Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Paul M. Loewenstein"'
Publikováno v:
Virology. 499:178-184
The adenovirus E1A 243R oncoprotein targets TRRAP, a scaffold protein that assembles histone acetyltransferase (HAT) complexes, such as the NuA4/Tip60 complex which mediates transcriptional activity of the proto-oncogene MYC and helps determine the c
Publikováno v:
Genes & Cancer
Human cancers frequently arise from increased expression of proto-oncogenes, such as MYC and HER2. Understanding the cellular pathways regulating the transcription and expression of proto-oncogenes is important for targeted therapies for cancer treat
Publikováno v:
Genes & Cancer
We recently reported that adenovirus E1A enhances MYC association with the NuA4/Tip60 histone acetyltransferase (HAT) complex to activate a panel of genes enriched for DNA replication and cell cycle. Genes from this panel are highly expressed in exam
Publikováno v:
Genes & Cancer
The proto-oncogene MYC is a transcription factor over-expressed in many cancers and required for cell survival. Its function is regulated by histone acetyltransferase (HAT) complexes, such as the GCN5 complex and the NuA4/Tip60 complex. However, the
Publikováno v:
Genes & Cancer
Expression of the adenovirus E1A N-terminal transcription repression domain alone (E1A 1-80) represses transcription from specific promoters such as HER2 [1] and from reconstituted chromatin [2]. Significantly, E1A 1-80 can induce the death of human
Cellular transformation by adenovirus E1A requires targeting TRRAP, a scaffold protein which helps assemble histone acetyltransferase complexes, including the NuA4 complex. We recently reported that E1A and E1A 1-80 (N-terminal 80 aa) promote associa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68884cf2e0f031b380a5c2de1d45481e
https://europepmc.org/articles/PMC5790114/
https://europepmc.org/articles/PMC5790114/
Publikováno v:
Virology. 515:261-262
Publikováno v:
Oncogene. 27:4446-4455
Extensive mutational/functional analysis of the transcription-repression domain encoded in the N-terminal 80 amino acids of the adenovirus E1A 243R oncoprotein suggests a model for the molecular mechanism of E1A repression: E1A accesses transcription
Publikováno v:
Virology. 351:312-321
Adenovirus early gene 1A (E1A) possesses a potent transcriptional repression function within the first 80 amino acids (E1A 1–80). Our previous analysis of subdomain 1 (residues 1 to 30) revealed strong correlations between residues required for rep
Autor:
Chao-Zhong Song, Maurice Green, Paul M. Loewenstein, Karoly Toth, Qing-quan Tang, A Nishikawa
Publikováno v:
Molecular and Cellular Biology. 17:2186-2193
The human adenovirus E1A 243 amino acid oncoprotein possesses a transcription repression function that appears to be linked with its ability to induce cell cycle progression and to inhibit cell differentiation. The molecular mechanism of E1A repressi