A supernumerary synthetic chromosome in Komagataella phaffii as a repository for extraneous genetic material

Autor: Dariusz Abramczyk, Maria del Carmen Sanchez Olmos, Adan Andres Ramirez Rojas, Daniel Schindler, Daniel Robertson, Stephen McColm, Adele L. Marston, Paul N. Barlow

Publikováno v: Microbial Cell Factories, Vol 22, Iss 1, Pp 1-19 (2023)

Abstract Background Komagataella phaffii (Pichia pastoris) is a methylotrophic commercially important non-conventional species of yeast that grows in a fermentor to exceptionally high densities on simple media and secretes recombinant proteins effici

Externí odkaz: https://doaj.org/article/d96f7342d724424bbcf9697fae49fd08

Complement inhibitor factor H expressed by breast cancer cells differentiates CD14+ human monocytes into immunosuppressive macrophages

Autor: Karolina I. Smolag, Christine M. Mueni, Karin Leandersson, Karin Jirström, Catharina Hagerling, Matthias Mörgelin, Paul N. Barlow, Myriam Martin, Anna M. Blom

Publikováno v: OncoImmunology, Vol 9, Iss 1 (2020)

Macrophages are a major immune cell type in the tumor microenvironment, where they display a tumor-supporting phenotype. Factor H (FH) is a complement inhibitor that also plays a role in several cellular functions. To date, the phenotype of monocytes

Externí odkaz: https://doaj.org/article/6c50c64369fa422c8e0e499d07853f36

Revealing the sequence and resulting cellular morphology of receptor-ligand interactions during Plasmodium falciparum invasion of erythrocytes.

Autor: Greta E Weiss, Paul R Gilson, Tana Taechalertpaisarn, Wai-Hong Tham, Nienke W M de Jong, Katherine L Harvey, Freya J I Fowkes, Paul N Barlow, Julian C Rayner, Gavin J Wright, Alan F Cowman, Brendan S Crabb

Publikováno v: PLoS Pathogens, Vol 11, Iss 2, p e1004670 (2015)

During blood stage Plasmodium falciparum infection, merozoites invade uninfected erythrocytes via a complex, multistep process involving a series of distinct receptor-ligand binding events. Understanding each element in this process increases the pot

Externí odkaz: https://doaj.org/article/1a1fe246a3be48d4bf55ff5da97ff1d3

Dynamic design: manipulation of millisecond timescale motions on the energy landscape of cyclophilin A

Autor: Harris Ioannidis, Alessio De Simone, Arun A. Gupta, Jordi Juárez-Jiménez, Andrew Baldwin, Malcolm D. Walkinshaw, Gogulan Karunanithy, Julien Michel, Antonia S. J. S. Mey, Alison N. Hulme, Charis Georgiou, Paul N. Barlow

Publikováno v: Chemical Science
Juárez-jiménez, J, Gupta, A A, Karunanithy, G, Mey, A S J S, Georgiou, C, Ioannidis, H, De Simone, A, Barlow, P N, Hulme, A N, Walkinshaw, M D, Baldwin, A J & Michel, J 2020, ' Dynamic design : Manipulation of millisecond timescale motions on the energy landscape of cyclophilin A ', Chemical Science, vol. 11, no. 10, pp. 2670-2680 . https://doi.org/10.1039/C9SC04696H
Dipòsit Digital de la UB
Universidad de Barcelona

Proteins need to interconvert between many conformations in order to function, many of which are formed transiently, and sparsely populated. Particularly when the lifetimes of these states approach the millisecond timescale, identifying the relevant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d0ba71167b38389d43b04acead7d98d
http://hdl.handle.net/2445/179325

Structural analysis of the C-terminal region (modules 18-20) of complement regulator factor H (FH).

Autor: Hugh P Morgan, Haydyn D T Mertens, Mara Guariento, Christoph Q Schmidt, Dinesh C Soares, Dmitri I Svergun, Andrew P Herbert, Paul N Barlow, Jonathan P Hannan

Publikováno v: PLoS ONE, Vol 7, Iss 2, p e32187 (2012)

Factor H (FH) is a soluble regulator of the human complement system affording protection to host tissues. It selectively inhibits amplification of C3b, the activation-specific fragment of the abundant complement component C3, in fluid phase and on se

Externí odkaz: https://doaj.org/article/867b87b33f8e47b6b339f77f3225b596