Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Paul M. Cullis"'
Publikováno v:
Angewandte Chemie (International ed. in English). 39(23)
Autor:
Alasdair W. Clark, Heba A. Kashmery, Glenn A. Burley, Ruggero Dondi, Paul M. Cullis, Andrew J. Fallows
Publikováno v:
European Journal of Inorganic Chemistry. 2014:4886-4895
This manuscript describes a one-pot method for the synthesis of size- and shape-selected silver nanoparticles (AgNPs) using Tollens' reagent [Ag(NH3)2OH] as the silver source. Sugar triazole ligands facilitate the formation of monodisperse AgNPs in w
Publikováno v:
Current Protocols in Nucleic Acid Chemistry
Pyrrole-imidazole polyamides (PAs) are a family of DNA-binding peptides that bind in the minor groove of double-stranded DNA (dsDNA) in a sequence-selective, programmable fashion. This protocol describes a detailed manual procedure for the solid-phas
Publikováno v:
Current Protocols in Nucleic Acid Chemistry
In this unit, the fully automated solid-phase synthetic strategy of hairpin Py-Im polyamides is described using triphosgene (BTC) as a coupling agent. This automated methodology is compatible with all the typical building blocks, enabling the facile
Publikováno v:
Tetrahedron Letters. 50:3657-3660
We present here the application of Grubbs’ 2nd generation catalyst for the ring-closing metathesis of electron-deficient α,β-unsaturated amides and esters leading to the synthesis of enantiopure azepinone and oxepinone derivatives on a carbohydra
Autor:
Paul M. Cullis, Dominic M. Laventine, Emma L. Evinson, Michelle Davies, Marcos D. García, Paul R. Jenkins
Publikováno v:
Tetrahedron. 65:4766-4774
We present here the stereoselective synthesis of a series of 2/3-N-pyrrolidine derivatives of glycosides produced by diastereoselective double reductive amination ring closure of 1,4-dicarbonyl compounds. These precursors were produced by tandem ozon
Autor:
Parvinder Hothi, Anna Roujeinikova, Khalid Abu Khadra, Paul M. Cullis, Michael Lee, Nigel S. Scrutton, David Leys
Publikováno v:
Monash University
Structure-activity correlations have been employed previously in the mechanistic interpretation of TTQ-dependent amine dehydrogenases using a series of para-substituted benzylamines. However, by combining the use of kinetic isotope effects (KIEs) and
Publikováno v:
Tetrahedron Letters. 46:2295-2298
Azepane rings have been constructed diastereoselectively upon a carbohydrate derivative utilising reductive amination and RCM. The stereochemistry of the ring junctions was confirmed by X-ray crystallography and NMR. Diastereoselective dihydroxylatio
Autor:
Emma L. Evinson, Paul M. Cullis, Paul R. Jenkins, John Fawcett, Dominic M. Laventine, Michelle Davies
Publikováno v:
Tetrahedron Letters. 46:307-310
1,4-Dicarbonyl derivatives of glycosides are produced by ozonolysis or Wacker oxidation. A stable ozonide is isolated and a carbonyl group reduced whilst maintaining the ozonide functionality. The 1,4-dicarbonyl compounds are converted to various N -
Autor:
Michael Lee, Christine M. J. Fauroux, Sally Freeman, Michael G. Gore, Kenneth T. Douglas, Paul M. Cullis
Publikováno v:
Journal of Medicinal Chemistry. 45:1363-1373
myo-Inositol monophosphatase (IMPase), the proposed target for lithium therapy for manic depression, is an important enzyme in the biosynthesis of second messengers. Earlier studies have shown that the IMPase-catalyzed hydrolysis of myo-inositol mono