Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Paul M. Keller"'
Publikováno v:
BioTechniques, Vol 25, Iss 1, Pp 98-106 (1998)
Recently developed PCR-based reverse transcriptase (RT) assays are useful in the detection of retroviruses since they are approximately a millionfold more sensitive than conventional RT assays. However, these assays are both labor- and time-intensive
Externí odkaz:
https://doaj.org/article/1ef21dab533b47f9a8f696d4b7833bd1
Autor:
Jessica L. Schneck, Charlie Y. Mo, Zachary M Hostetler, Anthony J. Jurewicz, Paul M. Keller, Trevor Selwood, Amy Quinn, Andrew J. Pope, Matthew J. Culyba, Widdowson Katherine L, Rahul M. Kohli, Jeffrey M. Kubiak
Publikováno v:
ACS Infectious Diseases. 4:349-359
The RecA/LexA axis of the bacterial DNA damage (SOS) response is a promising, yet non-traditional drug target. The SOS response is initiated upon genotoxic stress, when RecA, a DNA damage sensor, induces LexA, the SOS repressor, to undergo autoproteo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31a7888f32c398e2cbcc453832db48f9
https://doi.org/10.1021/acsinfecdis.7b00122
https://doi.org/10.1021/acsinfecdis.7b00122
Autor:
Vicki A, Morrison, Michael N, Oxman, Myron J, Levin, Kenneth E, Schmader, John C, Guatelli, Robert F, Betts, Larry D, Gelb, Constance T, Pachucki, Susan K, Keay, Barbara, Menzies, Marie R, Griffin, Carol A, Kauffman, Adriana R, Marques, John F, Toney, Michael S, Simberkoff, Richard, Serrao, Robert D, Arbeit, John W, Gnann, Richard N, Greenberg, Mark, Holodniy, Wendy A, Keitel, Shingshing S, Yeh, Larry E, Davis, George E, Crawford, Kathy M, Neuzil, Gary R, Johnson, Jane H, Zhang, Rith, Harbecke, Ivan S F, Chan, Paul M, Keller, Heather M, Williams, Kathy D, Boardman, Jeffrey L, Silber, Paula W, Annunziato, J F, Toney
Publikováno v:
The Journal of Infectious Diseases. 208:559-563
Background. After completion of the Shingles Prevention Study (SPS; Department of Veterans Affairs Cooperative Studies Program Number 403), SPS participants who had initially received placebo were offered investigational zoster vaccine without charge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e40304f8a8b1a4814f972bf828f6742
https://doi.org/10.1093/infdis/jit182
https://doi.org/10.1093/infdis/jit182
Autor:
John C. Guatelli, Carol A. Kauffman, Constance T. Pachucki, Myron J. Levin, Ruth Harbecke, Adriana Marques, Barbara Menzies, Robert F. Betts, Ivan S. F. Chan, Marie R. Griffin, Michael N. Oxman, Vicki A. Morrison, Susan Keay, Lawrence D. Gelb, Paula W. Annunziato, Jane H. Zhang, Xiaoming Li, Gary R. Johnson, John F. Toney, Paul M. Keller, Kenneth E. Schmader
Publikováno v:
Clinical Infectious Diseases. 55:1320-1328
Herpes zoster (HZ) results from the reactivation, multiplication, and spread of varicella-zoster virus (VZV) that remains latent in sensory neurons following earlier primary VZV infection (ie, varicella or chickenpox) [1]. Department of Veterans Affa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e821d9c2976675fd2bbcba96fe43468
https://doi.org/10.1093/cid/cis638
https://doi.org/10.1093/cid/cis638
Autor:
Rosalie Matico, Michael L. Moore, Dennis Murphy, Paul M. Keller, Mark R. Harpel, John A. Krawiec, John J. Trill, Krista B. Goodman, Daryl A. Scherzer, Deyou Sha, Da-Yuan Wang, Thomas D. Sweitzer, Jeffrey A. Lieby, Maria Cichy-Knight, Dominic Suarez, Michael Jaye, Mui Cheung, Eric S. Manas, Dennis Lee, Sarah E. Dowdell, Dean E. McNulty, Benjamin K. Schwartz, Michael Jonathan Bury, Allison K. Dunn, Roland S. Annan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:27-30
Endothelial lipase (EL) activity has been implicated in HDL catabolism, vascular inflammation, and atherogenesis, and inhibitors are therefore expected to be useful for the treatment of cardiovascular disease. Sulfonylfuran urea 1 was identified in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::198b3db1ae75b39ec49d7ce6b2d23ed0
https://doi.org/10.1016/j.bmcl.2008.11.033
https://doi.org/10.1016/j.bmcl.2008.11.033
Autor:
Sara H. Thrall, Rosalie Matico, Michael Jaye, Paul M. Keller, Benjamin J. Schwartz, Timothy Rust, Dennis J. Murphy, Anthony J. Jurewicz, Krawiec John A, Mark R. Harpel, John J. Trill
Publikováno v:
SLAS Discovery. 13:468-475
Endothelial lipase (EL) is a 482-amino-acid protein from the triglyceride lipase gene family that uses a Ser-His-Asp triad for catalysis. Its expression in endothelial cells and preference for phospholipids rather than triglycerides are unique. Anima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e3ba42867dd6fef670c2bc8755a7082
https://doi.org/10.1177/1087057108319738
https://doi.org/10.1177/1087057108319738
Autor:
Hongxia Fan, Rosemarie Kelly, Andrea Woods, Hugh A. George, Tessie McNeely, Maria C Losada, Leslie Cope, Kathrin U. Jansen, Joseph G. Joyce, Paul M. Keller, Xiaorong Wei, Myra B. Kurtz, Louise Pitt, Loren D. Schultz, Elizabeth K. Leffel, Robert W. Hepler, Alka Bansal, James C. Cook, Steven L. Cohen, Gina Zang
Publikováno v:
Vaccine. 24:1501-1514
Infection by Bacillus anthracis is preventable by prophylactic vaccination with several naturally derived and recombinant vaccine preparations. Existing data suggests that protection is mediated by antibodies directed against the protective antigen (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fab67d670a510c0f8fe74aa4fce6cc62
https://doi.org/10.1016/j.vaccine.2005.10.018
https://doi.org/10.1016/j.vaccine.2005.10.018
Autor:
Qiuwei Xu, Arthur M. Friedlander, Wesley L. Shoop, Lani Indrawati, James C. Cook, Su Wang, Robert W. Hepler, Donald J. Chabot, Thomas Stambaugh, Michael J. Caulfield, Joseph G. Joyce, Miguel Aste-Amezaga, Mark W. Bruner, Paul M. Keller
Publikováno v:
Journal of Biological Chemistry. 281:4831-4843
The capsular polypeptide of Bacillus anthracis is composed of a unique polyglutamic acid polymer in which D-glutamate monomers are joined by gamma-peptidyl bonds. The capsule is poorly immunogenic, and efforts at exploiting the polymer for vaccine de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16840d8843174bd9a1c6688b6ad8f248
https://doi.org/10.1074/jbc.m509432200
https://doi.org/10.1074/jbc.m509432200
Autor:
Daniel J. DiStefano, Alan R. Shaw, Laura Mallette, Marianne Maliga, Paul M. Keller, H Fred Clark, Gregory Kulnis, Nikolai Kraiouchkine
Publikováno v:
Journal of Clinical Microbiology. 43:5876-5880
Rotavirus is the most common cause of severe dehydrating gastroenteritis in infants. To date, 10 different serotypes of rotavirus have been identified in human stools. While four or five serotypes dominate, serotype circulation varies with season and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34010f264194b241318ac481d7c42de8
https://doi.org/10.1128/jcm.43.12.5876-5880.2005
https://doi.org/10.1128/jcm.43.12.5876-5880.2005
Autor:
Paul M. Keller, John W. Shiver, Victor M. Garsky, Mary-Ellen Davies, Roxana Ionescu, Jiang Fan, Jon H. Condra, Helen C. Perry, Melanie Horton, Li Shi, Jason J. Z. Liao, Gwen J Heidecker, Xiaoping Liang, Michael Chastain, Emilio A. Emini, Yvette Rippeon, Joseph G. Joyce, Tong-Ming Fu, Michael P. Citron, Craig T. Przysiecki
Publikováno v:
Vaccine. 22:2993-3003
A universal influenza virus vaccine that does not require frequent updates and/or annual immunizations will offer significant advantages over current seasonal flu vaccines. The highly conserved influenza virus A M2 membrane protein has been previousl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1238143103e6c5b2fff7b8094376b954
https://doi.org/10.1016/j.vaccine.2004.02.021
https://doi.org/10.1016/j.vaccine.2004.02.021