Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Paul M. Tyler"'
Autor:
Andrew J. Takeda, Timothy J. Maher, Yu Zhang, Stephen M. Lanahan, Molly L. Bucklin, Susan R. Compton, Paul M. Tyler, William A. Comrie, Makoto Matsuda, Kenneth N. Olivier, Stefania Pittaluga, Joshua J. McElwee, Debra A. Long Priel, Douglas B. Kuhns, Roger L. Williams, Peter J. Mustillo, Matthias P. Wymann, V. Koneti Rao, Carrie L. Lucas
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Causally linking a mutation to clinical phenotypes in rare hereditary diseases is both challenging and illuminating. Here the authors identify PI3Kɣ mutations in a patient with immune dysregulation, and recapitulate the phenotypes in PI3Kɣ-deficien
Externí odkaz:
https://doaj.org/article/e5661652c92a434e8616129d00386c3f
Autor:
Stephanie K. Dougan, Hidde L. Ploegh, Ulrich H. von Andrian, Quang-De Nguyen, Mohammad Rashidian, Mariah M. Servos, Paul M. Tyler, Olga Blomberg, Novalia Pishesha, Lestat Ali, Patrick T. Bruck, Munir M. Mosaheb, Hee-Jin Jeong, Jessica R. Ingram, Michael Dougan
S6. A12-IFNγ alters the tumor microenvironment in KPC organoid model of pancreatic cancer.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eeab2ddf65065bd70c2ec3f5c4c9796
https://doi.org/10.1158/2326-6066.22540097
https://doi.org/10.1158/2326-6066.22540097
Autor:
Stephanie K. Dougan, Michael E. Birnbaum, Patrick T. Bruck, M. Aladdin Bhuiyan, Katherine S. Ventre, Lestat R. Ali, Mariah M. Servos, Paul M. Tyler, Christine A. Devlin, Eleanor Clancy-Thompson
Supplemental Table and Figures S1 and S2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cb2de0a695d87c8bb9950e811a78a50
https://doi.org/10.1158/2326-6066.22539983.v1
https://doi.org/10.1158/2326-6066.22539983.v1
Autor:
Stephanie K. Dougan, Michael E. Birnbaum, Patrick T. Bruck, M. Aladdin Bhuiyan, Katherine S. Ventre, Lestat R. Ali, Mariah M. Servos, Paul M. Tyler, Christine A. Devlin, Eleanor Clancy-Thompson
T-cell priming occurs when a naïve T cell recognizes cognate peptide–MHC complexes on an activated antigen-presenting cell. The circumstances of this initial priming have ramifications on the fate of the newly primed T cell. Newly primed CD8+ T ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17d24f9319967b5545096fed77421740
https://doi.org/10.1158/2326-6066.c.6549242.v1
https://doi.org/10.1158/2326-6066.c.6549242.v1
Autor:
Stephanie K. Dougan, Michael Dougan, Yosef Landesman, Sharon Sacham, Trinayan Kashyap, Boris Klebanov, Romy C. de Vries, Mariah M. Servos, Paul M. Tyler
Supplemental Figure 1: Response to immunization is only modestly affected by selinexor.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7e3dd2782c79ebaa858be1024365729
https://doi.org/10.1158/1535-7163.22509346
https://doi.org/10.1158/1535-7163.22509346
Autor:
Stephanie K. Dougan, Michael E. Birnbaum, Patrick T. Bruck, M. Aladdin Bhuiyan, Katherine S. Ventre, Lestat R. Ali, Mariah M. Servos, Paul M. Tyler, Christine A. Devlin, Eleanor Clancy-Thompson
Supplemental Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cc3ff4b43ca151344dfeb6a8c471bd9
https://doi.org/10.1158/2326-6066.22539980
https://doi.org/10.1158/2326-6066.22539980
Autor:
Stephanie K. Dougan, Michael Dougan, Yosef Landesman, Sharon Sacham, Trinayan Kashyap, Boris Klebanov, Romy C. de Vries, Mariah M. Servos, Paul M. Tyler
Supplemental Figure 3: Degranulation of effector CD8 T cells is affected by selinexor.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a22bc7dcb83589955473e577e58b61a
https://doi.org/10.1158/1535-7163.22509340.v1
https://doi.org/10.1158/1535-7163.22509340.v1
Autor:
Stephanie K. Dougan, Michael Dougan, Yosef Landesman, Sharon Sacham, Trinayan Kashyap, Boris Klebanov, Romy C. de Vries, Mariah M. Servos, Paul M. Tyler
Supplemental Figure 2: IFNγ secretion is impaired by selinexor.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1240f94ccb7d588d494dd8aa1380214
https://doi.org/10.1158/1535-7163.22509343.v1
https://doi.org/10.1158/1535-7163.22509343.v1
Autor:
Stephanie K. Dougan, Michael Dougan, Yosef Landesman, Sharon Sacham, Trinayan Kashyap, Boris Klebanov, Romy C. de Vries, Mariah M. Servos, Paul M. Tyler
Selinexor (KPT-330) is a first-in-class nuclear transport inhibitor currently in clinical trials as an anticancer agent. To determine how selinexor might affect antitumor immunity, we analyzed immune homeostasis in mice treated with selinexor and fou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32ca42473c520b40f0072488fdabd409
https://doi.org/10.1158/1535-7163.c.6539275.v1
https://doi.org/10.1158/1535-7163.c.6539275.v1
Autor:
Stephanie K. Dougan, Hidde L. Ploegh, Ulrich H. von Andrian, Quang-De Nguyen, Mohammad Rashidian, Mariah M. Servos, Paul M. Tyler, Olga Blomberg, Novalia Pishesha, Lestat Ali, Patrick T. Bruck, Munir M. Mosaheb, Hee-Jin Jeong, Jessica R. Ingram, Michael Dougan
Cytokine-based therapies for cancer have not achieved widespread clinical success because of inherent toxicities. Treatment for pancreatic cancer is limited by the dense stroma that surrounds tumors and by an immunosuppressive tumor microenvironment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a71fd01468783f14b9fc002e6399036
https://doi.org/10.1158/2326-6066.c.6549281
https://doi.org/10.1158/2326-6066.c.6549281