Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Paul M. Guyo"'
Publikováno v:
Western Indian Ocean Journal of Marine Science; Vol. 20 No. 1 (2021); 125-136
Endophytes are bacteria or fungi living asymptomatically in the internal tissues of plants. They are symbiotic in nature and can be exploited for novel bioactive metabolites with applications in agriculture, medicine and industry. Mangrove fungal end
The preparation and Birch reduction of a series of electron-deficient pyrroles is described. This methodology allows the synthesis of a variety of C-2 substituted 3-pyrrolines‡ in good to excellent yields. The role of various activating groups (ami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edffe426560777b57db93cc3cd3f114b
https://doi.org/10.1039/a707661d
https://doi.org/10.1039/a707661d
Autor:
Herman O. Sintim, John D. Harling, Paul M. Guyo, Timothy J. Donohoe, Karl W. Ace, Leena Sisangia, Andrew R. Cowley
Publikováno v:
Chemistry - A European Journal. 11:4227-4238
A new synthesis of the 20S proteasome inhibitor clasto-lactacystin beta-lactone is described. Our route to this important natural product involves the partial reduction of an electron deficient pyrrole as a key step. By judicious choice of enolate co
Publikováno v:
Tetrahedron Letters. 40:435-438
The Birch reduction has been applied to electron-deficient pyrroles substituted with a chiral auxiliary at the C-2 position. Using either 8-phenylmenthol or trans -2-(α-cumyl)cyclohexanol (TCC) as auxiliaries, high levels of stereoselectivity were o
Autor:
Timothy J. Donohoe, Paul M. Guyo
Publikováno v:
ChemInform. 28
Publikováno v:
ChemInform. 28
ChemInform Abstract: Reduction of Electron-Deficient Pyrroles Using Group I and II Metals in Ammonia
Publikováno v:
ChemInform. 29
The preparation and Birch reduction of a series of electron-deficient pyrroles is described. This methodology allows the synthesis of a variety of C-2 substituted 3-pyrrolines‡ in good to excellent yields. The role of various activating groups (ami
Publikováno v:
ChemInform. 29
The Birch reduction of electron-deficient 3-substituted pyrroles is described. Use of a reductive alkylation procedure involving sodium metal in liquid ammonia gave good yields of 4-alkyl-2-pyrrolines. The identity of these products was proven by an
Publikováno v:
ChemInform. 30
The Birch reduction has been applied to electron-deficient pyrroles substituted with a chiral auxiliary at the C-2 position. Using either 8-phenylmenthol or trans -2-(α-cumyl)cyclohexanol (TCC) as auxiliaries, high levels of stereoselectivity were o
Publikováno v:
ChemInform. 31
The Birch reduction of both pyrroles and furans can be quenched with an aldehyde electrophile, thus constituting a reductive aldol reaction. Although the reaction was not stereoselective, the pyrrolines derived from reduction of pyrroles could be oxi