Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Paul McKeigue"'
Autor:
Xue Li, Xiangrui Meng, Yazhou He, Athina Spiliopoulou, Maria Timofeeva, Wei-Qi Wei, Aliya Gifford, Tian Yang, Tim Varley, Ioanna Tzoulaki, Peter Joshi, Joshua C Denny, Paul Mckeigue, Harry Campbell, Evropi Theodoratou
Publikováno v:
PLoS Medicine, Vol 16, Iss 10, p e1002937 (2019)
BackgroundThe role of urate in cardiovascular diseases (CVDs) has been extensively investigated in observational studies; however, the extent of any causal effect remains unclear, making it difficult to evaluate its clinical relevance.Methods and fin
Externí odkaz:
https://doaj.org/article/373469245b9842489c08689cd370e9d0
Autor:
Samira Bell, Bassam Farran, Stuart McGurnaghan, Rory J. McCrimmon, Graham P Leese, John R Petrie, Paul McKeigue, Naveed Sattar, Sarah Wild, John McKnight, Robert Lindsay, Helen M. Colhoun, Helen Looker
Publikováno v:
BMC Nephrology, Vol 18, Iss 1, Pp 1-8 (2017)
Abstract Background Whether metformin precipitates lactic acidosis in patients with chronic kidney disease (CKD) remains under debate. We examined whether metformin use was associated with an increased risk of acute kidney injury (AKI) as a proxy for
Externí odkaz:
https://doaj.org/article/82e6120d7ce74724820ef0a5563b18b5
Autor:
James S Floyd, Katarzyna M Bloch, Jennifer A Brody, Cyrielle Maroteau, Moneeza K Siddiqui, Richard Gregory, Daniel F Carr, Mariam Molokhia, Xiaoming Liu, Joshua C Bis, Ammar Ahmed, Xuan Liu, Pär Hallberg, Qun-Ying Yue, Patrik K E Magnusson, Diane Brisson, Kerri L Wiggins, Alanna C Morrison, Etienne Khoury, Paul McKeigue, Bruno H Stricker, Maryse Lapeyre-Mestre, Susan R Heckbert, Arlene M Gallagher, Hector Chinoy, Richard A Gibbs, Emmanuelle Bondon-Guitton, Russell Tracy, Eric Boerwinkle, Daniel Gaudet, Anita Conforti, Tjeerd van Staa, Colleen M Sitlani, Kenneth M Rice, Anke-Hilse Maitland-van der Zee, Mia Wadelius, Andrew P Morris, Munir Pirmohamed, Colin A N Palmer, Bruce M Psaty, Ana Alfirevic, PREDICTION-ADR Consortium and EUDRAGENE
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0218115 (2019)
AimsStatin-related myopathy (SRM), which includes rhabdomyolysis, is an uncommon but important adverse drug reaction because the number of people prescribed statins world-wide is large. Previous association studies of common genetic variants have had
Externí odkaz:
https://doaj.org/article/2ad0f040dcd841839a2fd08139da5390
Publikováno v:
Journal of Systemics, Cybernetics and Informatics, Vol 9, Iss 6, Pp 1-8 (2011)
We describe a unified computational framework for learning causal dependencies between genotypes, biomarkers, and phenotypic outcomes from large-scale data. In contrast to previous studies, our framework allows for noisy measurements, hidden confound
Externí odkaz:
https://doaj.org/article/1f1314018d804f3f9105ab19ab6c07eb
Autor:
Anne Eriksen, Therese Tillin, Laura O'Connor, Soren Brage, Alun Hughes, Jamil Mayet, Paul McKeigue, Peter Whincup, Nish Chaturvedi, Nita G Forouhi
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0117364 (2015)
There is consistent evidence on the impact of health behaviours on risk of cardiovascular disease (CVD) in European populations. As South Asians in the UK have an excess risk of CVD and coronary heart disease (CHD) compared to Europeans, we investiga
Externí odkaz:
https://doaj.org/article/b2077bc41130465ca0f447a4594de80b
Autor:
Albert M Levin, Michael C Iannuzzi, Courtney G Montgomery, Sheri Trudeau, Indrani Datta, Indra Adrianto, Dhananjay A Chitale, Paul McKeigue, Benjamin A Rybicki
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92646 (2014)
Sarcoidosis is a complex, multi-organ granulomatous disease with a likely genetic component. West African ancestry confers a higher risk for sarcoidosis than European ancestry. Admixture mapping provides the most direct method to locate genes that un
Externí odkaz:
https://doaj.org/article/a645e9c1ca644d58b75d516b25ff95b8
Autor:
Gordan Lauc, Jennifer E Huffman, Maja Pučić, Lina Zgaga, Barbara Adamczyk, Ana Mužinić, Mislav Novokmet, Ozren Polašek, Olga Gornik, Jasminka Krištić, Toma Keser, Veronique Vitart, Blanca Scheijen, Hae-Won Uh, Mariam Molokhia, Alan Leslie Patrick, Paul McKeigue, Ivana Kolčić, Ivan Krešimir Lukić, Olivia Swann, Frank N van Leeuwen, L Renee Ruhaak, Jeanine J Houwing-Duistermaat, P Eline Slagboom, Marian Beekman, Anton J M de Craen, André M Deelder, Qiang Zeng, Wei Wang, Nicholas D Hastie, Ulf Gyllensten, James F Wilson, Manfred Wuhrer, Alan F Wright, Pauline M Rudd, Caroline Hayward, Yurii Aulchenko, Harry Campbell, Igor Rudan
Publikováno v:
PLoS Genetics, Vol 9, Iss 1, p e1003225 (2013)
Glycosylation of immunoglobulin G (IgG) influences IgG effector function by modulating binding to Fc receptors. To identify genetic loci associated with IgG glycosylation, we quantitated N-linked IgG glycans using two approaches. After isolating IgG
Externí odkaz:
https://doaj.org/article/b199e4ae942e4dc2a7fbc3d1609faf09
Autor:
Lina Zgaga, Felix Agakov, Evropi Theodoratou, Susan M Farrington, Albert Tenesa, Malcolm G Dunlop, Paul McKeigue, Harry Campbell
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63475 (2013)
Vitamin D deficiency has been associated with increased risk of colorectal cancer (CRC), but causal relationship has not yet been confirmed. We investigate the direction of causation between vitamin D and CRC by extending the conventional approaches
Externí odkaz:
https://doaj.org/article/1204b8462fa84379a8959e9b38e308e1
Autor:
Evropi Theodoratou, Tom Palmer, Lina Zgaga, Susan M Farrington, Paul McKeigue, Farhat V N Din, Albert Tenesa, George Davey-Smith, Malcolm G Dunlop, Harry Campbell
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e37662 (2012)
Vitamin D deficiency has been associated with several common diseases, including cancer and is being investigated as a possible risk factor for these conditions. We reported the striking prevalence of vitamin D deficiency in Scotland. Previous epidem
Externí odkaz:
https://doaj.org/article/3d799966e8594960a280701a235d7486
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e14588 (2011)
ObjectivesTo determine the main predictors of all-cause and cardiovascular (CV) mortality in a rural West Indian population in Plymouth, Tobago over 30 years.MethodsQuestionnaire survey for CV risk factors and alcohol consumption patterns administere
Externí odkaz:
https://doaj.org/article/054f71860b674a76b81b06b228e5feb0