Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Paul Nawroth"'
Publikováno v:
Monitor Versorgungsforschung, Vol 2024, Iss 05, Pp 52-56 (2024)
Die Autoren einer Arbeit, die den möglichen Effekt verschiedener Steuermodelle bzw. eine gestaffelte Herstellerabgabe auf gezuckerte Getränke hochrechnete, kamen zu dem Schluss, dass solch eine Steuer in den Jahren 2023 bis 2043 einige Effekte in D
Externí odkaz:
https://doaj.org/article/19e6ed8074db43ca854d4cfbd4ba139e
Autor:
Xin Qian, Stephan Klatt, Katrin Bennewitz, David Philipp Wohlfart, Bowen Lou, Ye Meng, Michael Buettner, Gernot Poschet, Jakob Morgenstern, Thomas Fleming, Carsten Sticht, Ingrid Hausser, Ingrid Fleming, Julia Szendroedi, Peter Paul Nawroth, Jens Kroll
Publikováno v:
Advanced Science, Vol 11, Iss 4, Pp n/a-n/a (2024)
Abstract Omega‐6 fatty acids are the primary polyunsaturated fatty acids in most Western diets, while their role in diabetes remains controversial. Exposure of omega‐6 fatty acids to an oxidative environment results in the generation of a highly
Externí odkaz:
https://doaj.org/article/d3e9abcfffc843caa8b54bf9e9a82f24
Autor:
Christoph Tobias Tabler, Elisabeth Lodd, Katrin Bennewitz, Chiara Simone Middel, Vanessa Erben, Hannes Ott, Tanja Poth, Thomas Fleming, Jakob Morgenstern, Ingrid Hausser, Carsten Sticht, Gernot Poschet, Julia Szendroedi, Peter Paul Nawroth, Jens Kroll
Publikováno v:
Redox Biology, Vol 59, Iss , Pp 102576- (2023)
Glyoxalase 2 is the second enzyme of the glyoxalase system, catalyzing the detoxification of methylglyoxal to d-lactate via SD-Lactoylglutathione. Recent in vitro studies have suggested Glo2 as a regulator of glycolysis, but if Glo2 regulates glucose
Externí odkaz:
https://doaj.org/article/8ec9121e06394c43ad839a73926f3863
Autor:
David Philipp Wohlfart, Bowen Lou, Chiara Simone Middel, Jakob Morgenstern, Thomas Fleming, Carsten Sticht, Ingrid Hausser, Rüdiger Hell, Hans-Peter Hammes, Julia Szendrödi, Peter Paul Nawroth, Jens Kroll
Publikováno v:
Redox Biology, Vol 50, Iss , Pp 102249- (2022)
Reactive carbonyl species (RCS) are spontaneously formed in the metabolism and modify and impair the function of DNA, proteins and lipids leading to several organ complications. In zebrafish, knockout of the RCS detoxifying enzymes glyoxalase 1 (Glo
Externí odkaz:
https://doaj.org/article/3d1cdcad30e44060993f91c00777083e
Autor:
Fabiola Garcia Cortizo, Daniel Pfaff, Angela Wirth, Andrea Schlotterer, Rebekka Medert, Jakob Morgenstern, Tobias Weber, Hans-Peter Hammes, Thomas Fleming, Peter Paul Nawroth, Marc Freichel, Aurelio A. Teleman
Publikováno v:
Molecular Metabolism, Vol 55, Iss , Pp 101406- (2022)
Objective: Methylglyoxal (MG) is a highly reactive α-oxoaldehyde that glycates proteins. MG has been linked to the development of diabetic complications: MG is the major precursor of advanced glycation end products (AGEs), a risk marker for diabetic
Externí odkaz:
https://doaj.org/article/6586086fec034e6e93d18634639a1dce
Autor:
Haozhe Qi, Felix Schmöhl, Xiaogang Li, Xin Qian, Christoph T. Tabler, Katrin Bennewitz, Carsten Sticht, Jakob Morgenstern, Thomas Fleming, Nadine Volk, Ingrid Hausser, Elena Heidenreich, Rüdiger Hell, Peter Paul Nawroth, Jens Kroll
Publikováno v:
Advanced Science, Vol 8, Iss 18, Pp n/a-n/a (2021)
Abstract Increased acrolein (ACR), a toxic metabolite derived from energy consumption, is associated with diabetes and its complications. However, the molecular mechanisms are mostly unknown, and a suitable animal model with internal increased ACR do
Externí odkaz:
https://doaj.org/article/5965a1df7cfd4a61ae1372f68cdba8f5
Autor:
Dagmar Schumacher, Jakob Morgenstern, Yoko Oguchi, Nadine Volk, Stefan Kopf, Jan Benedikt Groener, Peter Paul Nawroth, Thomas Fleming, Marc Freichel
Publikováno v:
Molecular Metabolism, Vol 18, Iss , Pp 143-152 (2018)
Objectives: The deficit of Glyoxalase I (Glo1) and the subsequent increase in methylglyoxal (MG) has been reported to be one the five mechanisms by which hyperglycemia causes diabetic late complications. Aldo-keto reductases (AKR) have been shown to
Externí odkaz:
https://doaj.org/article/ab909cb76d024a0a9c7acda54454efcc
Autor:
Xiaogang Li, Felix Schmöhl, Haozhe Qi, Katrin Bennewitz, Christoph T. Tabler, Gernot Poschet, Rüdiger Hell, Nadine Volk, Tanja Poth, Ingrid Hausser, Jakob Morgenstern, Thomas Fleming, Peter Paul Nawroth, Jens Kroll
Publikováno v:
iScience, Vol 23, Iss 12, Pp 101763- (2020)
Summary: Regulation of glucose homeostasis is a fundamental process to maintain blood glucose at a physiological level, and its dysregulation is associated with the development of several metabolic diseases. Here, we report on a zebrafish mutant for
Externí odkaz:
https://doaj.org/article/8038c2712d2741548133c7a0daabb4b8
Autor:
Bowen Lou, Mike Boger, Katrin Bennewitz, Carsten Sticht, Stefan Kopf, Jakob Morgenstern, Thomas Fleming, Rüdiger Hell, Zuyi Yuan, Peter Paul Nawroth, Jens Kroll
Publikováno v:
Redox Biology, Vol 37, Iss , Pp 101723- (2020)
Increased methylglyoxal (MG) formation is associated with diabetes and its complications. In zebrafish, knockout of the main MG detoxifying system Glyoxalase 1, led to limited MG elevation but significantly elevated aldehyde dehydrogenases (ALDH) act
Externí odkaz:
https://doaj.org/article/72bf44548f7d4df986b82bce975c982f
Autor:
Johanna Zemva, Christoph Andreas Fink, Thomas Henry Fleming, Leonard Schmidt, Anne Loft, Stephan Herzig, Robert André Knieß, Matthias Mayer, Bernd Bukau, Peter Paul Nawroth, Jens Tyedmers
Publikováno v:
Redox Biology, Vol 13, Iss C, Pp 674-686 (2017)
Energy production is inevitably linked to the generation of toxic metabolites, such as reactive oxygen and carbonyl species, known as major contributors to ageing and degenerative diseases. It remains unclear how cells can adapt to elevated energy fl
Externí odkaz:
https://doaj.org/article/8aeca16a48664371be95eb4093fd15d0