Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Paul M. Kraemer"'
When tumorigenic cultured cell populations are inoculated into nude mice, the tumorigenic process generally requires further progression and selection in vivo. This in vivo progression should be reflected in the altered properties of the tumor cells,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c8d4526e007010a6865305dad2cca66
https://doi.org/10.1159/000413316
https://doi.org/10.1159/000413316
Autor:
George C. Saunders, F. Andrew Ray, Anita P. Stevenson, Paul M. Kraemer, Gayle L. Travis, Karen Bame, L. Scott Cram
Gelatin sponges, preimplanted in nude mice for 10 days, were used for an improved assay for tumorigenicity of cultured cells. Cells inoculated through the skin into such sponges yielded tumors more rapidly and with greater frequency than with newly i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::581497cf76dc739694495adeadd0156b
https://doi.org/10.1159/000408620
https://doi.org/10.1159/000408620
Autor:
Jac A. Nickoloff, John B. Little, John M. Lehman, Mary Jo Waltman, F. Andrew Ray, Paul M. Kraemer
Publikováno v:
Cytometry. 31:242-250
The SV40 T antigen causes numerical (aneuploidy) and structural (aberrations) chromosome damage when expressed in human diploid fibroblasts. This chromosome damage precedes the acquisition of neoplastic traits such as anchorage independence, colony f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba88fa9c7193d5f0a94c7e919dc1a30a
https://doi.org/10.1002/(sici)1097-0320(19980401)31:4<242::aid-cyto3>3.0.co
https://doi.org/10.1002/(sici)1097-0320(19980401)31:4<242::aid-cyto3>3.0.co
Autor:
Paul M. Kraemer, F. Andrew Ray
Publikováno v:
Carcinogenesis. 14:1511-1516
The acquisition of an extended lifespan and of neoplastic properties, including anchorage independence, ability to grow in low serum-containing media, morphological transformation, immortalization and tumorigenicity in nude mice were studied in 31 hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36aa522ea3f057a337573b710ad34fdc
https://doi.org/10.1093/carcin/14.8.1511
https://doi.org/10.1093/carcin/14.8.1511
Autor:
John E. Wiley, Marty F. Bartholdi, Paul M. Kraemer, Charles L. Goolsby, Marianne Steiner, L. Scott Cram
Publikováno v:
Cancer Genetics and Cytogenetics. 50:231-248
Normal human foreskin fibroblasts (HSF4) were transfected using the pSV3-neo plasmid. A pool of 10 G418-resistant colonies, HSF4-T12, showed a progressive increase in the expression of a number of in vitro transformation markers with passage in cultu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f33da70cc4f12875f5739fb1983d2806
https://doi.org/10.1016/0165-4608(90)90183-b
https://doi.org/10.1016/0165-4608(90)90183-b
Publikováno v:
Journal of Cellular Biochemistry. 42:13-31
To define the role of SV40 large T antigen in the transformation and immortalization of human cells, we have constructed a plasmid lacking most of the unique coding sequences of small t antigen as well as the SV40 origin of replication. The promoter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f693a6d54c420e6d9e02961f989ac5d
https://doi.org/10.1002/jcb.240420103
https://doi.org/10.1002/jcb.240420103
Autor:
Paul M. Kraemer, Bradbury Em
Publikováno v:
Experimental cell research. 207(1)
Cell cycle arrest points that are sensitive to the kinase inhibitor staurosporine have been shown to have widely differing sensitivities for processes in G1 and G2. In addition, the exquisitely sensitive G1 arrest point has been reported to be abroga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4524bc463bb280616672541d6a099f3
https://pubmed.ncbi.nlm.nih.gov/8391466
https://pubmed.ncbi.nlm.nih.gov/8391466
Publikováno v:
Mutation research. 284(2)
In human fibroblasts, the expression of SV40 large T antigen is known to cause a variety of chromosomal aberrations and especially dicentric chromosomes. In some cases, the later aberrations have been reported to be reversible telomeric associations.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d59b3a1263c9b6f6279e8997c2d52fe
https://pubmed.ncbi.nlm.nih.gov/1281278
https://pubmed.ncbi.nlm.nih.gov/1281278
Autor:
Paul M. Kraemer, F. Andrew Ray
Publikováno v:
Cancer genetics and cytogenetics. 59(1)
Nine newly immortal lines of human fibroblasts transfected with SV40 T antigen were examined for recurrent chromosome losses. In order of decreasing frequency, all nine lines had three or more of the following minimal deletions specifically associate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc559435f50ab66a686603854fda1fae
https://pubmed.ncbi.nlm.nih.gov/1313331
https://pubmed.ncbi.nlm.nih.gov/1313331
Autor:
Jonathan L. Longmire, Paul M. Kraemer, Raymond L. Stallings, E.W. Campbell, Judith G. Tesmer, D. Chen
Publikováno v:
Cancer genetics and cytogenetics. 48(1)
The hypothesis that trans-acting factors affect chromosome stability was explored using human X Chinese hamster somatic cell hybrids. Two types of hybrids were examined. In either case, the human parent consisted of human diploid fibroblasts, the chr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc6154c025d7d814d872208b9b7624f8
https://pubmed.ncbi.nlm.nih.gov/2164880
https://pubmed.ncbi.nlm.nih.gov/2164880