisomes play a crucial role in lipid and reactive oxygen species metabolism, but their importance for pancreatic β-cell functioning is presently unknown. To examine the contribution of peroxisomal metabolism to β-cell homeostasis in
Externí odkaz:
https://doaj.org/article/a082d50af4494d76b5ad1f303193c154