Zobrazeno 1 - 10
of 186
pro vyhledávání: '"Paul M. Loadman"'
Autor:
Francis M. Barnieh, Goreti Ribeiro Morais, Paul M. Loadman, Robert A. Falconer, Sherif F. El‐Khamisy
Publikováno v:
Advanced Science, Vol 11, Iss 34, Pp n/a-n/a (2024)
Abstract Targeted therapy remains the future of anti‐cancer drug development, owing to the lack of specificity of current treatments which lead to damage in healthy normal tissues. ATR inhibitors have in recent times demonstrated promising clinical
Externí odkaz:
https://doaj.org/article/89b2cd1dff6344aabd813f0ac8032b72
Autor:
Francis M. Barnieh, Sebastian P. Galuska, Paul M. Loadman, Simon Ward, Robert A. Falconer, Sherif F. El-Khamisy
Publikováno v:
iScience, Vol 26, Iss 11, Pp 108219- (2023)
Summary: Harnessing the differences between cancer and non-cancer tissues presents new opportunities for selective targeting by anti-cancer drugs. CD13, a heavily glycosylated protein, is one example with significant unmet clinical potential in cance
Externí odkaz:
https://doaj.org/article/bd2bf1908dae46818c9cada538aeea92
Autor:
Nicola Ingram, Radwa H. Abou-Saleh, Amanda D. Race, Paul M. Loadman, Richard J. Bushby, Stephen D. Evans, P. Louise Coletta
Publikováno v:
Pharmaceutics, Vol 16, Iss 3, p 434 (2024)
Therapeutic microbubbles (thMBs) contain drug-filled liposomes linked to microbubbles and targeted to vascular proteins. Upon the application of a destructive ultrasound trigger, drug uptake to tumour is improved. However, the structure of thMBs curr
Externí odkaz:
https://doaj.org/article/abff952cecfb4e338f01079ea86da640
Autor:
Daniela Presa, Syed A. Khurram, Amir Z. A. Zubir, Sneha Smarakan, Patricia A. Cooper, Goreti R. Morais, Maria Sadiq, Mark Sutherland, Paul M. Loadman, James McCaul, Steven D. Shnyder, Laurence H. Patterson, Klaus Pors
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Epidemiological studies have shown that head and neck cancer (HNC) is a complex multistage process that in part involves exposure to a combination of carcinogens and the capacity of certain drug-metabolising enzymes including cytochrome P450
Externí odkaz:
https://doaj.org/article/4ea9b86b01fd4ec18d301c0d665c1e69
Publikováno v:
Current Research in Pharmacology and Drug Discovery, Vol 2, Iss , Pp 100017- (2021)
The DNA damage response (DDR) is now known to play an important role in both cancer development and its treatment. Targeting proteins such as ATR (Ataxia telangiectasia mutated and Rad3-related) kinase, a major regulator of DDR, has demonstrated sign
Externí odkaz:
https://doaj.org/article/119315a7ae774e0fb0ba04253dc5fc6e
Autor:
Nicola Ingram, Laura E. McVeigh, Radwa H. Abou-Saleh, Damien V. B. Batchelor, Paul M. Loadman, James R. McLaughlan, Alexander F. Markham, Stephen D. Evans, P. Louise Coletta
Publikováno v:
Pharmaceutics, Vol 14, Iss 3, p 622 (2022)
Advanced drug delivery systems, such as ultrasound-mediated drug delivery, show great promise for increasing the therapeutic index. Improvements in delivery by altering the ultrasound parameters have been studied heavily in vitro but relatively littl
Externí odkaz:
https://doaj.org/article/102e52c5286745469f1868078ad550f9
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 12, Iss 8, Pp 618-627 (2010)
The ω-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA), in the free fatty acid (FFA) form, has been demonstrated to reduce adenoma number and size in patients with familial adenomatous polyposis. However, the mechanistic basis of the antineo
Externí odkaz:
https://doaj.org/article/be6fa3ad9e28459f8f163e30ae849457
Autor:
Jason H. Gill, Ian G. Kirwan, Jill M. Seargent, Sandie W. Martin, Sidiq Tijani, Vladimir A. Anikin, Alan J. Mearns, Michael C. Bibby, Alan Anthoney, Paul M. Loadman
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 6, Iss 6, Pp 777-785 (2004)
Matrix metalloproteinase (MMP)-mediated degradation of the extracellular matrix is a major factor for tumor development and expansion. This study analysed MMP-10 protein expression and activity in human lung tumors of various grade, stage, and type t
Externí odkaz:
https://doaj.org/article/e0ffa739011f499180f18e6b04e24d94
Autor:
Heike E. Daldrup-Link, Robert A. Falconer, Paul M. Loadman, Jianghong Rao, Sanjiv Sam Gambhir, Edwin Chang, Samuel Cheshier, Siddharta Mitra, Frederick T. Chin, Laura Pisani, Ketan Yerneni, Jessica Klockow, Goreti Ribeiro Morais, Kai Li, Zixin Chen, Suchismita Mohanty
Glioblastoma (GBM) has a dismal prognosis. Evidence from preclinical tumor models and human trials indicates the role of GBM-initiating cells (GIC) in GBM drug resistance. Here, we propose a new treatment option with tumor enzyme-activatable, combine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6cfde44f0d5475ce85a61715b8ac14d
https://doi.org/10.1158/1535-7163.c.6539568.v1
https://doi.org/10.1158/1535-7163.c.6539568.v1
Autor:
Laurence H. Patterson, Steve D. Shnyder, Klaus Pors, Mark Searcey, Patricia A. Cooper, Mohammed N. Alandas, Nicola A. Illingworth, Helen M. Sheldrake, Jonathan P. Laye, Paul M. Loadman, Jason H. Gill, Mark Sutherland
PDF file - 107K, In vivo metabolic profile of tumour and liver after administration of ICT2700 to CYP1A1 tumor-bearing mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53fa7a3eeadf697425f73382b1b2ff93
https://doi.org/10.1158/1535-7163.22499368.v1
https://doi.org/10.1158/1535-7163.22499368.v1