Using matrix assisted laser desorption ionisation mass spectrometry combined with machine learning for vaccine authenticity screening

Autor: Rebecca Clarke, Tehmina Bharucha, Benediktus Yohan Arman, Bevin Gangadharan, Laura Gomez Fernandez, Sara Mosca, Qianqi Lin, Kerlijn Van Assche, Robert Stokes, Susanna Dunachie, Michael Deats, Hamid A. Merchant, Céline Caillet, John Walsby-Tickle, Fay Probert, Pavel Matousek, Paul N. Newton, Nicole Zitzmann, James S. O. McCullagh

Publikováno v: npj Vaccines, Vol 9, Iss 1, Pp 1-14 (2024)

Abstract The global population is increasingly reliant on vaccines to maintain population health with billions of doses used annually in immunisation programmes. Substandard and falsified vaccines are becoming more prevalent, caused by both the degra

Externí odkaz: https://doaj.org/article/f005fcfa3a62421b8cb44d66f94b298d

Predicting mortality in febrile adults: comparative performance of the MEWS, qSOFA, and UVA scores using prospectively collected data among patients in four health-care sites in sub-Saharan Africa and South-Eastern AsiaResearch in context

Autor: Sham Lal, Manophab Luangraj, Suzanne H. Keddie, Elizabeth A. Ashley, Oliver Baerenbold, Quique Bassat, John Bradley, John A. Crump, Nicholas A. Feasey, Edward W. Green, Kevin C. Kain, Ioana D. Olaru, David G. Lalloo, Chrissy h. Roberts, David C.W. Mabey, Christopher C. Moore, Heidi Hopkins, Sara Ajanovic, Benjamin Amos, Stéphanie Baghoumina, Núria Balanza, Tsitsi Bandason, Tapan Bhattacharyya, Stuart D. Blacksell, Zumilda Boca, Christian Bottomley, Justina M. Bramugy, Clare IR. Chandler, Vilada Chansamouth, Mabvuto Chimenya, Joseph Chipanga, Anelsio Cossa, Ethel Dauya, Catherine Davis, Xavier de Lamballerie, Justin Dixon, Somyoth Douangphachanh, Audrey Dubot-Pérès, Michelle M. Durkin, Rashida A. Ferrand, Colin Fink, Elizabeth JA. Fitchett, Alessandro Gerada, Stephen R. Graves, Edward Green, Becca L. Handley, Coll D. Hutchison, Risara Jaksuwan, Jessica Jervis, Jayne Jones, Khamxeng Khounpaseuth, Katharina Kranzer, Khamfong Kunlaya, Pankaj Lal, Yoel Lubell, David CW. Mabey, Eleanor MacPherson, Forget Makoga, Sengchanh Manichan, Tegwen Marlais, Florian Maurer, Mayfong Mayxay, Michael Miles, Polycarp Mogeni, Campos Mucasse, Paul N. Newton, Chelsea Nguyen, Vilayouth Phimolsarnnousith, Mathieu Picardeau, Chrissy H. Roberts, Amphone Sengduangphachanh, Siho Sengsavang, Molly Sibanda, Somvai Singha, John Stenos, Ampai Tanganuchitcharnchai, Hira Tanvir, James E. Ussher, Marta Valente, Marie A. Voice, Manivanh Vongsouvath, Msopole Wamaka, L Joseph Wheat, Shunmay Yeung

Publikováno v: EClinicalMedicine, Vol 77, Iss , Pp 102856- (2024)

Summary: Background: Clinical severity scores can identify patients at risk of severe disease and death, and improve patient management. The modified early warning score (MEWS), the quick Sequential (Sepsis-Related) Organ Failure Assessment (qSOFA),

Externí odkaz: https://doaj.org/article/472ab60c07af4c819f058bc83c88007e

Diagnosis of human leptospirosis: systematic review and meta-analysis of the diagnostic accuracy of the Leptospira microscopic agglutination test, PCR targeting Lfb1, and IgM ELISA to Leptospira fainei serovar Hurstbridge

Autor: Marta Valente, Justina Bramugy, Suzanne H. Keddie, Heidi Hopkins, Quique Bassat, Oliver Baerenbold, John Bradley, Jane Falconer, Ruth H. Keogh, Paul N. Newton, Mathieu Picardeau, John A. Crump

Publikováno v: BMC Infectious Diseases, Vol 24, Iss 1, Pp 1-22 (2024)

Abstract Background Leptospirosis is an underdiagnosed infectious disease with non-specific clinical presentation that requires laboratory confirmation for diagnosis. The serologic reference standard remains the microscopic agglutination test (MAT) o

Externí odkaz: https://doaj.org/article/107385c9be84493ea1c39b9537b2ac1b

The uncertain role of substandard and falsified medicines in the emergence and spread of antimicrobial resistance

Autor: Sean Cavany, Stella Nanyonga, Cathrin Hauk, Cherry Lim, Joel Tarning, Benn Sartorius, Christiane Dolecek, Céline Caillet, Paul N. Newton, Ben S. Cooper

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-9 (2023)

Abstract Approximately 10% of antimicrobials used by humans in low- and middle-income countries are estimated to be substandard or falsified. In addition to their negative impact on morbidity and mortality, they may also be important drivers of antim

Externí odkaz: https://doaj.org/article/860426eaee644f83b3abb09caabe2c8b

Longitudinal comparison of bacterial pathogen seropositivity among wet market vendors in the Lao People's Democratic Republic

Autor: Nilandone Senvanpan, Vilayouth Phimolsarnnousith, Sayaphet Rattanavong, Mayfong Mayxay, Daniel Reinharz, Amanda E. Fine, Paul F. Horwood, Philippe Dussart, Stuart D. Blacksell, Mathieu Pruvot, Paul N. Newton, Matthew T. Robinson

Publikováno v: One Health, Vol 17, Iss , Pp 100618- (2023)

Wild animal trade for human consumption is a global issue, involving complex interactions between economics, culture, food security and conservation. Whilst being a biodiversity issue, it is also a major public health concern, with recent epidemics a

Externí odkaz: https://doaj.org/article/d08b523cafc34d11a03b2c479472b77a