Zobrazeno 1 - 10
of 242
pro vyhledávání: '"Paul N. Reynolds"'
Autor:
Juliette Delhove, Moayed Alawami, Matthew Macowan, Susan E. Lester, Phan T. Nguyen, Hubertus P. A. Jersmann, Paul N. Reynolds, Eugene Roscioli
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Differentiated air–liquid interface models are the current standard to assess the mucociliary phenotype using clinically-derived samples in a controlled environment. However, obtaining basal progenitor airway epithelial cells (AEC) from th
Externí odkaz:
https://doaj.org/article/8de3028fcb26457fbfee98a05cc022aa
Autor:
Greg Hodge, Hubertus Jersmann, Mark Holmes, Patrick Asare, Eugene Roscioli, Paul N. Reynolds, Sandra Hodge
Publikováno v:
Biology, Vol 12, Iss 9, p 1261 (2023)
Introduction: Pro-inflammatory CD8+ T cells are increased in the lungs and also in the peripheral circulation of both smokers and chronic obstructive pulmonary disease (COPD) patients. The reason for this is unclear but has been described as a spillo
Externí odkaz:
https://doaj.org/article/a2f00e34891a48c98c0515b1233566ce
Autor:
Helen E. Jo, Tamera J. Corte, Ian Glaspole, Christopher Grainge, Peter M. A. Hopkins, Yuben Moodley, Paul N. Reynolds, Sally Chapman, E. Haydn Walters, Christopher Zappala, Heather Allan, Gregory J. Keir, Wendy A. Cooper, Annabelle M. Mahar, Samantha Ellis, Sacha Macansh, Nicole S. Goh
Publikováno v:
BMC Pulmonary Medicine, Vol 19, Iss 1, Pp 1-7 (2019)
Abstract Background and objective Gastroesophageal reflux disease (GORD) is highly prevalent in idiopathic pulmonary fibrosis (IPF) and may play a role in its pathogenesis. Recent IPF treatment guidelines suggest that all patients with IPF be conside
Externí odkaz:
https://doaj.org/article/e7a23ace75d242ce910465bad83b3312
Autor:
Eugene Roscioli, Rhys Hamon, Susan E. Lester, Hubertus P. A. Jersmann, Paul N. Reynolds, Sandra Hodge
Publikováno v:
Respiratory Research, Vol 19, Iss 1, Pp 1-13 (2018)
Abstract Background Individuals with respiratory disease are being increasingly exposed to wildfire smoke as populations encroach further into forested regions and climate change continues to bring higher temperatures with lower rainfall. Frequent ex
Externí odkaz:
https://doaj.org/article/0d5376415c6f40d2b6462a59dc73c7f9
Publikováno v:
Therapeutic Advances in Respiratory Disease, Vol 14 (2020)
Background: The class III NAD-dependent histone deacetylase (HDAC) sirtuin 1 (SIRT1) is an important regulator of senescence, aging, and inflammation. SIRT1de-acetylates chromatin histones, thereby silencing inflammatory gene transcription. We have r
Externí odkaz:
https://doaj.org/article/f929d0fc1de84ab796fc790cd960fd5a
Autor:
Peter G. Gibson, Ian A. Yang, John W. Upham, Paul N. Reynolds, Sandra Hodge, Alan L. James, Christine Jenkins, Matthew J. Peters, Guy B. Marks, Melissa Baraket, Heather Powell, Jodie L. Simpson
Publikováno v:
ERJ Open Research, Vol 5, Iss 4 (2019)
Background Low-dose azithromycin is an effective therapy for persistent asthma; however, its benefit in severe asthma is not defined. Methods Participants with severe asthma were identified from the AMAZES randomised, placebo-controlled trial of long
Externí odkaz:
https://doaj.org/article/cf5d487e0add488f850f74735d2b3382
Autor:
Stephen M. Humphries, John A. Mackintosh, Helen E. Jo, Simon L. F. Walsh, Mario Silva, Lucio Calandriello, Sally Chapman, Samantha Ellis, Ian Glaspole, Nicole Goh, Christopher Grainge, Peter M. A. Hopkins, Gregory J. Keir, Yuben Moodley, Paul N. Reynolds, E. Haydn Walters, David Baraghoshi, Athol U. Wells, David A. Lynch, Tamera J. Corte
Publikováno v:
Respirology. 27:1045-1053
Prediction of disease course in patients with progressive pulmonary fibrosis remains challenging. The purpose of this study was to assess the prognostic value of lung fibrosis extent quantified at computed tomography (CT) using data-driven texture an
Autor:
Greg Hodge, Hubertus Jersmann, Hai B Tran, Patrick F Asare, Minnu Jayapal, Paul N Reynolds, Mark Holmes, Sandra Hodge
Publikováno v:
Clin Exp Immunol
We previously showed increased steroid-resistant CD28null CD8+ senescent lymphocyte subsets in the peripheral blood from patients with chronic obstructive pulmonary disease (COPD). These cells expressed decreased levels of the glucocorticoid receptor
Autor:
Simon L. F. Walsh, John A. Mackintosh, Lucio Calandriello, Mario Silva, Nicola Sverzellati, Anna Rita Larici, Stephen M. Humphries, David A. Lynch, Helen E. Jo, Ian Glaspole, Christopher Grainge, Nicole Goh, Peter M. A. Hopkins, Yuben Moodley, Paul N. Reynolds, Christopher Zappala, Gregory Keir, Wendy A. Cooper, Annabelle M. Mahar, Samantha Ellis, Athol U. Wells, Tamera J. Corte
Publikováno v:
American journal of respiratory and critical care medicine. 206(7)
Autor:
Rhys Hamon, A. Moshensky, Sandra Hodge, John Shin, Leigh Thredgold, Christine M. Bojanowski, L E Crotty Alexander, Hubertus Jersmann, Phan Nguyen, Miranda P. Ween, K Herewane, Nicole A Bastian, Paul N. Reynolds, Arash Badiei
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
The growing interest in regulating flavored E-liquids must incorporate understanding of the “flavoring profile” of each E-liquid—which flavorings (flavoring chemicals) are present and at what concentrations not just focusing on the flavor on th