Candida albicans exhibit two classes of cell surface binding sites for serum albumin defined by their affinity, abundance and prospective role in interkingdom signalling.

Autor: Claire Teevan-Hanman, Paul O'Shea

Publikováno v: PLoS ONE, Vol 16, Iss 7, p e0254593 (2021)

Serum albumin binding to the yeast form of Candida albicans is described. Two populations of binding site are identified using two complementary spectroscopic techniques: an extrinsic fluorescent probe, 3-hexa-decanoyl-7-hydrocoumarin ([HEXCO) added

Externí odkaz: https://doaj.org/article/9e82fbcdd1ee4fe2a25f7081ac4a28fc

α-Tocopherols modify the membrane dipole potential leading to modulation of ligand binding by P-glycoprotein

Autor: Sterenn Davis, Benjamin M. Davis, Joanna L. Richens, Kelly-Ann Vere, Peter G. Petrov, C. Peter Winlove, Paul O'Shea

Publikováno v: Journal of Lipid Research, Vol 56, Iss 8, Pp 1543-1550 (2015)

α-Tocopherol (vitamin E) has attracted considerable attention as a potential protective or palliative agent. In vitro, its free radical-scavenging antioxidant action has been widely demonstrated. In vivo, however, vitamin E treatment exhibits neglig

Externí odkaz: https://doaj.org/article/aac750488e9b4b118f23d0cf2fec7eb0

Receptor-independent interaction of bacterial lipopolysaccharide with lipid and lymphocyte membranes; the role of cholesterol.

Autor: Filip Ciesielski, Benjamin Davis, Michael Rittig, Boyan B Bonev, Paul O'Shea

Publikováno v: PLoS ONE, Vol 7, Iss 6, p e38677 (2012)

Lipopolysaccharide (LPS) is a major constituent of bacterial outer membranes where it makes up the bulk of the outer leaflet and plays a key role as determinant of bacterial interactions with the host. Membrane-free LPS is known to activate T-lymphoc

Externí odkaz: https://doaj.org/article/8f993cdedb514d1d95998bcdecc7ebb8

Infectious Aortitis Due to Salmonella Species Masquerading as Lung Malignancy

Autor: John-Paul O’Shea, MD, PhD, Darakhshan Ahmad, MD, Dorothy Garner, MD, Tasaduq N. Fazili, MD

Publikováno v: JACC: Case Reports, Vol 20, Iss , Pp 101943- (2023)

Infectious aortitis is a rare but devastating vascular infection with mortality exceeding 40%. Early diagnosis is crucial but often hampered by radiographic mimickers. We report a patient who was thought to have lung cancer but ultimately found to ha

Externí odkaz: https://doaj.org/article/0baf13ed59aa437783b0b3d290150cee

The interaction of styrene maleic acid copolymers with phospholipids in Langmuir monolayers, vesicles and nanodiscs; a structural study

Autor: Stephen C.L. Hall, Cecilia Tognoloni, Richard A. Campbell, Joanna Richens, Paul O'Shea, Ann E. Terry, Gareth J. Price, Tim R. Dafforn, Karen J. Edler, Thomas Arnold

Publikováno v: Hall, S C L, Tognoloni, C, Campbell, R A, Richens, J, O'shea, P, Terry, A E, Price, G J, Dafforn, T R, Edler, K J & Arnold, T 2022, ' The Interaction of Styrene Maleic Acid Copolymers with Phospholipids in Langmuir Monolayers, Vesicles and Nanodiscs; a Structural Study ', Journal of Colloid and Interface Science, vol. 625, pp. 220-236 . https://doi.org/10.1016/j.jcis.2022.03.102

HypothesisSelf-assembly of amphipathic styrene maleic acid copolymers with phospholipids in aqueous solution results in the formation of ‘nanodiscs’ containing a planar segment of phospholipid bilayer encapsulated by a polymer belt. Recently, stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3ad979891fffa5f05c6e52f90165dea
https://doi.org/10.1016/j.jcis.2022.03.102