Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Paul N Valdmanis"'
Autor:
Samuel N Smukowski, Cassidy Danyko, Jenna Somberg, Eli J Kaufman, Meredith M Course, Nadia Postupna, Melissa Barker-Haliski, C Dirk Keene, Paul N Valdmanis
Publikováno v:
PLoS Genetics, Vol 20, Iss 7, p e1011359 (2024)
Proper transport of RNAs to synapses is essential for localized translation of proteins in response to synaptic signals and synaptic plasticity. Alzheimer's disease (AD) is a neurodegenerative disease characterized by accumulation of amyloid aggregat
Externí odkaz:
https://doaj.org/article/2df89832c2e746d691e31f7e13071a67
Autor:
Giulia Monti, Mads Kjolby, Anne Mette G. Jensen, Mariet Allen, Juliane Reiche, Peter L. Møller, Raquel Comaposada-Baró, Bartlomiej E. Zolkowski, Cármen Vieira, Margarita Melnikova Jørgensen, Ida E. Holm, Paul N. Valdmanis, Niels Wellner, Christian B. Vægter, Sarah J. Lincoln, Anders Nykjær, Nilüfer Ertekin-Taner, Jessica E. Young, Mette Nyegaard, Olav M. Andersen
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-18 (2021)
Abstract SORL1 is strongly associated with both sporadic and familial forms of Alzheimer’s disease (AD), but a lack of information about alternatively spliced transcripts currently limits our understanding of the role of SORL1 in AD. Here, we descr
Externí odkaz:
https://doaj.org/article/6593f8c6612a4dd48b7424bbb99fda5f
Autor:
Alec S. T. Smith, Changho Chun, Jennifer Hesson, Julie Mathieu, Paul N. Valdmanis, David L. Mack, Byung-Ok Choi, Deok-Ho Kim, Mark Bothwell
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Gene editing technologies hold great potential to enhance our ability to model inheritable neurodegenerative diseases. Specifically, engineering multiple amyotrophic lateral sclerosis (ALS) mutations into isogenic cell populations facilitates determi
Externí odkaz:
https://doaj.org/article/b867e9f17fc7469794bf34151937519a
Autor:
Paul N. Valdmanis, Hak Kyun Kim, Kirk Chu, Feijie Zhang, Jianpeng Xu, Elizabeth M. Munding, Jia Shen, Mark A. Kay
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
miR-122 is a highly expressed microRNA in the liver. Here the authors analyse the mouse liver microRNA landscape following depletion of miR-122 and the impact that this has on its target mRNAs.
Externí odkaz:
https://doaj.org/article/bce2ee1a64f046a383d8e6d4a3be7c1a
Autor:
Hak Kyun Kim, Jianpeng Xu, Kirk Chu, Hyesuk Park, Hagoon Jang, Pan Li, Paul N. Valdmanis, Qiangfeng Cliff Zhang, Mark A. Kay
Publikováno v:
Cell Reports, Vol 29, Iss 12, Pp 3816-3824.e4 (2019)
Summary: tRNA-derived small RNAs (tsRNAs) have been implicated in many cellular processes, yet the detailed mechanisms are not well defined. We previously found that the 3′ end of Leu-CAG tRNA-derived small RNA (LeuCAG3′tsRNA) regulates ribosome
Externí odkaz:
https://doaj.org/article/7fc1d65a3de04db386de4c87ad791584
Autor:
André Lieber, Paul N. Valdmanis, Charles W. Drescher, Iain A. McNeish, Meredith M. Course, Chang Li
Population-wide testing for cancer-associated mutations has established that more than one-fifth of ovarian and breast carcinomas are associated with inherited risk. Salpingo-oophorectomy and/or mastectomy are currently the only effective options off
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::176bc5014777c6138b13fa0fe07f7589
https://doi.org/10.1158/0008-5472.c.6511806.v1
https://doi.org/10.1158/0008-5472.c.6511806.v1
Autor:
