Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Paul Machui"'
Autor:
Philipp Ochtrop, Jahaziel Jahzerah, Paul Machui, Isabelle Mai, Dominik Schumacher, Jonas Helma, Marc-André Kasper, Christian P. R. Hackenberger
Publikováno v:
Chemical Science. 14:2259-2266
Compact phosphonamidate building blocks enable the simple construction of homogeneous DAR8 ADCs from native antibodies and hydrophobic payloads. The resulting ADCs exhibit excellent in vivo stability, clearance rates and antitumor activity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c030d1f8e8859610dcb28140584d7e95
https://doi.org/10.1039/d2sc05678j
https://doi.org/10.1039/d2sc05678j
Publikováno v:
The Journal of Organic Chemistry. 84:1440-1447
A biocatalytic reduction of 2H-1,4-benzoxazines using imine reductases is reported. This process enables a smooth and enantioselective synthesis of the resulting cyclic amines under mild conditions in aqueous media by means of a catalytic amount of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29331dfacdc9fb57af76ef0620b5fae0
https://doi.org/10.1021/acs.joc.8b02867
https://doi.org/10.1021/acs.joc.8b02867