Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Paul O. Hassa"'
Autor:
Natalie Möckli, Anna Deplazes, Paul O. Hassa, Zhaolei Zhang, Matthias Peter, Michael O. Hottiger, Igor Stagljar, Daniel Auerbach
Publikováno v:
BioTechniques, Vol 42, Iss 6, Pp 725-730 (2007)
Interactions between proteins are central to most biological processes; consequently, understanding the latter requires identification of all possible protein interactions within a cell. To extend the range of existing assays for the detection of pro
Externí odkaz:
https://doaj.org/article/5a75c6a465d241ce83f6f178ab6a7ab5
Autor:
Michael O. Hottiger, Max Gassmann, Stephan Keller, Taras Valovka, Simon Messner, Suheda Erener, Paul O. Hassa, Lubor Borsig, Michael Elser
Hypoxia-inducible factor 1 (HIF-1) is the key transcription factor regulating hypoxia-dependent gene expression. Lack of oxygen stabilizes HIF-1, which in turn modulates the gene expression pattern to adapt cells to the hypoxic environment. Activatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ec2b7ad7081efb235317ab87839a86c
https://doi.org/10.1158/1541-7786.c.6542742
https://doi.org/10.1158/1541-7786.c.6542742
Autor:
Michael O. Hottiger, Max Gassmann, Stephan Keller, Taras Valovka, Simon Messner, Suheda Erener, Paul O. Hassa, Lubor Borsig, Michael Elser
Supplementary Figure S1 from Poly(ADP-Ribose) Polymerase 1 Promotes Tumor Cell Survival by Coactivating Hypoxia-Inducible Factor-1–Dependent Gene Expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04d5dbcc2f624ebfa4073369a29c0672
https://doi.org/10.1158/1541-7786.22520718
https://doi.org/10.1158/1541-7786.22520718
Autor:
Michael O. Hottiger, François Mach, Barbara E. Stähli, Christian M. Matter, Monika Gersbach, Christine Lohmann, Vincent Braunersreuther, Felix C. Tanner, Thomas F. Lüscher, Jan Borén, Giovanni G. Camici, Paul O. Hassa, Tobias von Lukowicz, Bernhard Odermatt
Publikováno v:
Cardiovascular Research, Vol. 78, No 1 (2008) pp. 158-66
AIMS: Atherosclerosis is the leading cause of death in Western societies and a chronic inflammatory disease. However, the key mediators linking recruitment of inflammatory cells to atherogenesis remain poorly defined. Poly(ADP-ribose) polymerase 1 (P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2287753e12011f9dbe9d333930ba633
http://doc.rero.ch/record/291728/files/cvm110.pdf
http://doc.rero.ch/record/291728/files/cvm110.pdf
Autor:
Bernhard Lüscher, Amedeo Caflisch, Ralph Imhof, Florian Rosenthal, Hans Christian Winkler, Karla L. H. Feijs, Emilie Frugier, Alexandra H. Forst, Mario Bonalli, Michael O. Hottiger, Paul O. Hassa, David Fischer
Publikováno v:
Nature structural & molecular biology
ADP-ribosylation is an important post-translational protein modification (PTM) that regulates diverse biological processes. ADP-ribosyltransferase diphtheria toxin-like 10 (ARTD10, also known as PARP10) mono-ADP-ribosylates acidic side chains and is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeeffc9dc4d6ad605012f5eb0eb88fe9
Publikováno v:
Molecular Cancer
Diffuse large B-cell lymphoma (DLBCL) is a clinically heterogeneous lymphoid malignancy and the most common subtype of non-Hodgkin’s lymphoma in adults, with one of the highest mortality rates in most developed areas of the world. More than half of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4ae0260a4a5f354a7185ee981e92939
https://doi.org/10.1186/s12943-015-0474-2
https://doi.org/10.1186/s12943-015-0474-2
Publikováno v:
Trends in biochemical sciences
ADP-ribosylation is a post-translational modification of proteins catalyzed by ADP-ribosyltransferases. It comprises the transfer of the ADP-ribose moiety from NAD+ to specific amino acid residues on substrate proteins or to ADP-ribose itself. Curren
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efcd084fc4820fc46e653115fa64aab1
https://doi.org/10.1016/j.tibs.2009.12.003
https://doi.org/10.1016/j.tibs.2009.12.003
Publikováno v:
Nucleic Acids Research
Poly(ADP-ribose) polymerase 1 (PARP1) synthesizes poly(ADP-ribose) (PAR) using nicotinamide adenine dinucleotide (NAD) as a substrate. Despite intensive research on the cellular functions of PARP1, the molecular mechanism of PAR formation has not bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c04924904466d23e98d0fd6088602a4
https://doi.org/10.1093/nar/gkp229
https://doi.org/10.1093/nar/gkp229
Autor:
Henning Kleine, Paul O. Hassa, Elzbieta Poreba, Krzysztof Lesniewicz, Michael O. Hottiger, Bernhard Lüscher, David W. Litchfield, Brian H. Shilton
Publikováno v:
Molecular Cell. 32:57-69
ADP-ribosylation controls many processes, including transcription, DNA repair, and bacterial toxicity. ADP-ribosyltransferases and poly-ADP-ribose polymerases (PARPs) catalyze mono- and poly-ADP-ribosylation, respectively, and depend on a highly cons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a7f6b2ecc30edaa058e67fc45769ccc
https://doi.org/10.1016/j.molcel.2008.08.009
https://doi.org/10.1016/j.molcel.2008.08.009
Publikováno v:
Journal of Molecular Biology. 377:668-678
Nuclear factor kappa B (NF-kappaB) plays an important role in the transcriptional regulation of genes involved in inflammation and cell survival. Transcriptional coactivators that methylate histones become increasingly important. Recently, we provide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17f686909ee203cf2f40412a395921e9
https://doi.org/10.1016/j.jmb.2008.01.044
https://doi.org/10.1016/j.jmb.2008.01.044