Zobrazeno 1 - 10
of 217
pro vyhledávání: '"Paul N Barlow"'
Autor:
Greta E Weiss, Paul R Gilson, Tana Taechalertpaisarn, Wai-Hong Tham, Nienke W M de Jong, Katherine L Harvey, Freya J I Fowkes, Paul N Barlow, Julian C Rayner, Gavin J Wright, Alan F Cowman, Brendan S Crabb
Publikováno v:
PLoS Pathogens, Vol 11, Iss 2, p e1004670 (2015)
During blood stage Plasmodium falciparum infection, merozoites invade uninfected erythrocytes via a complex, multistep process involving a series of distinct receptor-ligand binding events. Understanding each element in this process increases the pot
Externí odkaz:
https://doaj.org/article/1a1fe246a3be48d4bf55ff5da97ff1d3
Autor:
Dariusz Abramczyk, Maria del Carmen Sanchez Olmos, Adan Andres Ramirez Rojas, Daniel Schindler, Daniel Robertson, Stephen McColm, Adele L. Marston, Paul N. Barlow
Publikováno v:
Microbial Cell Factories, Vol 22, Iss 1, Pp 1-19 (2023)
Abstract Background Komagataella phaffii (Pichia pastoris) is a methylotrophic commercially important non-conventional species of yeast that grows in a fermentor to exceptionally high densities on simple media and secretes recombinant proteins effici
Externí odkaz:
https://doaj.org/article/d96f7342d724424bbcf9697fae49fd08
Autor:
Patience B Tetteh-Quarcoo, Christoph Q Schmidt, Wai-Hong Tham, Richard Hauhart, Haydyn D T Mertens, Arthur Rowe, John P Atkinson, Alan F Cowman, J Alexandra Rowe, Paul N Barlow
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34820 (2012)
Complement receptor-type 1 (CR1, CD35) is the immune-adherence receptor, a complement regulator, and an erythroid receptor for Plasmodium falciparum during merozoite invasion and subsequent rosette formation involving parasitized and non-infected ery
Externí odkaz:
https://doaj.org/article/1bd17d28c12044c59c9376624a417214
Autor:
Hugh P Morgan, Haydyn D T Mertens, Mara Guariento, Christoph Q Schmidt, Dinesh C Soares, Dmitri I Svergun, Andrew P Herbert, Paul N Barlow, Jonathan P Hannan
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e32187 (2012)
Factor H (FH) is a soluble regulator of the human complement system affording protection to host tissues. It selectively inhibits amplification of C3b, the activation-specific fragment of the abundant complement component C3, in fluid phase and on se
Externí odkaz:
https://doaj.org/article/867b87b33f8e47b6b339f77f3225b596
Publikováno v:
PLoS ONE, Vol 4, Iss 7, p e6315 (2009)
BACKGROUND:Despite sharing 92% sequence identity, paralogous human translation elongation factor 1 alpha-1 (eEF1A1) and elongation factor 1 alpha-2 (eEF1A2) have different but overlapping functional profiles. This may reflect the differential require
Externí odkaz:
https://doaj.org/article/acdb1a2291264173a3c3b61522594b06
Autor:
Paul N. Barlow, Salomé Llabrés, Arun A. Gupta, César Mendoza-Martínez, Julien Michel, Michail Papadourakis
Publikováno v:
Mendoza-martinez, C, Papadourakis, M, Llabrés, S, Gupta, A A, Barlow, P N & Michel, J 2022, ' Energetics of a protein disorder–order transition in small molecule recognition ', Chemical Science, vol. 13, no. 18, pp. 5220-5229 . https://doi.org/10.1039/D2SC00028H
Many proteins recognise other proteins via mechanisms that involve the folding of intrinsically disordered regions upon complex formation. Here we investigate how the selectivity of a drug-like small molecule arises from its modulation of a protein d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dede3ba04c85719ea94fab316ab8b52
http://wrap.warwick.ac.uk/166219/1/WRAP-Energetics-protein-disorder-small-molecule-recognition-2022.pdf
http://wrap.warwick.ac.uk/166219/1/WRAP-Energetics-protein-disorder-small-molecule-recognition-2022.pdf
Autor:
Robyn M, Biggs, Elisavet, Makou, Scott, Lauder, Andrew P, Herbert, Paul N, Barlow, Suresh K, Katti
Publikováno v:
Current eye research. 47(7)
GEM103 is a recombinantly produced full-length version of the human complement factor H (CFH) under clinical investigation for treatment of age-related macular degeneration (AMD) in individuals carrying an AMD risk-associated genetic variant ofKey bi
