Differential ligand binding affinities of human estrogen receptor-α isoforms.

Autor: Amanda H Y Lin, Rachel W S Li, Eva Y W Ho, George P H Leung, Susan W S Leung, Paul M Vanhoutte, Ricky Y K Man

Publikováno v: PLoS ONE, Vol 8, Iss 4, p e63199 (2013)

Rapid non-genomic effects of 17β-estradiol are elicited by the activation of different estrogen receptor-α isoforms. Presence of surface binding sites for estrogen have been identified in cells transfected with full-length estrogen receptor-α66 (E

Externí odkaz: https://doaj.org/article/92b20d56ea004f4a8e31b58a69038324

A synthetic chloride channel relaxes airway smooth muscle of the rat.

Autor: Kwok-hei Yau, Judith Choi-wo Mak, Susan Wai-sum Leung, Dan Yang, Paul M Vanhoutte

Publikováno v: PLoS ONE, Vol 7, Iss 9, p e45340 (2012)

Synthetic ion channels may have potential therapeutic applications, provided they possess appropriate biological activities. The present study was designed to examine the ability of small molecule-based synthetic Cl(-) channels to modulate airway smo

Externí odkaz: https://doaj.org/article/743427a3962247e3b6acd4522e82a4ca

Transgenic mice over-expressing ET-1 in the endothelial cells develop systemic hypertension with altered vascular reactivity.

Autor: Justin Wai-Chung Leung, Wing Tak Wong, Hon Wai Koon, Fong Ming Mo, Sidney Tam, Yu Huang, Paul M Vanhoutte, Stephen Sum Man Chung, Sookja Kim Chung

Publikováno v: PLoS ONE, Vol 6, Iss 11, p e26994 (2011)

Endothelin-1 (ET-1) is a potent vasoconstrictor involved in the regulation of vascular tone and implicated in hypertension. However, the role of small blood vessels endothelial ET-1 in hypertension remains unclear. The present study investigated the

Externí odkaz: https://doaj.org/article/bdf878c5bcd743a1beff9b3e7cb75f32

TNFα induces endothelial dysfunction in rheumatoid arthritis via LOX-1 and arginase 2: reversal by monoclonal TNFα antibodies

Autor: Giovanni G. Camici, Melroy X. Miranda, Reijo Laaksonen, Simon Kraler, Branko Simic, Jari Metso, Lydia Ntari, Rose Cydecian, Thomas F. Lüscher, Margot Crucet, Matti Jauhiainen, Niki Karagianni, Frank Ruschitzka, Oliver Distler, Adrian Ciurea, Lena Schwarz, Vera Fehr, Luca Liberale, George Kollias, Nicole R. Bonetti, Caroline Ospelt, Alexander Akhmedov, Paul M. Vanhoutte, Mohammad Amrollahi-Sharifabadi, Rita Zilinyi

Aims Rheumatoid arthritis (RA) is a chronic inflammatory disease affecting joints and blood vessels. Despite low levels of low-density lipoprotein cholesterol (LDL-C), RA patients exhibit endothelial dysfunction and are at increased risk of death fro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45cf2066ba84b5281857d3640d6790f4
https://www.zora.uzh.ch/id/eprint/198705/

Natriuretic peptides relax human intrarenal arteries through natriuretic peptide receptor type-A recapitulated by soluble guanylyl cyclase agonists

Autor: Anna Federlein, Boye L. Jensen, Mia Jensen, Kirsten Madsen, Pernille Lund Hansen, Andreas Frees, Paul M. Vanhoutte, Lars Lund, Kasper Bostlund Assersen, Anja Toft

Publikováno v: Frees, A, Assersen, K B, Jensen, M, Hansen, P B L, Vanhoutte, P M, Madsen, K, Federlein, A, Lund, L, Toft, A & Jensen, B L 2021, ' Natriuretic peptides relax human intrarenal arteries through natriuretic peptide receptor type-A recapitulated by soluble guanylyl cyclase agonists ', Acta Physiologica, vol. 231, no. 3, e13565 . https://doi.org/10.1111/apha.13565

Aim: Natriuretic peptides, BNP and ANP increase renal blood flow in experimental animals. The signalling pathway in human kidney vasculature is unknown. It was hypothesized that BNP and ANP cause endothelium-independent relaxation of human intrarenal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aebe085dcdb37485a780ccabe697858
https://findresearcher.sdu.dk:8443/ws/files/175292777/apha.13565.pdf