Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Paul M. Watt"'
Autor:
Vikrant Kumar, Bryn Hardwick, Saranya Giridharan, Sneha Sudhakar, Markus Muellner, Manjunath A. Hurakadli, Ashok R. Venkitaraman, Gayathri Sadasivam, T.K. Prasad, Neelagandan Kamariah, Grahame J. McKenzie, Alex T. Crooks, Subashini Mathivanan, Paul M. Watt, Miguel Coelho, Sneha Bairy, Nadia Milech, Chandan Mithra, Christopher J. Torrance, Amy Emery, Kavitha Bharatham
Publikováno v:
Cell Chemical Biology
Summary Genetic screening technologies to identify and validate macromolecular interactions (MMIs) essential for complex pathways remain an important unmet need for systems biology and therapeutics development. Here, we use a library of peptides from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82261f81e78bea18e12f385b6c100941
https://doi.org/10.1016/j.chembiol.2021.05.009
https://doi.org/10.1016/j.chembiol.2021.05.009
Publikováno v:
Current Opinion in Chemical Biology. 38:127-133
Phylomers are peptides derived from biodiverse protein fragments. Genetically encoded Phylomer libraries have been constructed, containing hundreds of billions of peptides derived from virtually all of the few thousand fold families found in the prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82f2db05d4eb66ae735caa4b9da1313b
https://doi.org/10.1016/j.cbpa.2017.03.016
https://doi.org/10.1016/j.cbpa.2017.03.016
Autor:
Paula T. Cunningham, Mark Anastasas, Tatjana Heinrich, Laura Florez, Danie Champain, Theresa Connor, Paul M. Watt, Nadia Milech, Scott Winslow, Abbie M. Adams, Karen M. Kroeger, Richard W. Francis, Brooke A. C. Longville, Robert E. Dewhurst, Shane R. Stone, Yew Foon Tan, M. Scobie, Clinton M. Hall, Helena M. Viola, Maria Kerfoot, Livia C. Hool, Heique M. Bogdawa, Arne Skerra, Katrin Hoffmann, Ferrer Ong, Volker Morath, Suzy M. Juraja, Sue Fletcher, Gregory A. Weiss, Richard Hopkins
Publikováno v:
Scientific reports, vol 8, iss 1
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-16 (2018)
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-16 (2018)
Cell penetrating peptides (CPPs) offer great potential to deliver therapeutic molecules to previously inaccessible intracellular targets. However, many CPPs are inefficient and often leave their attached cargo stranded in the cell’s endosome. We re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2982281cc58305b13bc410a28e61452e
https://escholarship.org/uc/item/9539k69b
https://escholarship.org/uc/item/9539k69b
Autor:
Tatjana Heinrich, Renae K. Barr, Richard W. Francis, Heique M. Bogdawa, Nadia Milech, Shane R. Stone, Robert E. Dewhurst, Paul M. Watt
Phylomers are peptides derived from fragments of proteins encoded by biodiverse genomes. Phylomer libraries were devised as a strategy to enable screening of a diverse array of peptides representing sequences that form secondary and super-secondary s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f7cd2b256feed269730aa0148f5dbec
https://doi.org/10.1039/9781788011532-00497
https://doi.org/10.1039/9781788011532-00497
Previous work has suggested that the promoter regions of the human embryonic zeta 2 and epsilon globin genes contain negative regulatory regions that could play a role in the repression of these genes in postembryonic erythroblasts. We have examined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea1ca3f6e429db9f1d2d299719071bf2
https://ora.ox.ac.uk/objects/uuid:b077e58d-0d79-4742-9a57-2fc56d1640c9
https://ora.ox.ac.uk/objects/uuid:b077e58d-0d79-4742-9a57-2fc56d1640c9
Autor:
Yew-Foon Tan, Mark Anastasas, Ferrer Ong, M. Scobie, Paul M. Watt, Tatjana Heinrich, Richard Hopkins, Maria Kerfoot, Scott Winslow, Wayne R. Thomas, Karen M. Kroeger, Nadia Milech, Paula T. Cunningham, Shane R. Stone, Brooke A. C. Longville, Theresa Connor, Katrin Hoffmann, Heique M. Bogdawa
Publikováno v:
Scientific Reports
Efficient cargo uptake is essential for cell-penetrating peptide (CPP) therapeutics, which deliver widely diverse cargoes by exploiting natural cell processes to penetrate the cell’s membranes. Yet most current CPP activity assays are hampered by l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3931f4fcfdf9f65101928a87029ea7c6
Autor:
Amanda J. Meade, Bruno P. Meloni, Paul M. Watt, Nadia Milech, Neville W. Knuckey, William R Gow, Kym Campbell
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 31:e1-e8
In this study, we have assessed the ability of two TAT-fused peptides PYC36d-TAT and JNKI-1d-TAT (JNKI-1 or XG-102), which respectively inhibit jun proto-oncogene (c-Jun) and c-Jun N-terminal kinase (JNK) activation, to reduce infarct volume and impr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::838844a61dd88907db6f52ef0bd77160
https://doi.org/10.1038/jcbfm.2011.140
https://doi.org/10.1038/jcbfm.2011.140
Autor:
Bruno Catimel, Heung-Chin Cheng, Nicole Church, Dominic C.H. Ng, Marie A. Bogoyevitch, Daisy S. Lio, Paul M. Watt, Matthew A. Perugini, Kevin R.W. Ngoei, Con Dogovski
Publikováno v:
Biochemical Journal. 434:399-413
An improved understanding of the roles of protein kinases in intracellular signalling and disease progression has driven significant advances in protein kinase inhibitor discovery. Peptide inhibitors that target the kinase protein substrate-binding s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25da0f2bb91947194dcb0a2a3d9f574f
https://doi.org/10.1042/bj20101244
https://doi.org/10.1042/bj20101244
Publikováno v:
International Journal of Peptide Research and Therapeutics. 17:1-6
Using acute and delayed in vitro ischaemia models we evaluated the neuroprotective efficacy of five peptides (PYC19D-TAT, PYC35D-TAT, PYC36D-TAT, PYC38D-TAT, PYC41D-TAT) previously demonstrated to down-regulate AP-1 activation (e.g. c-Jun/c-Fos activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0590785228c63aa2930ddfbee1a2c83
https://doi.org/10.1007/s10989-010-9234-8
https://doi.org/10.1007/s10989-010-9234-8
Publikováno v:
Brain Research. 1360:8-16
This study has assessed the neuroprotective efficacy of five AP-1 inhibitory peptides in an in vitro excitotoxicity model. The five AP-1 inhibitory peptides and controls of the JNK inhibitor peptide (JNKI-1D-TAT) and TAT cell-penetrating-peptide were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::353cfed489f98059714cb62c2711fc4e
https://doi.org/10.1016/j.brainres.2010.09.007
https://doi.org/10.1016/j.brainres.2010.09.007