Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Paul M. van Midwoud"'
Autor:
Stefan M. Cokelaere, Wilhelmina M.G.A.C. Groen, Saskia G.M. Plomp, Janny C. de Grauw, Paul M. van Midwoud, Harrie H. Weinans, Chris H.A. van de Lest, Marianna A. Tryfonidou, P. René van Weeren, Nicoline M. Korthagen
Publikováno v:
Pharmaceutics, Vol 13, Iss 9, p 1438 (2021)
There is an increasing interest in controlled release systems for local therapy in the treatment of human and equine joint diseases, aiming for optimal intra-articular concentrations with no systemic side effects. In this study, the intra-articular t
Externí odkaz:
https://doaj.org/article/b0c535246d5d400ba033ffb555f46796
Autor:
Paul M. van Midwoud, Kristin Schirmer, Danielle J. Madureira, Shana J. Sturla, Damian E. Helbling, Frederik T. Weiss
Publikováno v:
Chemical Research in Toxicology. 27:443-453
Cell-based models are important for deriving mechanistic information about stress response pathways that have evolved to protect cells from toxic insult, such as exposure to environmental pollutants. One determinant of the stress response is the amou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f10714a00d0f64e574ee707a6379b5e8
https://doi.org/10.1021/tx400446q
https://doi.org/10.1021/tx400446q
Autor:
Paul M. van Midwoud, Inge A. M. de Graaf, Sylvia A. Blomsma, Geny M. M. Groothuis, Gregory M. Fahy, Na Guan
Publikováno v:
Cryobiology, 65(3), 179-187
Successful vitrification of organ slices is hampered by both osmotic stress and chemical toxicity of cryoprotective agents (CPAs). In the present study, we focused on the effect of osmotic stress on the viability of precision-cut liver slices (PCLS)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1b08cd8bdb9ef6124c531287dac3016
https://doi.org/10.1016/j.cryobiol.2012.05.011
https://doi.org/10.1016/j.cryobiol.2012.05.011
Publikováno v:
Journal of Laboratory Automation, 16(6), 468-476. SAGE Publications Inc.
Early information on the metabolism and toxicity properties of new drug candidates is crucial for selecting the right candidates for further development. Preclinical trials rely on cell-based in vitro tests and animal studies to characterize the in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f68a74e2e1299cde5cd0309f5693e70
https://doi.org/10.1016/j.jala.2011.07.003
https://doi.org/10.1016/j.jala.2011.07.003
Publikováno v:
Biotechnology and Bioengineering, 105(1), 184-194. Wiley-Blackwell
Early detection of kinetic, metabolic, and toxicity (ADME-Tox) profiles for new drug candidates is of crucial importance during drug development. This article describes a novel in vitro system for the incubation of precision-cut liver slices (PCLS) u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbf0099275679694f890d222557d8c79
https://doi.org/10.1002/bit.22516
https://doi.org/10.1002/bit.22516
Autor:
Laurent Rieux, Paul M. van Midwoud, Rainer Bischoff, H.A.G. Niederländer, Elisabeth Verpoorte
Publikováno v:
Journal of Proteome Research, 6(2), 781-791. NLM (Medline)
Poor repeatability of peak areas is a problem frequently encountered in peptide analysis with nanoLiquid Chromatography coupled on-line with Mass Spectrometry (nanoLC-MS). As a result, quantitative analysis will be seriously hampered unless the obser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::171a4aaed6d2ff54cdbfd7230378693d
https://doi.org/10.1021/pr0604099
https://doi.org/10.1021/pr0604099
Illudin S and its semisynthetic analogue acylfulvene (AF) are structurally similar but elicit different biological responses. AF is a bioreductive alkylating anticancer agent with a favorable therapeutic index, while illudin S is in general highly to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cb80432899c89e16f1b774b73b1664f
https://europepmc.org/articles/PMC3858472/
https://europepmc.org/articles/PMC3858472/
Autor:
Paul M. van Midwoud, Elisabeth Verpoorte, Marjolijn T. Merema, Arnout Janse, Geny M. M. Groothuis
Publikováno v:
Analytical Chemistry, 84(9), 3938-3944. AMER CHEMICAL SOC INC
Microfluidic technology is providing new routes toward advanced cell and tissue culture models to better understand human biology and disease. Many advanced devices have been made from poly(dimethylsiloxane) (PDMS) to enable experiments, for example,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::495a6199e9b8221da2f67a74e6213556
https://pubmed.ncbi.nlm.nih.gov/22444457
https://pubmed.ncbi.nlm.nih.gov/22444457
Autor:
Paul M. van Midwoud, Niek Verweij, Elisabeth Verpoorte, Geny M. M. Groothuis, Marjolijn T. Merema
Publikováno v:
Biotechnology and Bioengineering, 108(6), 1404-1412. Wiley-Blackwell
A microfluidic-based biochip made of poly(dimethylsiloxane) was recently reported for the first time by us for the incubation of precision-cut liver slices (PCLS). In this system, PCLS are continuously exposed to flow, to keep the incubation environm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b268907a846476b352b467dc0a171158
https://research.rug.nl/en/publications/2a352b04-0590-402a-83f9-31694b9fbb76
https://research.rug.nl/en/publications/2a352b04-0590-402a-83f9-31694b9fbb76
Autor:
Paul M. van Midwoud, Marjolijn T. Merema, Elisabeth Verpoorte, Geny M. M. Groothuis, Inge A. M. de Graaf, Joost Janssen
Publikováno v:
Analytical Chemistry, 83(1), 84-91. AMER CHEMICAL SOC INC
A novel approach for on-line monitoring of drug metabolism in continuously perifused, precision-cut liver slices (PCLS) in a microfluidic system has been developed using high-performance liquid chromatography with UV detection (HPLC-UV). In this appr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47eaf20251706faeb645abe341a7f240
https://research.rug.nl/en/publications/abfeddf5-34e4-49ad-8354-19b8b7ddee79
https://research.rug.nl/en/publications/abfeddf5-34e4-49ad-8354-19b8b7ddee79