Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Paul M. Stafford"'
Autor:
Kurt R. Stover, Stellar Lim, Terri-Lin Zhou, Paul M. Stafford, Jonathan Chow, Haoyuan Li, Nila Sivanenthiran, Sivakami Mylvaganam, Chiping Wu, Donald F. Weaver, James Eubanks, Liang Zhang
Publikováno v:
IBRO Reports, Vol 3, Iss C, Pp 33-44 (2017)
The incidence of seizures increases with old age. Stroke, dementia and brain tumors are recognized risk factors for new-onset seizures in the aging populations and the incidence of these conditions also increased with age. Whether aging is associated
Externí odkaz:
https://doaj.org/article/c2f5c86ad8ac45fa942ed56c54012e67
Autor:
Emre Fertan, Kurt R.J. Stover, Michael G. Brant, Paul M. Stafford, Brendan Kelly, Elena Diez-Cecilia, Aimée A. Wong, Donald F. Weaver, Richard E. Brown
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
The kynurenine pathway metabolizes tryptophan into nicotinamide adenine dinucleotide, producing a number of intermediary metabolites, including 3-hydroxy kynurenine and quinolinic acid, which are involved in the neurodegenerative mechanisms that unde
Externí odkaz:
https://doaj.org/article/7faa4929d5744b3fbb5ecaceba520d76
Autor:
Elana Raaphorst, Donald F. Weaver, Darapaneni Chandra Mohan, Alexander Kreft, Paolo Schiavini, Jagadeesh P. Pasangulapati, Ramana Reddy Mittapalli, Fan Wu, Laura Villar, Eric C. Keske, Kurt R. Stover, Paul M. Stafford, Kiersten Thomas, Shea L. Johnson, Mark A. Reed, Siva R. Alla, Irina Sagamanova, Mayuri Gupta, Yong Zheng, Simmi Sharma
Publikováno v:
ChemMedChem. 16:2195-2205
Indoleamine 2,3-dioxygenase 1 (IDO1) is a promising therapeutic target in cancer immunotherapy and neurological disease. Thus, searching for highly active inhibitors for use in human cancers is now a focus of widespread research and development effor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::887f2b97155bf3850944d001526b4418
https://doi.org/10.1002/cmdc.202100107
https://doi.org/10.1002/cmdc.202100107
Autor:
Donald F. Weaver, Paolo Schiavini, Michael G. Brant, Fan Wu, Paul M. Stafford, Autumn Meek, Jake Goodwin-tindall, Stephanie Wohnig, Kurt R. Stover
Publikováno v:
ACS Medicinal Chemistry Letters. 9:131-136
Inhibition of indoleamine 2,3-dioxygenase (IDO1) is an attractive immunotherapeutic approach for the treatment of a variety of cancers. Dysregulation of this enzyme has also been implicated in other disorders including Alzheimer’s disease and arthr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::105cf642d362bd217100525060d9594a
https://doi.org/10.1021/acsmedchemlett.7b00488
https://doi.org/10.1021/acsmedchemlett.7b00488
Autor:
Donald F. Weaver, Alexander Kreft, Elana Raaphorst, Darapaneni Chandra Mohan, Yong Zheng, Paolo Schiavini, Paul M. Stafford, Jagadeesh P. Pasangulapati, Kurt R. Stover, Kiersten Thomas, Irina Sagamanova, Laura Villar, Mark A. Reed, Simmi Sharma, Ramana Reddy Mittapalli, Siva R. Alla, Eric C. Keske, Mayuri Gupta, Fan Wu, Shea L. Johnson
Publikováno v:
ChemMedChem. 16:2157-2157
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e87080ef4d741332dd3b33139ab78f7
https://doi.org/10.1002/cmdc.202100466
https://doi.org/10.1002/cmdc.202100466
Autor:
Chiping Wu, Nila Sivanenthiran, Terri-Lin Zhou, Stellar Lim, Donald F. Weaver, Paul M. Stafford, Jonathan Chow, Haoyuan Li, Sivakami Mylvaganam, Kurt R. Stover, James H. Eubanks, Liang Zhang
Publikováno v:
IBRO Reports
IBRO Reports, Vol 3, Iss C, Pp 33-44 (2017)
IBRO Reports, Vol 3, Iss C, Pp 33-44 (2017)
Graphical abstract
Highlights • Hippocampal kindling by daily stimulation conducted in aging and young mice. • Stimulation parameters were comparable in the two groups of mice. • No significant age difference in cumulative afterdischarges
Highlights • Hippocampal kindling by daily stimulation conducted in aging and young mice. • Stimulation parameters were comparable in the two groups of mice. • No significant age difference in cumulative afterdischarges
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80aa7f579ed64cbf76124ac2a1f255e0
http://europepmc.org/articles/PMC6084868
http://europepmc.org/articles/PMC6084868
Publikováno v:
Alzheimer's & Dementia. 14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a09c1b39a82b078b1c3ea17582265f32
https://doi.org/10.1016/j.jalz.2018.06.769
https://doi.org/10.1016/j.jalz.2018.06.769
Autor:
Christopher J. Barden, Michael G. Brant, Mark Reed, Yanfei Wang, Donald F. Weaver, Paul M. Stafford, Marcia Taylor, Elena Cecilia Diez, Brendan Kelly, Autumn Meek
Publikováno v:
Alzheimer's & Dementia. 13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da865451fe8922625d86ce016e123d72
https://doi.org/10.1016/j.jalz.2017.06.1895
https://doi.org/10.1016/j.jalz.2017.06.1895