Zobrazeno 1 - 10 of 100 pro vyhledávání: '"Paul M. O'Connor"'
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Akademický článek
Differential release of extracellular vesicle tRNA from oxidative stressed renal cells and ischemic kidneys
Autor: Hee Kyung Lee, Byung Rho Lee, Tae Jin Lee, Chang Min Lee, Chenglong Li, Paul M. O’Connor, Zheng Dong, Sang-Ho Kwon
Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract While urine-based liquid biopsy has expanded to the analyses of extracellular nucleic acids, the potential of transfer RNA (tRNA) encapsulated within extracellular vesicles has not been explored as a new class of urine biomarkers for kidney
Externí odkaz: https://doaj.org/article/31c6a5518e03482490f9c1a0c4802e81
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2
Akademický článek
Voltage gated proton channels modulate mitochondrial reactive oxygen species production by complex I in renal medullary thick ascending limb
Autor: Bansari Patel, Nadezhda N. Zheleznova, Sarah C. Ray, Jingping Sun, Allen W. Cowley, Jr., Paul M. O'Connor
Publikováno v: Redox Biology, Vol 27, Iss , Pp - (2019)
Hv1 is a voltage-gated proton channel highly expressed in immune cells where, it acts to maintain NAD(P)H oxidase activity during the respiratory burst. We have recently reported that Hv1 is expressed in cells of the medullary thick ascending limb (m
Externí odkaz: https://doaj.org/article/fddb682b8d384971ba078acfc9423946
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3
New mechanisms for the kidney-protective effect of alkali in chronic kidney disease
Autor: Paul M, O'Connor, Elinor C, Mannon
Publikováno v: Clinical Science. 136:1433-1437
Worldwide, more than one in ten adults are estimated to have chronic kidney disease (CKD). As CKD progresses, both the cost of treatment and associated risk of morbidity and mortality increase exponentially. As such, there is a great need for therapi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42e01a46053ec197fa6a6a0e0b14da7b
https://doi.org/10.1042/cs20220395
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4
Hidden in Plain Sight: Does Medullary Red Blood Cell Congestion Provide the Explanation for Ischemic Acute Kidney Injury?
Autor: Sarah C. McLarnon, Chloe Johnson, Priya Giddens, Paul M. O'Connor
Publikováno v: Seminars in nephrology. 42(3)
Acute kidney injury (AKI) represents a sudden reduction in renal function and is a major clinical problem with a high mortality rate. Despite decades of research, there are currently no direct therapies for AKI. The failure of therapeutic approaches
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4b043533413acdba06dcd1432d64373
https://pubmed.ncbi.nlm.nih.gov/36460572
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5
Renal mass reduction increases the response to exogenous insulin independent of acid-base status or plasma insulin levels in rats
Autor: Trevin C Wilkes, Jingping Sun, Christina L Sartain, Aaron J. Polichnowski, Paul M. O'Connor, Elinor C. Mannon
Publikováno v: Am J Physiol Renal Physiol
Impairments in insulin sensitivity can occur in patients with chronic kidney disease (CKD). Correction of metabolic acidosis has been associated with improved insulin sensitivity in CKD, suggesting that metabolic acidosis may directly promote insulin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::815c745e11c320ca7fb0ad6a8897328d
https://doi.org/10.1152/ajprenal.00679.2020
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8
Ultrasound measurement of change in kidney volume is a sensitive indicator of severity of renal parenchymal injury
Autor: Paul M. O'Connor, Bansari Patel, Sarah C. Ray, Qingqing Wei, Jingping Sun, G. Ryan Crislip, Aaron J. Polichnowski, Jennifer C. Sullivan, Riyaz Mohamed
Publikováno v: Am J Physiol Renal Physiol
Noninvasive determination of the severity of parenchymal injury in acute kidney injury remains challenging. Edema is an early pathological process following injury, which may correlate with changes in kidney volume. The goal of the present study was
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c88e74cd603cb1a286d45d9ea2d0403
https://doi.org/10.1152/ajprenal.00221.2020
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9
Persistent vascular congestion in male spontaneously hypertensive rats contributes to delayed recovery of renal function following renal ischemia perfusion compared with females
Autor: Riyaz Mohamed, Gene R. Crislip, Sarah McLarnon, Qingqing Wei, Paul M. O’Connor, Jennifer C. Sullivan
Publikováno v: Clinical science (London, England : 1979). 136(11)
Acute kidney injury (AKI) due to ischemia is a serious and frequent clinical complication with mortality rates as high as 80%. Vascular congestion in the renal outer medulla occurs early after ischemia reperfusion (IR) injury, and congestion has been
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c7dbe5c6cc6fe149e87ade7a63a1f45
https://pubmed.ncbi.nlm.nih.gov/35535709
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10
Ischemic Renal Injury: Can Renal Anatomy and Associated Vascular Congestion Explain Why the Medulla and Not the Cortex Is Where the Trouble Starts?
Autor: Paul M. O'Connor, Sarah C. Ray, June Mason
Publikováno v: Seminars in Nephrology. 39:520-529
The kidneys receive approximately 20% of cardiac output and have a low fractional oxygen extraction. Quite paradoxically, however, the kidneys are highly susceptible to ischemic injury (injury associated with inadequate blood supply), which is most e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::869cb3b0d31bf26167e54f8678dc5afd
https://doi.org/10.1016/j.semnephrol.2019.10.002
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