Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Paul M. Hershberger"'
Autor:
Paul M. Hershberger, Satyamaheshwar Peddibhotla, E. Hampton Sessions, Daniela B. Divlianska, Ricardo G. Correa, Anthony B. Pinkerton, John C. Reed, Gregory P. Roth
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 9, Iss 1, Pp 900-907 (2013)
Activation of nuclear factor-kappa B (NF-κB) and related upstream signal transduction pathways have long been associated with the pathogenesis of a variety of inflammatory diseases and has recently been implicated in the onset of cancer. This report
Externí odkaz:
https://doaj.org/article/789311d353004329b484f281ae36bb75
Autor:
Aiste Dobrovolskaite, Holly Moots, Mukund P. Tantak, Kunal Shah, Jenna Thomas, Sharifa Dinara, Chelsea Massaro, Paul M. Hershberger, Patrick R. Maloney, Satyamaheshwar Peddibhotla, Eliot Sugarman, Sally Litherland, Juan Pablo Arnoletti, Rajiv Kumar Jha, David Levens, Otto Phanstiel
Publikováno v:
Journal of medicinal chemistry. 65(22)
Polyamine biosynthesis is regulated by ornithine decarboxylase (ODC), which is transcriptionally activated by c-Myc. A large library was screened to find molecules that potentiate the ODC inhibitor, difluoromethylornithine (DFMO). Anthranilic acid de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5048172ae7721fd307b0c1dc01dcba9b
https://pubmed.ncbi.nlm.nih.gov/36382923
https://pubmed.ncbi.nlm.nih.gov/36382923
Autor:
S. Jeson Sangaralingham, Kanupriya Whig, Satyamaheshwar Peddibhotla, R. Jason Kirby, Hampton E. Sessions, Patrick R. Maloney, Paul M. Hershberger, Heather Mose-Yates, Becky L. Hood, Stefan Vasile, Shuchong Pan, Ye Zheng, Siobhan Malany, John C. Burnett
Publikováno v:
Proc Natl Acad Sci U S A
The particulate guanylyl cyclase A receptor (GC-A), via activation by its endogenous ligands atrial natriuretic peptide (ANP) and b-type natriuretic peptide (BNP), possesses beneficial biological properties such as blood pressure regulation, natriure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c477634b8ff7b61af02aff22ec6e795
https://pubmed.ncbi.nlm.nih.gov/34930837
https://pubmed.ncbi.nlm.nih.gov/34930837
Autor:
Timothy W. Morris, Michael C. Davis, Paul J. Renick, Shari S. Soper, A. Greg Switzer, David Robert Jones, Shyam Sunder, Christian N. Parker, Qimin Wu, Mark Edward Stella, Paul M. Hershberger, Lawrence J. Wilson, Helana D. McKeever, Gary Paul Shrum, Thomas M Burt, Kenneth L. Morand, Roy L. M. Dobson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:1149-1152
An effort to identify novel inhibitors of peptidoglycan synthesis with antibacterial activity resulted in the discovery of a series of biaryl urea-based antibacterial agents through isolation of a by-product from a mixture-based combinatorial library
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5f81ce84d0aafb593d2a8b073aeb1c6
https://doi.org/10.1016/s0960-894x(01)00160-3
https://doi.org/10.1016/s0960-894x(01)00160-3
Autor:
Paul M. Hershberger, ET AL. ET AL.
Publikováno v:
ChemInform. 30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d22245abd5225494ebaa5ea6683966cf
https://doi.org/10.1002/chin.199910258
https://doi.org/10.1002/chin.199910258
Autor:
Prakash J. Madhav, Christian N. Parker, Larry J. Wilson, Timothy W. Morris, Paul M. Hershberger, David T. Stanton
Publikováno v:
Journal of chemical information and computer sciences. 44(1)
A set of compounds consisting of a new and diverse collection of biarylamides was examined using quantitative structure-activity relationship techniques for the purpose of developing a model to describe inhibition of gram-positive bacterial growth (m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b7f4e12e3a526210a93e2852d797d6b
https://pubmed.ncbi.nlm.nih.gov/14741031
https://pubmed.ncbi.nlm.nih.gov/14741031
Autor:
Thomas P. Demuth, Paul M. Hershberger
Publikováno v:
Resolving the Antibiotic Paradox ISBN: 9781461372202
The issue of bacterial resistance to current classes of antibiotics is now well known and widely published (Levy, 1998; Chin and Marx, 1994). Indeed, unbeatable contagious infectious diseases have already generated significant medical crises in local
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd45fa65367e053fdbaf0de11e9848c5
https://doi.org/10.1007/978-1-4615-4897-3_13
https://doi.org/10.1007/978-1-4615-4897-3_13
Publikováno v:
Journal of the American Chemical Society. 111:4852-4856
La synthese du compose du titre se fait, sans resolution des intermediaires, via une photoaddition intramoleculaire d'une enaminone avec un alcoxyester vinylique
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a40dc5329a729e7d04a75478c47ea5f3
https://doi.org/10.1021/ja00195a042
https://doi.org/10.1021/ja00195a042
Publikováno v:
Tetrahedron Letters. 27:5177-5180
We describe herein the first stereoselective synthesis of the natural (−)-histrionicotoxin ring system, where the chirality is derived from L-glutamic acid. The key transformation involves intramolecular dioxolenone photocycloaddition of a substrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::798f5263b2d684d75b07069fade8843d
https://doi.org/10.1016/s0040-4039(00)85162-x
https://doi.org/10.1016/s0040-4039(00)85162-x
Publikováno v:
ChemInform. 20
La synthese du compose du titre se fait, sans resolution des intermediaires, via une photoaddition intramoleculaire d'une enaminone avec un alcoxyester vinylique
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58b0b4b8d9bee14d6a8ff13c43f7a53d
https://doi.org/10.1002/chin.198940323
https://doi.org/10.1002/chin.198940323