Zobrazeno 1 - 10
of 227
pro vyhledávání: '"Paul M. Allen"'
Autor:
Samantha A. Hsieh, Paul M. Allen
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The interplay between the immune system and the microbiota in the human intestine dictates states of health vs. disease. Polysaccharide capsules are critical elements of bacteria that protect bacteria against environmental and host factors, including
Externí odkaz:
https://doaj.org/article/98f2da49f9cf4e21aaaa75048d189357
Autor:
Joseph L. Ransdell, Edward Dranoff, Brandon Lau, Wan-Lin Lo, David L. Donermeyer, Paul M. Allen, Jeanne M. Nerbonne
Publikováno v:
Cell Reports, Vol 19, Iss 3, Pp 532-544 (2017)
Summary: The resurgent component of voltage-gated Na+ (Nav) currents, INaR, has been suggested to provide the depolarizing drive for high-frequency firing and to be generated by voltage-dependent Nav channel block (at depolarized potentials) and unbl
Externí odkaz:
https://doaj.org/article/e856e8bc6d5743638b7f92c3b58afa42
Autor:
Ashley eViehmann Milam, Paul M. Allen
Publikováno v:
Frontiers in Immunology, Vol 6 (2015)
To investigate how CD4+ T cells function against a bacterial pathogen, we generated a Listeria monocytogenes-specific CD4+ T cell model. In this system, two TCRtg mouse lines, LLO56 and LLO118 recognize the same immunodominant epitope (LLO190-205) of
Externí odkaz:
https://doaj.org/article/4f55162dd04f4121b00fa9b946656825
Autor:
Paul M. Allen, Marina Cella, Augusto C. Ochoa, Jovanny Zabaleta, Leigh A. O'Mara, Paulo C. Rodriguez, Lyse A. Norian
Supplementary Figure 1 from Tumor-Infiltrating Regulatory Dendritic Cells Inhibit CD8+ T Cell Function via l-Arginine Metabolism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4079c42a1c3aecca63281fc28e3c7c10
https://doi.org/10.1158/0008-5472.22380989.v1
https://doi.org/10.1158/0008-5472.22380989.v1
Autor:
Paul M. Allen, Marina Cella, Augusto C. Ochoa, Jovanny Zabaleta, Leigh A. O'Mara, Paulo C. Rodriguez, Lyse A. Norian
Supplementary Figure 2 from Tumor-Infiltrating Regulatory Dendritic Cells Inhibit CD8+ T Cell Function via l-Arginine Metabolism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::774354c2fe6f36e3533dc913831f5ff2
https://doi.org/10.1158/0008-5472.22380986.v1
https://doi.org/10.1158/0008-5472.22380986.v1
Autor:
Paul M. Allen, Marina Cella, Augusto C. Ochoa, Jovanny Zabaleta, Leigh A. O'Mara, Paulo C. Rodriguez, Lyse A. Norian
Dendritic cells (DC) have a critical effect on the outcome of adaptive immune responses against growing tumors. Whereas it is generally assumed that the presence of phenotypically mature DCs should promote protective antitumor immunity, evidence to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a918aca61017984262c24dc575e52371
https://doi.org/10.1158/0008-5472.c.6499727.v1
https://doi.org/10.1158/0008-5472.c.6499727.v1
Autor:
Mingyu He, Kate Roussak, Feiyang Ma, Nicholas Borcherding, Vince Garin, Mike White, Charles Schutt, Trine I. Jensen, Yun Zhao, Courtney A. Iberg, Kairav Shah, Himanshi Bhatia, Daniel Korenfeld, Sabrina Dinkel, Judah Gray, Alina Ulezko Antonova, Stephen Ferris, David Donermeyer, Cecilia Lindestam Arlehamn, Matthew M. Gubin, Jingqin Luo, Laurent Gorvel, Matteo Pellegrini, Alessandro Sette, Thomas Tung, Rasmus Bak, Robert L. Modlin, Ryan C. Fields, Robert D. Schreiber, Paul M. Allen, Eynav Klechevsky
