Výsledky vyhledávání - "Paul M. Radford"

An MltA-Like Lytic Transglycosylase Secreted by Bdellovibrio bacteriovorus Cleaves the Prey Septum during Predatory Invasion

Autor: Emma J. Banks, Carey Lambert, Samuel S. Mason, Jess Tyson, Paul M. Radford, Cameron McLaughlin, Andrew L. Lovering, R. Elizabeth Sockett

Publikováno v: Journal of Bacteriology. 205

Antimicrobial resistance is a serious and rapidly growing threat to global health. Bdellovibrio bacteriovorus can prey upon an extensive range of Gram-negative bacterial pathogens and thus has promising potential as a novel antibacterial therapeutic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::173944013fae4ac2b40877304bad227b
https://doi.org/10.1128/jb.00475-22

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Patients with tumour necrosis factor (TNF) receptor-associated periodic syndrome (TRAPS) are hypersensitive to Toll-like receptor 9 stimulation

Autor: Elizabeth M. McDermott, Ola H. Negm, W Abduljabbar, Patrick J. Tighe, Lucy C. Fairclough, Paul M. Radford, Elizabeth Drewe, Sonali Singh, Mohamed R. Hamed, Ian Todd

Publikováno v: Clin Exp Immunol

Summary Tumour necrosis factor receptor-associated periodic syndrome (TRAPS) is a hereditary autoinflammatory disorder characterized by recurrent episodes of fever and inflammation. It is associated with autosomal dominant mutations in TNFRSF1A, whic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6ea14307a581ff534cb67654460067e
https://doi.org/10.1111/cei.13306

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Engulfment, persistence and fate of Bdellovibrio bacteriovorus predators inside human phagocytic cells informs their future therapeutic potential

Autor: Rob Till, Christopher Gell, Luisa Martinez-Pomares, Sally P. Wheatley, Christopher I. Moore, Patrick J. Tighe, R. Elizabeth Sockett, Jess Tyson, Paul M. Radford, Dhaarini Raghunathan, David Negus

Publikováno v: Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)

In assessing the potential of predatory bacteria, such as Bdellovibrio bacteriovorus, to become live therapeutic agents against bacterial infections, it is crucial to understand and quantify Bdellovibrio host cell interactions at a molecular level. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b99585173de3db078cf8d2e08aa4db3
https://pubmed.ncbi.nlm.nih.gov/30862785

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Tumour necrosis factor receptor I blockade shows that TNF-dependent and TNF-independent mechanisms synergise in TNF receptor associated periodic syndrome

Autor: A. Allart Stoop, Patrick J. Tighe, Ola H. Negm, Paul M. Radford, Ian Todd, Lucy C. Fairclough

Publikováno v: European Journal of Immunology. 45:2937-2944

TNF receptor associated periodic syndrome (TRAPS) is an autoinflammatory disease involving recurrent episodes of fever and inflammation. It is associated with autosomal dominant mutations in TNF receptor superfamily 1A gene localised to exons encodin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f25e438a450be677f3695374a2fc505
https://doi.org/10.1002/eji.201545769

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Measuring and modelling the response of Klebsiella pneumoniae KPC prey to Bdellovibrio bacteriovorus predation, in human serum and defined buffer

Autor: Paul M. Radford, R. Elizabeth Sockett, Jamie Twycross, Mathew Diggle, Gemma Clark, David Negus, Christopher I. Moore, Dhaarini Raghunathan, Michelle Baker, Jess Tyson

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-18 (2017)
Scientific Reports

In worldwide conditions of increasingly antibiotic-resistant hospital infections, it is important to research alternative therapies. Bdellovibrio bacteriovorus bacteria naturally prey on Gram-negative pathogens, including antibiotic-resistant strains

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c1b0cc9d983cf00200db5b23d168ed9
https://igi.indrastra.com/items/show/19751

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Novel markers of inflammation identified in tumor necrosis factor receptor-associated periodic syndrome (TRAPS) by transcriptomic analysis of effects of TRAPS-associated tumor necrosis factor receptor type I mutations in an endothelial cell line

Autor: Roel Fiets, Paul M. Radford, Mohammad R. Amel-Kashipaz, Ian Todd, Susana L. Rebelo, Susan E. Bainbridge, Richard J. Powell, Patrick J. Tighe, Johnny Fang, Elizabeth M. McDermott

Publikováno v: Arthritis & Rheumatism. 60:269-280

Objective To analyze the effects of tumor necrosis factor receptor–associated periodic syndrome (TRAPS)–associated mutant tumor necrosis factor receptor type I (TNFRI) expression in a cell type directly relevant to the inflammation in TRAPS, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d09dff7a4c29f68569c2fd40fee6440
https://doi.org/10.1002/art.24147

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Mutant tumor necrosis factor receptor associated with tumor necrosis factor receptor–associated periodic syndrome is altered antigenically and is retained within patients' leukocytes

Autor: Paul M. Radford, Susan E. Bainbridge, Patrick J. Tighe, Richard J. Powell, Ian Todd, Noura Daffa

Publikováno v: Arthritis & Rheumatism. 56:2765-2773

Objective To investigate the effect of mutations in tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) in TNFR-associated periodic syndrome (TRAPS) on the binding of anti-TNFRSF1A monoclonal antibodies (mAb), and to investigate the subce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf998783c2617fe0d005cf3501153e86
https://doi.org/10.1002/art.22740

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Modeling of tumor necrosis factor receptor superfamily 1A mutants associated with tumor necrosis factor receptor–associated periodic syndrome indicates misfolding consistent with abnormal function

Autor: Paul M. Radford, Susana L. Rebelo, Richard J. Powell, Mohammad R. Amel-Kashipaz, Susan E. Bainbridge, Ian Todd, Patrick J. Tighe

Publikováno v: Arthritis & Rheumatism. 54:2674-2687

Objective To investigate the effect of mutations in the tumor necrosis factor receptor superfamily 1A (TNFRSF1A) gene on the conformation and behavior of the TNFRSF1A protein. Mutations in TNFRSF1A cause the autosomal-dominant, autoinflammatory TNFR-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::364dfcf3650f6d3b5e1a5e90ef4b151c
https://doi.org/10.1002/art.21964

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Shedding of mutant tumor necrosis factor receptor superfamily 1A associated with tumor necrosis factor receptor-associated periodic syndrome: Differences between cell types

Autor: Richard S. McIntosh, Paul M. Radford, Kelly‐Ann Draper‐Morgan, Richard J. Powell, Mary L. Huggins, Peter Dickinson, Patrick J. Tighe, Susan E. Bainbridge, Ian Todd

Publikováno v: Arthritis & Rheumatism. 50:2651-2659

Objective To investigate the effect of mutations in tumor necrosis factor receptor superfamily 1A (TNFRSF1A) on the ability of the receptors to be cleaved from the cell surface upon stimulation. The mutations we studied are associated with clinically

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a7ad7132b98d18c0393f3931ed879e3
https://doi.org/10.1002/art.20380

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