Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Paul M. Steed"'
Publikováno v:
BioTechniques, Vol 26, Iss 1, Pp 36-42 (1999)
Externí odkaz:
https://doaj.org/article/f4a174056878437ca77fb98aac5ec53d
Autor:
Hanson Gunnar J, Philip F. Hughes, Barta Thomas E, Amy F. Barabasz, Briana Foley, James Marvin Veal, Jeffrey M. Partridge, Christopher John Markworth, Andy J. Ommen, Melanie Silinski, Steven E. Hall, John W. Rice, Paul M. Steed, Emilie D. Smith, Patrick Fadden, Kenneth He Huang, Wei Ma
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:2550-2554
A novel class of Hsp90 inhibitors, structurally distinct from previously reported scaffolds, was developed from rational design and optimization of a compound library screen hit. These aminoquinazoline derivatives, represented by compound 15 (SNX-683
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf7762235091c8d574857ff8ee4a9462
https://doi.org/10.1016/j.bmcl.2012.01.137
https://doi.org/10.1016/j.bmcl.2012.01.137
Autor:
Paul M. Steed, Ken Huang, Tanyel Kiziltepe, Teru Hideshima, Kenneth C. Anderson, Hiroshi Ikeda, John R. Rice, Brianna Foley, Steven E. Hall, Yutaka Okawa, Amy F. Barabasz, Noopur Raje, Hiroshi Yasui, Sotaro Enatsu, Sonia Vallet
Publikováno v:
Blood. 113:846-855
Heat-shock protein 90 (Hsp90) acts as a molecular chaperone required for maintaining the conformational stability of client proteins regulating cell proliferation, survival, and apoptosis. Here we investigate the biologic significance of Hsp90 inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c7ad4a2ee3cbf25ed24d7e36f73b06b
https://doi.org/10.1182/blood-2008-04-151928
https://doi.org/10.1182/blood-2008-04-151928
Autor:
James Marvin Veal, Amy F. Barabasz, Jeffrey M. Partridge, Kenneth He Huang, John W. Rice, Melanie Silinski, Steven E. Hall, Barta Thomas E, Laura G. Dubois, Paul M. Steed, Patrick Fadden, Sarah R. Mabbett
Publikováno v:
Arthritis & Rheumatism. 58:3765-3775
Objective. To evaluate the ability of SNX-7081, a novel small molecule inhibitor of Hsp90, to block components of inflammation, including cytokine production, protein kinase activity, and angiogenic signaling. A close analog was evaluated in preclini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7b5831e5060a3e02003575d5d1ddb12
https://doi.org/10.1002/art.24047
https://doi.org/10.1002/art.24047
Autor:
Paul M. Steed, Larry Norton, Qing Ye, David B. Solit, Neal Rosen, Steven C. Hall, Ayana Sawai, Patrick Fadden, Jeff Partdrige, Ken Huang, Melanie Silinski, Anisa Scott, Sarat Chandarlapaty
Publikováno v:
Clinical Cancer Research. 14:240-248
Purpose: The heat shock protein 90 (Hsp90) chaperone plays an important role in transformation by regulating the conformational maturation and stability of oncogenic kinases and transcription factors. Ansamycins, such as 17-(allylamino)-17-demethoxyg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ae222c2966a7cd5daa4a82845236c02
https://doi.org/10.1158/1078-0432.ccr-07-1667
https://doi.org/10.1158/1078-0432.ccr-07-1667
Autor:
René S Hubert, Paul M Steed
Publikováno v:
Drug Discovery Today. 8:114-117
Highlights of the 9th (Biennial) International Congress on TNF-Related Cytokines (30 October-2 November 2002; The Manchester Grand Hyatt, San Diego, CA, USA.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43dbae9b7ad53108d9c7eaf50d4bee62
https://doi.org/10.1016/s1359-6446(02)02592-8
https://doi.org/10.1016/s1359-6446(02)02592-8
Autor:
Zoltán Kukor, Walter Halangk, Markus M. Lerch, Miklós Sahin-Tóth, Burkhard Krüger, Miklós Tóth, Paul M. Steed, Julia Mayerle
Publikováno v:
Journal of Biological Chemistry. 277:21389-21396
The lysosomal cysteine protease cathepsin B is thought to play a central role in intrapancreatic trypsinogen activation and the onset of experimental pancreatitis. Recent in vitro studies have suggested that this mechanism might be of pathophysiologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2adee68b52245aff833fb8a064a212c5
https://doi.org/10.1074/jbc.m200878200
https://doi.org/10.1074/jbc.m200878200
Publikováno v:
BioTechniques. 26:36-42
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bf9e4617077e47656b96076a3f84394
https://doi.org/10.2144/99261bm05
https://doi.org/10.2144/99261bm05
Publikováno v:
The FASEB Journal. 12:1309-1317
Phospholipase D (PLD) cleaves phosphatidylcholine in response to a variety of cell stimuli to release phosphatidic acid, which is associated with a number of cellular responses including regulated secretion, mitogenesis, and cytoskeletal changes. Rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e953fdc88e11534437b0efb2acb0ee50
https://doi.org/10.1096/fasebj.12.13.1309
https://doi.org/10.1096/fasebj.12.13.1309
Publikováno v:
Protein Science. 7:2033-2037
The lysosomal cysteine protease cathepsin B has been studied intensely for many years because of its unique characteristics and its potential involvement in disease states. A reproducible, high yield expression system for active recombinant protein i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::324dd40d2779becaaa8a300f16543753
https://doi.org/10.1002/pro.5560070920
https://doi.org/10.1002/pro.5560070920