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Akademický článek

Identification of novel small molecule inhibitors for solute carrier SGLT1 using proteochemometric modeling

Autor: Lindsey Burggraaff, Paul Oranje, Robin Gouka, Pieter van der Pijl, Marian Geldof, Herman W. T. van Vlijmen, Adriaan P. IJzerman, Gerard J. P. van Westen

Publikováno v: Journal of Cheminformatics, Vol 11, Iss 1, Pp 1-10 (2019)

Abstract Sodium-dependent glucose co-transporter 1 (SGLT1) is a solute carrier responsible for active glucose absorption. SGLT1 is present in both the renal tubules and small intestine. In contrast, the closely related sodium-dependent glucose co-tra

Externí odkaz: https://doaj.org/article/b9669e4d11ac4a33aff529bb88597da9

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Identification of novel small molecule inhibitors for solute carrier SGLT1 using proteochemometric modeling

Autor: Adriaan P. IJzerman, Lindsey Burggraaff, Gerard J. P. van Westen, Robin Gouka, Marian Geldof, Herman van Vlijmen, Paul Oranje, Pieter C. van der Pijl

Publikováno v: Journal of Cheminformatics
Journal of Cheminformatics, Vol 11, Iss 1, Pp 1-10 (2019)
Journal of Cheminformatics, 11, 15

Sodium-dependent glucose co-transporter 1 (SGLT1) is a solute carrier responsible for active glucose absorption. SGLT1 is present in both the renal tubules and small intestine. In contrast, the closely related sodium-dependent glucose co-transporter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef3aa084caa7eebc708b4023e5c4e8e2
https://doi.org/10.1186/s13321-019-0337-8

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Development of an Affordable, Sustainable and Efficacious Plant-Based Immunomodulatory Food Ingredient Based on Bell Pepper or Carrot RG-I Pectic Polysaccharides

Autor: Jari Helin, Ruud Albers, Gordana Bothe, Ellen Kreijveld, Ute Pohl, Paul Oranje, Annick Mercenier, Henk A. Schols, Jean Hypolites Koek, Marcela Aparicio-Vergara, Pieter Van den Abbeele, Sue McKay, Tzoumaki Maria

Publikováno v: Nutrients, 13(3), 1-22
Nutrients, Vol 13, Iss 963, p 963 (2021)
Nutrients 13 (2021) 3
Nutrients
Volume 13
Issue 3

The prevalence of acute respiratory infections and their impact on quality of life underlies the need for efficacious solutions that are safe, sustainable and economically viable. Polysaccharides in several (traditional) plant extracts have been show

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ddebf60b34974aba9eee4778435fd2d
https://doi.org/10.3390/nu13030963

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Oxylipin profiling in endothelial cells in vitro – Effects of DHA and hydrocortisone upon an inflammatory challenge

Autor: A.C. Motta, Rob J. Vreeken, Doris M. Jacobs, Paul Oranje, Katrin Strassburg

Publikováno v: Prostaglandins & Other Lipid Mediators. 144:106352

Omega-3 poly-unsaturated fatty acids have been shown to have beneficial effects on several inflammatory-driven endpoints such as cardiovascular diseases. The anti-inflammatory effects of docosahexaenoic acid (DHA) are largely mediated through various

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ade9136ae3ff36f244a1721ea74f6d61
https://doi.org/10.1016/j.prostaglandins.2019.106352

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