Autor:
John David Parkin, Elisavet Makou, Richard G. Bailey, Georg Hähner, Heather J. Johnston, Paul N. Barlow, Alison N. Hulme
Publikováno v:
The Journal of Biological Chemistry
Makou, E, Bailey, R G, Johnston, H, Parkin, J D, Hulme, A N, Hähner, G & Barlow, P N 2019, ' Combining SPR with atomic-force microscopy enables single-molecule insights into activation and suppression of the complement cascade ', Journal of Biological Chemistry, vol. 294, no. 52, pp. 20148-20163 . https://doi.org/10.1074/jbc.RA119.010913
Makou, E, Bailey, R G, Johnston, H, Parkin, J D, Hulme, A N, Hähner, G & Barlow, P N 2019, ' Combining SPR with atomic-force microscopy enables single-molecule insights into activation and suppression of the complement cascade ', Journal of Biological Chemistry, vol. 294, no. 52, pp. 20148-20163 . https://doi.org/10.1074/jbc.RA119.010913
This work was supported by Leverhulme Trust Grant RPG-2015-109. Activation and suppression of the complement system compete on every serum-exposed surface, host or foreign. Potentially harmful outcomes of this competition depend on surface molecules
Autor:
Heather Kerr, Andrew P. Herbert, Elisavet Makou, Dariusz Abramczyk, Talat H. Malik, Hannah Lomax-Browne, Yi Yang, Isabel Y. Pappworth, Harriet Denton, Anna Richards, Kevin J. Marchbank, Matthew C. Pickering, Paul N. Barlow
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Kerr, H, Herbert, A P, Makou, E, Abramczyk, D, Malik, T H, Lomax-Browne, H, Yang, Y, Pappworth, I Y, Denton, H, Richards, A, Marchbank, K J, Pickering, M C & Barlow, P N 2021, ' Murine factor H co-produced in yeast with protein disulfide isomerase ameliorated C3 dysregulation in factor H-Deficient mice ', Frontiers in Immunology, vol. 12, 681098 . https://doi.org/10.3389/fimmu.2021.681098
Frontiers in Immunology, Vol 12 (2021)
Kerr, H, Herbert, A P, Makou, E, Abramczyk, D, Malik, T H, Lomax-Browne, H, Yang, Y, Pappworth, I Y, Denton, H, Richards, A, Marchbank, K J, Pickering, M C & Barlow, P N 2021, ' Murine factor H co-produced in yeast with protein disulfide isomerase ameliorated C3 dysregulation in factor H-Deficient mice ', Frontiers in Immunology, vol. 12, 681098 . https://doi.org/10.3389/fimmu.2021.681098
Recombinant human factor H (hFH) has potential for treating diseases linked to aberrant complement regulation including C3 glomerulopathy (C3G) and dry age-related macular degeneration. Murine FH (mFH), produced in the same host, is useful for pre-cl
Autor:
Harris Ioannidis, Alessio De Simone, Arun A. Gupta, Jordi Juárez-Jiménez, Andrew Baldwin, Malcolm D. Walkinshaw, Gogulan Karunanithy, Julien Michel, Antonia S. J. S. Mey, Alison N. Hulme, Charis Georgiou, Paul N. Barlow
Publikováno v:
Chemical Science
Juárez-jiménez, J, Gupta, A A, Karunanithy, G, Mey, A S J S, Georgiou, C, Ioannidis, H, De Simone, A, Barlow, P N, Hulme, A N, Walkinshaw, M D, Baldwin, A J & Michel, J 2020, ' Dynamic design : Manipulation of millisecond timescale motions on the energy landscape of cyclophilin A ', Chemical Science, vol. 11, no. 10, pp. 2670-2680 . https://doi.org/10.1039/C9SC04696H
Dipòsit Digital de la UB
Universidad de Barcelona
Juárez-jiménez, J, Gupta, A A, Karunanithy, G, Mey, A S J S, Georgiou, C, Ioannidis, H, De Simone, A, Barlow, P N, Hulme, A N, Walkinshaw, M D, Baldwin, A J & Michel, J 2020, ' Dynamic design : Manipulation of millisecond timescale motions on the energy landscape of cyclophilin A ', Chemical Science, vol. 11, no. 10, pp. 2670-2680 . https://doi.org/10.1039/C9SC04696H
Dipòsit Digital de la UB
Universidad de Barcelona
Proteins need to interconvert between many conformations in order to function, many of which are formed transiently, and sparsely populated. Particularly when the lifetimes of these states approach the millisecond timescale, identifying the relevant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d0ba71167b38389d43b04acead7d98d
http://hdl.handle.net/2445/179325
http://hdl.handle.net/2445/179325