Výsledky vyhledávání - "Paul Melançon"

BioID Performed on Golgi Enriched Fractions Identify C10orf76 as a GBF1 Binding Protein Essential for Golgi Maintenance and Secretion

Autor: Estelle M.N. Laurent, Roberta Le, Etienne Coyaud, Khadra Ahmed, Brian Raught, Calvin J. Chan, Kaylan Burns, Paul Melançon

Publikováno v: Mol Cell Proteomics

The Golgi-specific Brefeldin-A resistance factor 1 (GBF1) is the only large GEF that regulates Arf activation at the cis-Golgi and is actively recruited to membranes on an increase in Arf-GDP. Recent studies have revealed that GBF1 recruitment requir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26aba4ddcd7b04b5df4a00cb60ca076e
https://pubmed.ncbi.nlm.nih.gov/31519766

Zobrazit plný text záznamu

The Arf-GDP-regulated recruitment of GBF1 to Golgi membranes requires domains HDS1 and HDS2 and a Golgi-localized protein receptor

Autor: Ghazal Babolmorad, Calvin J. Chan, Alexandra Bain, Katherine Yurkiw, Paul Melançon, Douglas Quilty

Publikováno v: Journal of Cell Science

We previously proposed a novel mechanism by which the enzyme Golgi-specific Brefeldin A resistance factor 1 (GBF1) is recruited to the membranes of the cis-Golgi, based on in vivo experiments. Here, we extended our in vivo analysis on the production

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b327dfe9e75945c82dc29a3b26dded2
http://europepmc.org/articles/PMC6398479

Zobrazit plný text záznamu

Arf3 Is Activated Uniquely at thetrans-Golgi Network by Brefeldin A-inhibited Guanine Nucleotide Exchange Factors

Autor: Justin Chun, Joel B. Dacks, Paul Melançon, Ian Clarke, David W. Chen, Nathan Summerfeldt, Florin Manolea

Publikováno v: Molecular Biology of the Cell

Arf3 associates with the TGN in a manner that is both temperature-sensitive and uniquely dependent on BIGs. TGN localization and release at 20°C are readily separated and depend on pairs of residues absolutely conserved and unique to Arf3 present at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8424be298e53af2a2f4601817d59248d
https://doi.org/10.1091/mbc.e10-01-0016

Zobrazit plný text záznamu

ADP-ribosylation Factor 1 Controls the Activation of the Phosphatidylinositol 3-Kinase Pathway to Regulate Epidermal Growth Factor-dependent Growth and Migration of Breast Cancer Cells

Autor: Audrey Claing, Paul Melançon, Pierre-Luc Boulay, Mathieu Cotton

Publikováno v: Journal of Biological Chemistry. 283:36425-36434

Activation of intracellular signaling pathways by growth factors is one of the major causes of cancer development and progression. Recent studies have demonstrated that monomeric G proteins of the Ras family are key regulators of cell proliferation,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0c9168ca20db5e01c100e5f491f72b4
https://doi.org/10.1074/jbc.m803603200

Zobrazit plný text záznamu

GBF1, a cis-Golgi and VTCs-localized ARF-GEF, is implicated in ER-to-Golgi protein traffic

Autor: Paul Melançon, Xinhua Zhao, David J. Shields, John F. Presley, Justin Chun, Alejandro Claude

Publikováno v: JOURNAL OF CELL SCIENCE
Artículos CONICYT
CONICYT Chile
instacron:CONICYT

The formation and maturation of membrane carriers that transport cargo from the ER to the Golgi complex involves the sequential action of the coat protein complexes COPII and COPI. Recruitment of COPI to nascent carriers requires activation of ADP-ri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1313a88f0b386b2e7b7331c0f45e4ae
https://doi.org/10.1242/jcs.03173

Zobrazit plný text záznamu

The Arf6 GEF GEP100/BRAG2 Regulates Cell Adhesion by Controlling Endocytosis of β1 Integrins

Autor: Kim Ly, James E. Casanova, Troy K. R. Lasell, Paul Melançon, Jillian L. Dunphy, Radim Moravec

Publikováno v: Current Biology. 16:315-320

SummaryThe small GTPase Arf6 has been shown to regulate the post-endocytic trafficking of a subset of membrane proteins, including β1 integrins, and inhibition of Arf6 function impairs both cell adhesion and motility [1]. The activity of Arf GTPases

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fabd10c5cf0eaeeb693b6f69a97abc45
https://doi.org/10.1016/j.cub.2005.12.032

Zobrazit plný text záznamu

Reticulon 3 is involved in membrane trafficking between the endoplasmic reticulum and Golgi

Autor: Masami Nagahama, Yuichi Wakana, Hans-Peter Hauri, Mitsuo Tagaya, Kiyotaka Hatsuzawa, Paul Melançon, Ken-ichi Nakajima, Satoshi Koyama, Katsuko Tani

Publikováno v: Biochemical and Biophysical Research Communications. 334:1198-1205

Reticulons (RTNs) constitute a family of endoplasmic reticulum (ER)-associated proteins with a reticular distribution. Despite the implication of their neuronal isoforms in axonal regeneration, the function of their widely expressed isoforms is large

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05a13b0ff553ae9e2848271d04eed4c7
https://doi.org/10.1016/j.bbrc.2005.07.012

Zobrazit plný text záznamu

Characterization of alternatively spliced and truncated forms of the Arf guanine nucleotide exchange factor GBF1 defines regions important for activity

Autor: Paul Melançon, Alejandro Claude, Bao-Ping Zhao

Publikováno v: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Artículos CONICYT
CONICYT Chile
instacron:CONICYT

Analysis of multiple transcripts for the Arf-specific guanine nucleotide exchange factor GBF1 identified three positions displaying small in-frame deletions and insertions. Sequencing of genomic DNA for CHO GBF1 and analysis of the human gene establi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8809e312dd2116f31209f23eb62f857a
https://doi.org/10.1016/s0006-291x(03)00316-4

Zobrazit plný text záznamu

Localization of Large ADP-Ribosylation Factor-Guanine Nucleotide Exchange Factors to Different Golgi Compartments: Evidence for Distinct Functions in Protein Traffic

Autor: Paul Melançon, Xinhua Zhao, Troy K. R. Lasell

Publikováno v: Molecular Biology of the Cell. 13:119-133

Activation of several ADP-ribosylation factors (ARFs) by guanine nucleotide exchange factors (GEFs) regulates recruitment of coat proteins (COPs) on the Golgi complex and is generally assumed to be the target of brefeldin A (BFA). The large ARF-GEFs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c6f170c4a6aa2b586c5f9b67c457ae6
https://doi.org/10.1091/mbc.01-08-0420

Zobrazit plný text záznamu

Scyl1 scaffolds class II Arfs to specific subcomplexes of coatomer through the γ-COP appendage domain

Autor: Jason N R, Hamlin, Lena K, Schroeder, Maryam, Fotouhi, Hatem, Dokainish, Maria S, Ioannou, Martine, Girard, Nathan, Summerfeldt, Paul, Melançon, Peter S, McPherson

Publikováno v: Journal of cell science. 127(Pt 7)

Coatomer (COPI)-coated vesicles mediate membrane trafficking in the early secretory pathway. There are at least three subclasses of COPI coats and two classes of Arf GTPases that couple COPI coat proteins to membranes. Whether mechanisms exist to lin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cb9d330d3494834226c3d13da712598e
https://pubmed.ncbi.nlm.nih.gov/24481816

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání