Výsledky vyhledávání - "Paul M. Daniel"

Akademický článek

Expression of CD133 and CD44 in glioblastoma stem cells correlates with cell proliferation, phenotype stability and intra-tumor heterogeneity.

Autor: Daniel V Brown, Gulay Filiz, Paul M Daniel, Frédéric Hollande, Sebastian Dworkin, Stephanie Amiridis, Nicole Kountouri, Wayne Ng, Andrew P Morokoff, Theo Mantamadiotis

Publikováno v: PLoS ONE, Vol 12, Iss 2, p e0172791 (2017)

Glioblastoma (GBM) is a heterogeneous tumor of the brain with a poor prognosis due to recurrence and drug resistance following therapy. Genome-wide profiling has revealed the existence of distinct GBM molecular subtypes that respond differently to ag

Externí odkaz: https://doaj.org/article/5a7ac15d4e7045b793592d822cc16281

Zobrazit plný text záznamu

Intratumor MAPK and PI3K signaling pathway heterogeneity in glioblastoma tissue correlates with CREB signaling and distinct target gene signatures

Autor: Andrew H. Kaye, Stanley S. Stylli, Gulay Filiz, Paul M. Daniel, Martin James Tymms, Theo Mantamadiotis, Robert G. Ramsay

Publikováno v: Experimental and molecular pathology. 105(1)

Limitations in discovering useful tumor biomarkers and drug targets is not only due to patient-to-patient differences but also due to intratumor heterogeneity. Heterogeneity arises due to the genetic and epigenetic variation of tumor cells in respons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e2cdf148600537ad1d2ef843582b7c4
https://pubmed.ncbi.nlm.nih.gov/29852183

Zobrazit plný text záznamu

PI3K activation in neural stem cells drives tumorigenesis which can be ameliorated by targeting the cAMP response element binding protein

Autor: Elizabeth Vincan, Karen G. Montgomery, Paul Waring, Colin W. Pouton, Yi Zhang, Dustin J. Flanagan, Daniel V Brown, Gulay Filiz, John M. Haynes, Terrance Grant Johns, Theo Mantamadiotis, Paul M. Daniel, Wayne A. Phillips, Michael Christie

BACKGROUND: Hyperactivation of phosphoinositide 3-kinase (PI3K) signaling is common in cancers, but the precise role of the pathway in glioma biology remains to be determined. Some understanding of PI3K signaling mechanisms in brain cancer comes from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b28a2a34b083720063fa59e8cefe933
https://europepmc.org/articles/PMC6140786/

Zobrazit plný text záznamu

Intratumoral MAPK and PI3K signaling pathway heterogeneity in glioblastoma tissue correlates with selective CREB signaling and specific functional gene signatures

Autor: Paul M. Daniel, Stanley S. Stylli, Martin J. Tymms, Theo Mantamadiotis, Robert G. Ramsay, Andrew H. Kaye, Gulay Filiz

Limitations in discovering useful tumor biomarkers and drug targets is not only due to patient-to-patient differences but also due to intratumoral heterogeneity. Heterogeneity arises due to the genetic and epigenetic variation of tumor cells in respo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb7e6ad528bfc9fa6f78836b58125277

Zobrazit plný text záznamu

PI3K activation in neural stem cells drives tumorigenesis which can be suppressed by targeting CREB

Autor: Yi Zhang, Paul Waring, Terrance Grant Johns, Gulay Filiz, Daniel V Brown, Paul M. Daniel, John M. Haynes, Elizabeth Vincan, Karen G. Montgomery, Theo Mantamadiotis, Michael Christie, Colin W. Pouton, Wayne A. Phillips, Dustin J. Flanagan

Hyperactivation of the PI3K signaling is common in human cancers, including gliomas, but the precise role of the pathway in glioma biology remains to be determined. Some limited understanding of PI3K signaling in brain cancer come from studies on neu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07d2511405c94e1768e17a4a0d55b35f

Zobrazit plný text záznamu

Sensitivity of GBM cells to cAMP agonist-mediated apoptosis correlates with CD44 expression and agonist resistance with MAPK signaling

Autor: Paul M. Daniel, Gulay Filiz, Theo Mantamadiotis

Publikováno v: Cell Death & Disease

In some cell types, activation of the second messenger cAMP leads to increased expression of proapoptotic Bim and subsequent cell death. We demonstrate that suppression of the cAMP pathway is a common event across many cancers and that pharmacologica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::783b2def861679d75cad334751ad20cb
https://pubmed.ncbi.nlm.nih.gov/27906173

Zobrazit plný text záznamu

Abstract 660: Integration of radiomics with 'omic' analyses to predict survival in newly diagnosed IDH-1 wild-type glioblastoma

Autor: Paul M. Daniel

Publikováno v: Cancer Research. 78:660-660

Glioblastoma (GBM) is the most commonly diagnosed glioma and has the poorest median survival of all brain tumours at only 14 months. Despite intensive characterisation of this disease through ‘omic' investigations which has led to the identificatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1ba7524e4e600ba7adc1ba3a54689e0f
https://doi.org/10.1158/1538-7445.am2018-660

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání