Výsledky vyhledávání - "Paul M. Waterman"

MPYS, a Novel Membrane Tetraspanner, Is Associated with Major Histocompatibility Complex Class II and Mediates Transduction of Apoptotic Signals

Autor: Cindy M. Short, Paul M. Waterman, Lei Jin, Nichole Reisdorph, Karen R. Jonscher, John C. Cambier

Publikováno v: Molecular and Cellular Biology. 28:5014-5026

Although the best-defined function of type II major histocompatibility complex (MHC-II) is presentation of antigenic peptides to T lymphocytes, these molecules can also transduce signals leading alternatively to cell activation or apoptotic death. MH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28853499c535b96f9ce90d8a49872bab
https://doi.org/10.1128/mcb.00640-08

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Simian/Human Immunodeficiency Virus89.6Expressing the Chemokine Genes MIP-1α, RANTES, or Lymphotactin

Autor: C. David Pauza, Paul M. Waterman, Moiz Kitabwalla, Ilia Tikhonov

Publikováno v: Viral Immunology. 16:35-44

We constructed replication competent, attenuated, nef-deleted SHIV(89.6) that express the rhesus macaque chemokine genes MIP-1alpha, RANTES, or LTN from the nef region. The chemokine inserts were stable during several passages in CEMx174 cells and th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d597a2b77ad972d28d4c6ff5cbbaab8b
https://doi.org/10.1089/088282403763635438

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Lymphocyte Activation during Acute Simian/Human Immunodeficiency Virus SHIV 89.6PD Infection in Macaques

Autor: Charles C. Brown, Marta Dykhuizen, Moiz Kitabwalla, Marianne Wallace, Jacque Mitchen, Douglas Horejsh, Mahmoud Djavani, Paul M. Waterman, Parul Trivedi, C. David Pauza

Publikováno v: Journal of Virology. 73:10236-10244

Host-virus interactions control disease progression in human immunodeficiency virus-infected human beings and in nonhuman primates infected with simian or simian/human immunodeficiency viruses (SHIV). These interactions evolve rapidly during acute in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6983034d87fb3998355d01794fd33619
https://doi.org/10.1128/jvi.73.12.10236-10244.1999

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Acute Effects of Pathogenic Simian-Human Immunodeficiency Virus Challenge on Vaccine-Induced Cellular and Humoral Immune Responses to Gag in Rhesus Macaques

Autor: Krista K. Steger, C. David Pauza, Paul M. Waterman

Publikováno v: Journal of Virology. 73:1853-1859

Simian-human immunodeficiency virus (SHIV) infection in macaques provides a convenient model for testing vaccine efficacy and for understanding viral pathogenesis in AIDS. We immunized macaques with recombinant, Salmonella typhimurium (expressing Gag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2d67737a5af7eaba73de9cd7b738aac
https://doi.org/10.1128/jvi.73.3.1853-1859.1999

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The inositol 5-phosphatase SHIP-1 and adaptors Dok-1 and 2 play central roles in CD4-mediated inhibitory signaling

Autor: Erin Brandl, John C. Cambier, Paul M. Waterman, Susanne Marschner

Publikováno v: Immunology letters. 143(1)

CD4 functions to enhance the sensitivity of T cells to antigenic peptide/MHC class II. However, if aggregated in isolation, e.g. in the absence of T cell receptor (TCR), CD4 can transduce yet undefined signals that lead to T cell unresponsiveness to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2f36228840640a379d629fa73400964
https://pubmed.ncbi.nlm.nih.gov/22370159

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The conundrum of inhibitory signaling by ITAM-containing immunoreceptors: potential molecular mechanisms

Autor: John C. Cambier, Paul M. Waterman

Publikováno v: FEBS letters. 584(24)

Immunoreceptor signals must be appropriately transduced and regulated to achieve effective immunity while controlling inflammation and autoimmunity. It is generally held that these processes are mediated by the interplay of distinct activating and in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03a0f403c212ebb67f50867328130b39
https://pubmed.ncbi.nlm.nih.gov/20875413

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Effects of virus burden and chemokine expression on immunity to SHIV in nonhuman primates

Autor: Ilia Tikhonov, Paul M. Waterman, Glen S. Hatfield, Peter Evans, Joseph Bryant, Moiz Kitabwalla, Yichen Lu, C. David Pauza

Publikováno v: Viral immunology. 17(4)

HIV-1 vaccine candidates are designed to elicit Type 1 immune responses, including cytotoxic T cells and neutralizing antibodies. The type of immune response is influenced by many factors, including the levels of antigen expression and production of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0b1f405ebaaa8de36fe445e05a3a02e
https://pubmed.ncbi.nlm.nih.gov/15671751

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