Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Paul M. Coen"'
Autor:
Yujia (Susanna) Qiao, Terri L. Blackwell, Peggy M. Cawthon, Paul M. Coen, Steven R. Cummings, Giovanna Distefano, Samaneh Farsijani, Daniel E. Forman, Bret H. Goodpaster, Stephen B. Kritchevsky, Theresa Mau, Frederico G.S. Toledo, Anne B. Newman, Nancy W. Glynn
Publikováno v:
Journal of Sport and Health Science, Vol 13, Iss 5, Pp 621-630 (2024)
Background: Skeletal muscle energetics decline with age, and physical activity (PA) has been shown to offset these declines in older adults. Yet, many studies reporting these effects were based on self-reported PA or structured exercise interventions
Externí odkaz:
https://doaj.org/article/dc82c40127c14572a37112950489a8d5
Autor:
Diego Hernández-Saavedra, J. Matthew Hinkley, Lisa A. Baer, Kelsey M. Pinckard, Pablo Vidal, Shinsuke Nirengi, Andrea M. Brennan, Emily Y. Chen, Niven R. Narain, Valerie Bussberg, Vladimir V. Tolstikov, Michael A. Kiebish, Christina Markunas, Olga Ilkayeva, Bret H. Goodpaster, Christopher B. Newgard, Laurie J. Goodyear, Paul M. Coen, Kristin I. Stanford
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109083- (2024)
Summary: Exercise mediates tissue metabolic function through direct and indirect adaptations to acylcarnitine (AC) metabolism, but the exact mechanisms are unclear. We found that circulating medium-chain acylcarnitines (AC) (C12-C16) are lower in act
Externí odkaz:
https://doaj.org/article/1fa864323c024e6ea418512ba98137e4
Autor:
Maddalena Parafati, Shelby Giza, Tushar S. Shenoy, Jorge A. Mojica-Santiago, Meghan Hopf, Legrand K. Malany, Don Platt, Isabel Moore, Zachary A. Jacobs, Paul Kuehl, Jason Rexroat, Gentry Barnett, Christine E. Schmidt, William T. McLamb, Twyman Clements, Paul M. Coen, Siobhan Malany
Publikováno v:
npj Microgravity, Vol 9, Iss 1, Pp 1-11 (2023)
Abstract Microphysiological systems provide the opportunity to model accelerated changes at the human tissue level in the extreme space environment. Spaceflight-induced muscle atrophy experienced by astronauts shares similar physiological changes to
Externí odkaz:
https://doaj.org/article/561fc3bd700b47deb2d2845634e19221
Autor:
Andrew Philp, Paul M. Coen
Publikováno v:
Experimental Gerontology, Vol 182, Iss , Pp 112304- (2023)
Externí odkaz:
https://doaj.org/article/1b65fd31365948f0b2220099944e046f
Autor:
Tumpa Dutta, Nidhi Kapoor, Meril Mathew, Suban S. Chakraborty, Nathan P. Ward, Nicolas Prieto-Farigua, Aimee Falzone, James P. DeLany, Steven R. Smith, Paul M. Coen, Gina M. DeNicola, Stephen J. Gardell
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112218- (2023)
Summary: Metabolic routing of nicotinamide (NAM) to NAD+ or 1-methylnicotinamide (MeNAM) has impacts on human health and aging. NAM is imported by cells or liberated from NAD+. The fate of 2H4-NAM in cultured cells, mice, and humans was determined by
Externí odkaz:
https://doaj.org/article/0ba5dbe77c3a4d6aa88795f4b3f2d9bd
Autor:
Venugopalan D. Nair, Yongchao Ge, Side Li, Hanna Pincas, Nimisha Jain, Nitish Seenarine, Mary Anne S. Amper, Bret H. Goodpaster, Martin J. Walsh, Paul M. Coen, Stuart C. Sealfon
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Exercise has multi-systemic benefits and attenuates the physiological impairments associated with aging. Emerging evidence suggests that circulating exosomes mediate some of the beneficial effects of exercise via the transfer of microRNAs between tis
Externí odkaz:
https://doaj.org/article/e60e757d0a6745a28102a79b0d6f840a
Autor:
Giovanna Distefano, Robert A. Standley, Xiaolei Zhang, Elvis A. Carnero, Fanchao Yi, Heather H. Cornnell, Paul M. Coen
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 9, Iss 2, Pp 279-294 (2018)
Abstract Background The concept of mitochondrial dysfunction in ageing muscle is highly controversial. In addition, emerging evidence suggests that reduced muscle oxidative capacity and efficiency underlie the aetiology of mobility loss in older adul
Externí odkaz:
https://doaj.org/article/588cd1efe4774b278ab7aeac197c1b83
Publikováno v:
Frontiers in Physiology, Vol 9 (2019)
Sarcopenia is the loss of muscle mass, strength, and physical function that is characteristic of aging. The progression of sarcopenia is gradual but may be accelerated by periods of muscle loss during physical inactivity secondary to illness or injur
Externí odkaz:
https://doaj.org/article/f7c26a364ff440a0ba6476740c4fd4b1
Publikováno v:
Obesity. 31:1338-1346
Autor:
J. Matthew Hinkley, Gong Xin Yu, Robert A. Standley, Giovanna Distefano, Vladimir Tolstikov, Niven R. Narain, Bennett P. Greenwood, Shraddha Karmacharya, Michael A. Kiebish, Elvis Alvarez Carnero, Fanchao Yi, Rick B. Vega, Bret H. Goodpaster, Stephen J. Gardell, Paul M. Coen
Publikováno v:
The Journal of Physiology. 601:2165-2188