Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Paul Ning-Man Cheng"'
Autor:
Abdelrahman Y. Fouda, Zhimin Xu, Jutamas Suwanpradid, Modesto Rojas, Esraa Shosha, Tahira Lemtalsi, Chintan Patel, Ji Xing, Syed A. Zaidi, Wenbo Zhi, Brain K. Stansfield, Paul Ning-Man Cheng, S. Priya Narayanan, R. William Caldwell, Ruth B. Caldwell
Publikováno v:
Cell Death and Disease, Vol 13, Iss 8, Pp 1-12 (2022)
Abstract Current therapies for treatment of proliferative retinopathy focus on retinal neovascularization (RNV) during advanced disease and can trigger adverse side-effects. Here, we have tested a new strategy for limiting neurovascular injury and pr
Externí odkaz:
https://doaj.org/article/9425c35153c5408eae0768802d3f931a
Autor:
Sze-Kwan Lam, Yuan-Yuan Li, Shi Xu, Leanne Lee Leung, Kin-Pong U, Yan-Fang Zheng, Paul Ning-Man Cheng, James Chung-Man Ho
Publikováno v:
Respiratory Research, Vol 18, Iss 1, Pp 1-11 (2017)
Abstract Background Malignant pleural mesothelioma (MPM) is a difficult-to-treat global disease. Pegylated arginase (BCT-100) has recently shown anti-tumor effects in hepatocellular carcinoma, acute myeloid leukemia and melanoma. This study aims to i
Externí odkaz:
https://doaj.org/article/a97a7d74581f4178979f3ddf0ed621b4
Autor:
Ammar A. Abdelrahman, Wael Eldahshan, R. William Caldwell, Zhimin Xu, Paul Ning-Man Cheng, Syed Ah. Zaidi, Abdelrahman Y. Fouda, Tahira Lemtalsi, Esraa Shosha, Ruth B. Caldwell, S. Priya Narayanan
Publikováno v:
Exp Neurol
Arginase 1 (A1) is the enzyme that hydrolyzes the amino acid, L-arginine, to ornithine and urea. We have previously shown that A1 deletion worsens retinal ischemic injury, suggesting a protective role of A1. In this translational study, we aimed to s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56559a73ba7f7b60382a7ee3564fff6d
https://europepmc.org/articles/PMC9122100/
https://europepmc.org/articles/PMC9122100/
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports
Scientific Reports
Drug resistance is a major hurdle in the treatment of small cell lung cancer (SCLC). Previously we demonstrated the potential anticancer effect of pegylated arginase BCT-100 in SCLC cell lines and xenograft models. To facilitate future clinical appli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3d5fd4d716b21231c7a3317e40da915
http://link.springer.com/article/10.1038/s41598-019-48476-8
http://link.springer.com/article/10.1038/s41598-019-48476-8
Publikováno v:
Oncogenesis, Vol 8, Iss 3, Pp 1-11 (2019)
Oncogenesis
Oncogenesis
Depletion of arginine induced by PEGylated arginase 1 (ARG1) (BCT-100) has shown anticancer effects in arginine auxotrophic cancers that lack argininosuccinate synthetase (ASS1) and ornithine transcarbamylase (OTC). High levels of endogenous arginase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bbe0f0744179eaa6a4c663e6797af1b
http://link.springer.com/article/10.1038/s41389-019-0128-0
http://link.springer.com/article/10.1038/s41389-019-0128-0
Autor:
Shi Xu, James Chung-Man Ho, Dengchuan Wang, Wei Li, Paul Ning-Man Cheng, Zhuyun Zhao, Yue-Ming Liu, Peng Zhang, Changneng Ke
Publikováno v:
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity, Vol 2021 (2021)
Oxidative Medicine and Cellular Longevity, Vol 2021 (2021)
Background Bladder cancer is one of the dominant cancers worldwide, especially for male. Currently, the therapeutical regimen of bladder cancer is based on surgery, radiation therapy, chemotherapy and immunotherapy, but the clinical outcome is still
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a57c6626555ce08d2d0dbec334239be4
Publikováno v:
Cancer Science
Small cell lung cancer (SCLC) accounts for approximately 13% of all lung cancer cases. Small cell lung cancer is characterized by frequent relapse, and current treatments lack tumor specificity. Arginine is a non‐essential amino acid for human norm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b51f9def02af322c407d2c0da2a2179b
https://doi.org/10.1111/cas.13782
https://doi.org/10.1111/cas.13782
Publikováno v:
Oncology Reports
Arginine depletion has shown anticancer effects among arginine auxotrophic cancers. An anti-proliferative effect of pegylated arginase (BCT-100) has been shown in acute myeloid leukaemia, hepatocellular carcinoma and mesothelioma. The aim of the pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::329f89f91ed1d1050a7d33480efe4f12
https://pubmed.ncbi.nlm.nih.gov/30066894
https://pubmed.ncbi.nlm.nih.gov/30066894
Publikováno v:
Journal of Thoracic Oncology. 13:S972-S973
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f32859d6ea52000d2729617ce2739e6
https://doi.org/10.1016/j.jtho.2018.08.1831
https://doi.org/10.1016/j.jtho.2018.08.1831
Autor:
Yuan-Yuan Li, Shi Xu, James Chung-Man Ho, Yanfang Zheng, Sze-Kwan Lam, Kin-Pong U, Leanne Lee Leung, Paul Ning-Man Cheng
Publikováno v:
Respiratory Research
Respiratory Research, Vol 18, Iss 1, Pp 1-11 (2017)
Respiratory Research, Vol 18, Iss 1, Pp 1-11 (2017)
BACKGROUND: Malignant pleural mesothelioma (MPM) is a difficult-to-treat global disease. Pegylated arginase (BCT-100) has recently shown anti-tumor effects in hepatocellular carcinoma, acute myeloid leukemia and melanoma. This study aims to investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a5f328f84b7bc65a8a975520e9efc1c
https://pubmed.ncbi.nlm.nih.gov/28464918
https://pubmed.ncbi.nlm.nih.gov/28464918