Zobrazeno 1 - 10 of 21 pro vyhledávání: '"Paul M. Hext"'
1
Analysis of biomarkers in rats and dogs exposed to polymeric methylenediphenyl diisocyanate (pMDI) and its glutathione adduct
Autor: Gabriele Leng, William E. Brown, Edgar Leibold, Jürgen Pauluhn, Paul M. Hext
Publikováno v: Toxicology. 222:202-212
Hemoglobin adducts (Hb-MDX) of monomeric methylenediphenyl diisocyanate (MDI) are often interpreted as indirect evidence of hydrolysis of the diisocyanate moiety to the respective amine (diphenylmethane-4,4'-diamine, 4,4'-MDA) which constitutes the r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcd50fbaa6462a3f8216cc9106d89df5
https://doi.org/10.1016/j.tox.2006.02.014
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2
Long-Term Pulmonary Responses of Three Laboratory Rodent Species to Subchronic Inhalation of Pigmentary Titanium Dioxide Particles
Autor: Edward E. Reverdy, Paul M. Hext, Brian A. Wong, James B. Mangum, David B. Warheit, Bahman Asgharian, Derek B. Janszen, Jeffrey I. Everitt, Edilberto Bermudez
Publikováno v: Toxicological Sciences. 70:86-97
Female mice, rats, and hamsters were exposed to 10, 50, or 250 mg/m 3 pigmentary titanium dioxide (p-TiO 2 ) particles for 6 h per day and 5 days per week for 13 weeks with recovery groups held for an additional 4, 13, 26, or 52 weeks postexposure (4
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bef60d13df2bfd95b443a9a9bb844bbd
https://doi.org/10.1093/toxsci/70.1.86
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3
Responses in the respiratory tract of rats following exposure to sulphuric acid aerosols for 5 or 28 days
Autor: John R. Foster, Joanne D. Kilgour, Paul M. Hext, Anthony R. Soames, David G. Farrar
Publikováno v: Journal of Applied Toxicology. 22:387-395
Sulphuric acid mists have been classified by the International Agency for Research on Cancer as being carcinogenic to humans based on epidemiological findings of respiratory tract tumours. To determine if early changes in the respiratory tract follow
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::144fdc09e1eebac072eefb73539125e9
https://doi.org/10.1002/jat.875
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4
Formic acid excretion in rats exposed to trichloroethylene: a possible explanation for renal toxicity in long-term studies
Autor: Paul M. Hext, Trevor Green, John R. Foster, Jacky Dow
Publikováno v: Toxicology. 127:39-47
Rats exposed to trichloroethylene, either by gavage or by inhalation, excreted large amounts of formic acid in urine which was accompanied by a change in urinary pH, increased excretion of ammonia, and slight increases in the excretion of calcium. Fo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc40b9206f96e02c9fd4e982e371376f
https://doi.org/10.1016/s0300-483x(98)00020-1
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6
The Inhalation Toxicology, Genetic Toxicology, and Metabolism of Difluoromethane in the Rat
Autor: Kathryn Tseung, Trevor Green, Jacky L. Naylor, Michael A. Collins, Paul M. Hext, Richard Trebilcock, Martin K. Ellis
Publikováno v: Toxicological Sciences. 31:243-251
Difluoromethane (HFC32) is under development as a replacement for chlorofluorocarbons (CFCs) in some refrigeration applications. It has been evaluated by standard studies of toxicity, developmental toxicity, and genotoxicity. In addition, the metabol
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a6c8f14f55629c24f7d38bf97dce404
https://doi.org/10.1093/toxsci/31.2.243
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8
Titanium Dioxide: Inhalation Toxicology and Epidemiology
Autor: Peter Thompson, John A. Tomenson, Paul M. Hext
Publikováno v: The Annals of Occupational Hygiene.
Titanium dioxide (TiO(2)) is manufactured worldwide in large quantities for use in a wide range of applications and is normally considered to be toxicologically inert. Findings of tumours in the lungs of rats exposed chronically to high concentration
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::662045f19df291361c8b86d0b38936a6
https://doi.org/10.1093/annhyg/mei012
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9
Pulmonary responses of mice, rats, and hamsters to subchronic inhalation of ultrafine titanium dioxide particles
Autor: Edilberto Bermudez, James B. Mangum, David B. Warheit, Brian A. Wong, Bahman Asgharian, Jeffrey I. Everitt, Paul M. Hext
Publikováno v: Toxicological sciences : an official journal of the Society of Toxicology. 77(2)
A multispecies, subchronic, inhalation study comparing pulmonary responses to ultrafine titanium dioxide (uf-TiO(2)) was performed. Female rats, mice, and hamsters were exposed to aerosol concentrations of 0.5, 2.0, or 10 mg/m(3) uf-TiO(2) particles
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0992d89e650d99637ca4d074cf176d4e
https://pubmed.ncbi.nlm.nih.gov/14600271
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10
Comparison of the Pulmonary Responses to Inhaled Pigmentary and Ultrafine Titanium Dioxide Particles in the Rat, Mouse and Hamster
Autor: J. Mangum, Jeffrey I. Everitt, Brian A. Wong, Bahman Asgharian, Paul M. Hext, E. Bermudez, David B. Warheit
Publikováno v: The Annals of Occupational Hygiene.
Groups of female rats, mice and hamsters were exposed to 10, 50 or 250 mg/m3 pigment grade titanium dioxide (PG-TiO 2 ) or to 0.5, 2 or 10 mg/m3 ultrafine titanium dioxide (UF-TiO 2 ) for 6 h/day, 5 days/week for 13 weeks. At the end of the exposure
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2b5c314a1e847133b366d70d7aeea781
https://doi.org/10.1093/annhyg/46.suppl_1.191
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