André Lieber, Paul N. Valdmanis, Charles W. Drescher, Iain A. McNeish, Meredith M. Course, Chang Li
Supplementary Fig. S1. Rat Neu is expressed in MMC cells. Supplementary Fig. S2. Gating strategy used for immunophenotyping. Supplementary Fig. S3. Immunophenotyping of GFP+ cells in the bone marrow and spleen (MMC model). Supplementary Fig.S4. GFP e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb9a22892668ee8a6d5023216d07d29b
https://doi.org/10.1158/0008-5472.22424535.v1
https://doi.org/10.1158/0008-5472.22424535.v1
Autor:
Sarah Lincoln, Peter L. Møller, Juliane Reiche, Anne Mette G. Jensen, Margarita Melnikova Jørgensen, Bartlomiej E. Zolkowski, Niels Wellner, Mads Kjolby, Anders Nykjaer, Jessica E. Young, Ida E. Holm, Nilufer Ertekin-Taner, Giulia Monti, Mariet Allen, Christian Bjerggaard Vaegter, Olav M. Andersen, Raquel Comaposada-Baró, Paul N. Valdmanis, Cármen Vieira, Mette Nyegaard
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-18 (2021)
Acta Neuropathologica Communications
Monti, G, Kjolby, M, Jensen, A M G, Allen, M, Reiche, J, Møller, P L, Comaposada-Baró, R, Zolkowski, B E, Vieira, C, Jørgensen, M M, Holm, I E, Valdmanis, P N, Wellner, N, Vægter, C B, Lincoln, S J, Nykjær, A, Ertekin-Taner, N, Young, J E, Nyegaard, M & Andersen, O M 2021, ' Expression of an alternatively spliced variant of SORL1 in neuronal dendrites is decreased in patients with Alzheimer's disease ', Acta Neuropathologica Communications, vol. 9, 43 . https://doi.org/10.1186/s40478-021-01140-7
Acta Neuropathologica Communications
Monti, G, Kjolby, M, Jensen, A M G, Allen, M, Reiche, J, Møller, P L, Comaposada-Baró, R, Zolkowski, B E, Vieira, C, Jørgensen, M M, Holm, I E, Valdmanis, P N, Wellner, N, Vægter, C B, Lincoln, S J, Nykjær, A, Ertekin-Taner, N, Young, J E, Nyegaard, M & Andersen, O M 2021, ' Expression of an alternatively spliced variant of SORL1 in neuronal dendrites is decreased in patients with Alzheimer's disease ', Acta Neuropathologica Communications, vol. 9, 43 . https://doi.org/10.1186/s40478-021-01140-7
SORL1 is strongly associated with both sporadic and familial forms of Alzheimer’s disease (AD), but a lack of information about alternatively spliced transcripts currently limits our understanding of the role of SORL1 in AD. Here, we describe a SOR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79ad653f92bf542e720982592384a034
https://doaj.org/article/6593f8c6612a4dd48b7424bbb99fda5f
https://doaj.org/article/6593f8c6612a4dd48b7424bbb99fda5f
Publikováno v:
Molecular Therapy. Nucleic Acids
Gene knockdown using short hairpin RNAs (shRNAs) is a promising strategy for targeting dominant mutations; however, delivering too much shRNA can disrupt the processing of endogenous microRNAs (miRNAs) and lead to toxicity. Here, we sought to underst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec62a66c7124acf7d3b9e21156c1aa49
https://doi.org/10.1016/j.omtn.2019.12.007
https://doi.org/10.1016/j.omtn.2019.12.007
Autor:
Meredith M Course, Kathryn Gudsnuk, C Dirk Keene, Thomas D Bird, Suman Jayadev, Paul N Valdmanis
Publikováno v:
Brain
Alzheimer’s disease is the most common neurodegenerative disease, characterized by dementia and premature death. Early-onset familial Alzheimer’s disease is caused in part by pathogenic variants in presenilin 1 (PSEN1) and presenilin 2 (PSEN2), a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8bba41a0ccd6a8285ab2774df7d652b
https://pubmed.ncbi.nlm.nih.gov/35949106
https://pubmed.ncbi.nlm.nih.gov/35949106