Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Paul Michael Steed"'
Autor:
Paul Michael Steed, Araz Eivazi, James Kung, Stephen K. Doberstein, François Erard, Jonathan Zalevsky, Laure Janot, Sergei A. Ezhevsky, Bernhard Ryffel, Christopher D. O'Brien, David E. Szymkowski, Duc-Hanh T. Nguyen, Thomas Secher
Publikováno v:
Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2007, 179 (3), pp.1872-83
Europe PubMed Central
Scopus-Elsevier
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2007, 179 (3), pp.1872-83
Europe PubMed Central
Scopus-Elsevier
TNF is a pleiotropic cytokine required for normal development and function of the immune system; however, TNF overexpression also induces inflammation and is associated with autoimmune diseases. TNF exists as both a soluble and a transmembrane protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4eb4653590b87e3947868abb033181c
https://hal.archives-ouvertes.fr/hal-00318488
https://hal.archives-ouvertes.fr/hal-00318488
Autor:
Paul Michael Steed, Navjiwan Mann, Bruce Beutler, Kasper Hoebe, Xin Du, Sophie Rutschmann, Bassil I. Dahiyat, Jonathan Zalevsky
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 176(12)
A dominant hypomorphic allele of Tnf, PanR1, was identified in a population of G1 mice born to N-ethyl-N-nitrosourea-mutagenized sires. Macrophages from homozygotes produced no detectable TNF bioactivity, although normal quantities of immunoreactive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60e25cb0d66a68b88295964dcad2f013
https://pubmed.ncbi.nlm.nih.gov/16751399
https://pubmed.ncbi.nlm.nih.gov/16751399
Autor:
Eugene Zhukovsky, Araz Eivazi, Alice Kim, Lisa Cherry, Omid Vafa, Peter Cheung, Jost Vielmetter, Paul Michael Steed, Sandhya Kashi, Arthur J. Chirino, Jonathan Zalevsky, John R. Desjarlais, Linus Hyun, Marian Hwang, Christina Abbott, Rend S. Hubert, Esther Kim, David E. Szymkowski, Sarah X. Gao, C. O'Brien, James Kung, Hyo H. Chung, Malú G. Tansey, Donald O'keefe, Sean Yoder, Stephen K. Doberstein, David F. Carmichael, Karen Singer, Anton Filikov, T. Umesh S. Muchhal, Duc-Hanh T. Nguyen, Cheryl Chan, Sabrina P. Martinez, Bassil I. Dahiyat
Publikováno v:
Science (New York, N.Y.). 301(5641)
Tumor necrosis factor (TNF) is a key regulator of inflammatory responses and has been implicated in many pathological conditions. We used structure-based design to engineer variant TNF proteins that rapidly form heterotrimers with native TNF to give
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dde7bbe8096068d11314ae2a672bda88
https://pubmed.ncbi.nlm.nih.gov/14512626
https://pubmed.ncbi.nlm.nih.gov/14512626