Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Paul N. Patrone"'
Autor:
Lili Wang, Paul N. Patrone, Anthony J. Kearsley, Jerilyn R. Izac, Adolfas K. Gaigalas, John C. Prostko, Hyung Joon Kwon, Weichun Tang, Martina Kosikova, Hang Xie, Linhua Tian, Elzafir B. Elsheikh, Edward J. Kwee, Troy Kemp, Simon Jochum, Natalie Thornburg, L. Clifford McDonald, Adi V. Gundlapalli, Sheng Lin-Gibson
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 21, p 15705 (2023)
COVID-19 has highlighted challenges in the measurement quality and comparability of serological binding and neutralization assays. Due to many different assay formats and reagents, these measurements are known to be highly variable with large uncerta
Externí odkaz:
https://doaj.org/article/964a2ccf770f43cdb30f18f0fd8a3ed6
Autor:
Linhua Tian, Elzafir B. Elsheikh, Paul N. Patrone, Anthony J. Kearsley, Adolfas K. Gaigalas, Sarah Inwood, Sheng Lin-Gibson, Dominic Esposito, Lili Wang
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 5, p 2723 (2021)
Quantitative and robust serology assays are critical measurements underpinning global COVID-19 response to diagnostic, surveillance, and vaccine development. Here, we report a proof-of-concept approach for the development of quantitative, multiplexed
Externí odkaz:
https://doaj.org/article/87efdc6765a145fd986f0f8dc643c8c0
Publikováno v:
Lab on a Chip. 22:3217-3228
Flow cytometry is an invaluable technology in biomedical research, but confidence in single-cell measurements remains limited due to a lack of appropriate techniques for uncertainty quantification (UQ). It is particularly challenging to evaluate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21ecabc7f957528778798fec58506039
https://doi.org/10.1039/d1lc01169c
https://doi.org/10.1039/d1lc01169c
Autor:
Rayanne A, Luke, Anthony J, Kearsley, Nora, Pisanic, Yukari C, Manabe, David L, Thomas, Christopher D, Heaney, Paul N, Patrone
Publikováno v:
ArXiv.
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has emphasized the importance and challenges of correctly interpreting antibody test results. Identification of positive and negative samples requires a classification strategy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::20f696dd3ad28a110e61a9c8aeaf15c4
https://pubmed.ncbi.nlm.nih.gov/35795812
https://pubmed.ncbi.nlm.nih.gov/35795812
Publikováno v:
Analytical and Bioanalytical Chemistry
Motivated by the current COVID-19 health crisis, we consider data analysis for quantitative polymerase chain-reaction (qPCR) measurements. We derive a theoretical result specifying the conditions under which all qPCR amplification curves (including t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::937004e73a81f2323eb150c7e4c63b07
https://doi.org/10.1007/s00216-020-02930-z
https://doi.org/10.1007/s00216-020-02930-z
Autor:
Samuel P. Forry, Paul N. Patrone, J. Alexander Liddle, Daniel Schiffels, Jacob M. Majikes, Anthony J. Kearsley, Michael Zwolak
Publikováno v:
Nucleic Acids Res
Structural DNA nanotechnology, as exemplified by DNA origami, has enabled the design and construction of molecularly-precise objects for a myriad of applications. However, limitations in imaging, and other characterization approaches, make a quantita
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88674080835d94a797fb569bffee74bc
https://doi.org/10.1093/nar/gkaa283
https://doi.org/10.1093/nar/gkaa283
Autor:
Paul N. Patrone, Prajakta Bedekar, Nora Pisanic, Yukari C. Manabe, David L. Thomas, Christopher D. Heaney, Anthony J. Kearsley
Publikováno v:
ArXiv
article-version (number) 1
article-version (status) pre
article-version (number) 1
article-version (status) pre
In diagnostic testing, establishing an indeterminate class is an effective way to identify samples that cannot be accurately classified. However, such approaches also make testing less efficient and must be balanced against overall assay performance.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d1aec5042d592441f59d1ab420ee0aa
https://pubmed.ncbi.nlm.nih.gov/35714754
https://pubmed.ncbi.nlm.nih.gov/35714754
An accurate multiclass classification strategy is crucial to interpreting antibody tests. However, traditional methods based on confidence intervals or receiver operating characteristics lack clear extensions to settings with more than two classes. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7790e0354a9e8da6ffe53c0a5bf604f7
Serology testing can identify past infection by quantifying the immune response of an infected individual providing important public health guidance. Individual immune responses are time-dependent, which is reflected in antibody measurements. Moreove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eb7e511feb6cf01d4cacf1bdf658cbd
Autor:
Rayanne A. Luke, Anthony J. Kearsley, Nora Pisanic, Yukari C. Manabe, David L. Thomas, Christopher D. Heaney, Paul N. Patrone
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has emphasized the importance and challenges of correctly interpreting antibody test results. Identification of positive and negative samples requires a classification strategy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81be3da971472a43acb6831ebfa2dbfa