Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Paul M. Holloway"'
Autor:
Elizabeth B. Klerman, Allison Brager, Mary A. Carskadon, Christopher M. Depner, Russell Foster, Namni Goel, Mary Harrington, Paul M. Holloway, Melissa P. Knauert, Monique K. LeBourgeois, Jonathan Lipton, Martha Merrow, Sara Montagnese, Mingming Ning, David Ray, Frank A. J. L. Scheer, Steven A. Shea, Debra J. Skene, Claudia Spies, Bart Staels, Marie‐Pierre St‐Onge, Steffen Tiedt, Phyllis C. Zee, Helen J. Burgess
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 12, Pp n/a-n/a (2022)
Abstract Background Daily rhythms are observed in humans and almost all other organisms. Most of these observed rhythms reflect both underlying endogenous circadian rhythms and evoked responses from behaviours such as sleep/wake, eating/fasting, rest
Externí odkaz:
https://doaj.org/article/d90a40d7fa534e5a8d6e5ee138971957
Autor:
Jakob Walther, Elena Marie Kirsch, Lina Hellwig, Sarah S. Schmerbeck, Paul M. Holloway, Alastair M. Buchan, Philipp Mergenthaler
Publikováno v:
Translational Stroke Research.
The concept of the ischemic penumbra was originally defined as the area around a necrotic stroke core and seen as the tissue at imminent risk of further damage. Today, the penumbra is generally considered as time-sensitive hypoperfused brain tissue w
Autor:
Paul M, Holloway
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2492
The use of microfluidic chips is now allowing for more advanced modelling of the blood-brain barrier (BBB) in vitro, recapitulating heterotypic interactions, 3D architecture, and physiological flow. This chapter will give an introduction to these new
Autor:
Paul M. Holloway
Publikováno v:
Methods in Molecular Biology ISBN: 9781071622889
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b07444e7ca096b303d0dc223575f7f6
https://doi.org/10.1007/978-1-0716-2289-6_11
https://doi.org/10.1007/978-1-0716-2289-6_11
Autor:
Simon I. R. Lane, Maaike S. A. Jongen, Owen J. T. McCarty, Jonathan West, Nicola A. Englyst, Paul M. Holloway
Publikováno v:
Cell Mol Bioeng
Introduction: Precision mapping of the functional structure of platelet populations holds great promise for the identification of hyper-reactive subtypes that are likely to be disease drivers, having value in prognostics and as therapeutic targets. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cada9b484f709cd898b73c23fe8942c4
https://eprints.soton.ac.uk/446770/
https://eprints.soton.ac.uk/446770/
Autor:
Melissa Barber, Eric J. Hill, Richard C.M. Siow, Sandrine Willaime-Morawek, Michele Zagnoni, Wendy Rowan, Anup D. Sharma, Róisín M. Owens, Paul M. Holloway
Neurological disorders are the leading cause of disability and the second largest cause of death worldwide. Despite significant research efforts, neurology remains one of the most failure-prone areas of drug development. The complexity of the human b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d04883373f665d6d4c5fd6cb72950f0
https://strathprints.strath.ac.uk/75778/1/Holloway_etal_JNR_2021_Advances_in_microfluidic_in_vitro_systems_for_neurological_disease_modeling.pdf
https://strathprints.strath.ac.uk/75778/1/Holloway_etal_JNR_2021_Advances_in_microfluidic_in_vitro_systems_for_neurological_disease_modeling.pdf
Autor:
Nicola A. Englyst, James S. Wilkinson, Jonathan West, Paul M. Holloway, Peter Horak, Jonathan Butement, Judith A. Holloway, Joshua A. Welsh
Publikováno v:
Lab on a chip. 20(7)
Size measurement of extracellular vesicles is hampered by the high cost and measurement uncertainty of conventional flow cytometers which is mainly due to the use of non-specialised free space optics. Integrated cytometry, where the optics and fluidi
Autor:
Francesca Rauzi, Paul M. Holloway, Scarlett Gillespie, Kirk A. Taylor, Karen Y. Stokes, Felicity N. E. Gavins, Felix Becker, Shantel Vital, Michael Emerson
Publikováno v:
British Journal of Pharmacology. 175:3333-3346
Background and purpose Platelet activation provides a critical link between inflammation and thrombosis. Sulforaphane (SFN), a naturally occurring isothiocyanate, has been shown to display both anti-inflammatory and anti-thrombotic actions in the sys
Autor:
Paul M. Holloway, Katrin Deinhardt, Manjunath Hegde, Grace I. Hallinan, Jonathan West, Lane Sir.
Publikováno v:
Lab on a chip. 19(8)
Directional connectivity is required to develop accurate in vitro models of the nervous system. This research investigated the interaction of murine neuronal outgrowths with asymmetric microstructured geometries to provide insights into the mechanism
Autor:
Felix Becker, Paul M. Holloway, Scarlett Gillespie, Nguyen, Shantel Vital, Paul C. Evans, Fne Gavins, Jonathan Steven Alexander
Publikováno v:
Vascular Pharmacology. 85:29-38
Sepsis is often characterized by an acute brain inflammation and dysfunction, which is associated with increased morbidity and mortality worldwide. Preventing cerebral leukocyte recruitment may provide the key to halt progression of systemic inflamma