Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Paul M. Brennan"'
Publikováno v:
World Neurosurgery: X, Vol 25, Iss , Pp 100409- (2025)
Objective: Return to play (RTP) decisions after cranial surgery are important to patients. Most published data relate to RTP following sports-related brain injury. This study investigated factors that influence neurosurgical RTP decision-making follo
Externí odkaz:
https://doaj.org/article/7abe3bbb8d0641c5982eabcba7d94b23
Publikováno v:
BMC Medicine, Vol 21, Iss 1, Pp 1-10 (2023)
Abstract Background Elevated standardised mortality ratio of cardiovascular diseases (CVD) in patients with brain tumours may result from differences in the CVD incidences and cardiovascular risk factors. We compared the risk of CVD among patients wi
Externí odkaz:
https://doaj.org/article/0de440f204b34b6f9b5d7deb4dafc592
Autor:
Emma L. O’Dowd, Samuel W. D. Merriel, Vinton W. T. Cheng, Sam Khan, Lynne M. Howells, Dipesh P. Gopal, Elizabeth A. Roundhill, Paul M. Brennan, Philip A. J. Crosbie, Richard D. Neal, Karen Brown, Emma J. Crosbie, David R. Baldwin
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-11 (2023)
Abstract Background Global annual cancer incidence is forecast to rise to 27.5 M by 2040, a 62% increase from 2018. For most cancers, prevention and early detection are the most effective ways of reducing mortality. This study maps trials in cancer s
Externí odkaz:
https://doaj.org/article/1225c6be837041a58d5618e2cacd19b9
Autor:
Alexandra Sala, James M. Cameron, Paul M. Brennan, Emma J. Crosbie, Tom Curran, Ewan Gray, Pierre Martin-Hirsch, David S. Palmer, Ihtesham U. Rehman, Nicholas J. W. Rattray, Matthew J. Baker
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-15 (2023)
Abstract The advances in cancer research achieved in the last 50 years have been remarkable and have provided a deeper knowledge of this disease in many of its conceptual and biochemical aspects. From viewing a tumor as a ‘simple’ aggregate of mu
Externí odkaz:
https://doaj.org/article/580b7a572fd543ac8ff0b8e90d364bf2
Autor:
Joseph Brennan, Michael T. C. Poon, Edward Christopher, Olivia Fulton, Carol Porteous, Paul M. Brennan
Publikováno v:
Trials, Vol 24, Iss 1, Pp 1-7 (2023)
Abstract Background Patient and public involvement (PPI) in clinical trial design contributes to ensuring the research objectives and outcome measures are relevant to patients. The minimal clinically important difference (MCID) in the primary outcome
Externí odkaz:
https://doaj.org/article/a89bfe3f975041c282eca7a5f86be326
Autor:
Siobhan Connal, James M. Cameron, Alexandra Sala, Paul M. Brennan, David S. Palmer, Joshua D. Palmer, Haley Perlow, Matthew J. Baker
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-18 (2023)
Abstract Cancer is a worldwide pandemic. The burden it imposes grows steadily on a global scale causing emotional, physical, and financial strains on individuals, families, and health care systems. Despite being the second leading cause of death worl
Externí odkaz:
https://doaj.org/article/0add3915484d449084d92304df986c5d
Autor:
Karolis Zienius, Mio Ozawa, Willie Hamilton, Will Hollingworth, David Weller, Lorna Porteous, Yoav Ben-Shlomo, Robin Grant, Paul M. Brennan
Publikováno v:
BMC Neurology, Vol 22, Iss 1, Pp 1-10 (2022)
Abstract Background Patients with brain tumours often present with non-specific symptoms. Correctly identifying who to prioritise for urgent brain imaging is challenging. Brain tumours are amongst the commonest cancers diagnosed as an emergency prese
Externí odkaz:
https://doaj.org/article/da90a757574a4203b6dfa9473c7ecbff
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
ObjectiveWe aimed to examine brain tumour grade, a marker of biological aggressiveness, tumour size and cancer treatment are associated with cerebrovascular mortality among patients with malignant glioma, the most common and aggressive type of brain
Externí odkaz:
https://doaj.org/article/c3945bb1fa5341989a820c1870e1d7c7
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-9 (2021)
Abstract Background Malignant glioma cell line models are integral to pre-clinical testing of novel potential therapies. Accurate prediction of likely efficacy in the clinic requires that these models are reliable and consistent. We assessed this by
Externí odkaz:
https://doaj.org/article/da02e9ee3efb494ea3436c9175d4c261
Autor:
Hemanth R. Nelvagal, Samantha L. Eaton, Sophie H. Wang, Elizabeth M. Eultgen, Keigo Takahashi, Steven Q. Le, Rachel Nesbitt, Joshua T. Dearborn, Nicholas Siano, Ana C. Puhl, Patricia I. Dickson, Gerard Thompson, Fraser Murdoch, Paul M. Brennan, Mark Gray, Stephen N. Greenhalgh, Peter Tennant, Rachael Gregson, Eddie Clutton, James Nixon, Chris Proudfoot, Stefano Guido, Simon G. Lillico, C. Bruce A. Whitelaw, Jui-Yun Lu, Sandra L. Hofmann, Sean Ekins, Mark S. Sands, Thomas M. Wishart, Jonathan D. Cooper
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 20 (2022)
CLN1 disease, also called infantile neuronal ceroid lipofuscinosis (NCL) or infantile Batten disease, is a fatal neurodegenerative lysosomal storage disorder resulting from mutations in the CLN1 gene encoding the soluble lysosomal enzyme palmitoyl-pr
Externí odkaz:
https://doaj.org/article/fb7adb2cd6174d5a9c38555ece25def7