Publikováno v:
He, M, Roussak, K, Ma, F, Borcherding, N, Garin, V, White, M, Schutt, C, Jensen, T I, Zhao, Y, Iberg, C A, Shah, K, Bhatia, H, Korenfeld, D, Dinkel, S, Gray, J, Ulezko Antonova, A, Ferris, S, Donermeyer, D, Lindestam Arlehamn, C, Gubin, M M, Luo, J, Gorvel, L, Pellegrini, M, Sette, A, Tung, T, Bak, R, Modlin, R L, Fields, R C, Schreiber, R D, Allen, P M & Klechevsky, E 2023, ' CD5 expression by dendritic cells directs T cell immunity and sustains immunotherapy responses ', Science, vol. 379, no. 6633, eabg2752 . https://doi.org/10.1126/science.abg2752
The induction of proinflammatory T cells by dendritic cell (DC) subtypes is critical for antitumor responses and effective immune checkpoint blockade (ICB) therapy. Here, we show that human CD1c + CD5 + DCs are reduced in melanoma-affected lymph node
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bb58f3075eb648887329399a6257400
https://pure.au.dk/portal/da/publications/cd5-expression-by-dendritic-cells-directs-t-cell-immunity-and-sustains-immunotherapy-responses(0a5862aa-3391-473b-9491-d06b9b57ccb2).html
https://pure.au.dk/portal/da/publications/cd5-expression-by-dendritic-cells-directs-t-cell-immunity-and-sustains-immunotherapy-responses(0a5862aa-3391-473b-9491-d06b9b57ccb2).html
Autor:
Ranit Kedmi, Tariq A. Najar, Kailin R. Mesa, Allyssa Grayson, Lina Kroehling, Yuhan Hao, Stephanie Hao, Maria Pokrovskii, Mo Xu, Jhimmy Talbot, Jiaxi Wang, Joe Germino, Caleb A. Lareau, Ansuman T. Satpathy, Mark S. Anderson, Terri M. Laufer, Iannis Aifantis, Juliet M. Bartleson, Paul M. Allen, Helena Paidassi, James M. Gardner, Marlon Stoeckius, Dan R. Littman
Publikováno v:
Nature, vol 610, iss 7933
Nature
Nature, 2022, 610 (7933), pp.737-743. ⟨10.1038/s41586-022-05089-y⟩
Nature
Nature, 2022, 610 (7933), pp.737-743. ⟨10.1038/s41586-022-05089-y⟩
The mutualistic relationship of gut-resident microbiota and the host immune system promotes homeostasis that ensures maintenance of the microbial community and of a largely non-aggressive immune cell compartment1,2. The consequences of disturbing thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a84cab211530b906d38b48d797acdf56
https://escholarship.org/uc/item/4zh799vz
https://escholarship.org/uc/item/4zh799vz
Autor:
Ashley A. Viehmann Milam, Juliet M. Bartleson, Stephen Horvath, David L. Donermeyer, Paul M. Allen, Yu Xia, Takeshi Egawa
Publikováno v:
Nature immunology
T follicular helper (TFH) cells are critical in adaptive immune responses to pathogens and vaccines; however, what drives the initiation of their developmental program remains unclear. Studies suggest that a T cell antigen receptor (TCR)-dependent me
Autor:
Bernd H. Zinselmeyer, Thaddeus S. Stappenbeck, David L. Donermeyer, Nathan T. Porter, Samantha Hsieh, Gregory W. Strout, Eric C. Martens, Paul M. Allen, Stephen Horvath, Nan Zhang, Brian Saunders
Publikováno v:
The Journal of Immunology. 204:1035-1046
Bacteria express multiple diverse capsular polysaccharides (CPSs) for protection against environmental and host factors, including the host immune system. Using a mouse TCR transgenic CD4+ T cell, BθOM, that is specific for B. thetaiotaomicron and a