Zobrazeno 1 - 10
of 174
pro vyhledávání: '"Paul M Thomas"'
Autor:
Nebiyu A Abshiru, Jacek W Sikora, Jeannie M Camarillo, Juliette A Morris, Philip D Compton, Tak Lee, Yaseswini Neelamraju, Samuel Haddox, Caroline Sheridan, Martin Carroll, Larry D Cripe, Martin S Tallman, Elisabeth M Paietta, Ari M Melnick, Paul M Thomas, Francine E Garrett-Bakelman, Neil L Kelleher
Publikováno v:
PLoS ONE, Vol 15, Iss 10, p e0240829 (2020)
Histone post-translational modifications (PTMs) create a powerful regulatory mechanism for maintaining chromosomal integrity in cells. Histone acetylation and methylation, the most widely studied histone PTMs, act in concert with chromatin-associated
Externí odkaz:
https://doaj.org/article/9fa008740c854e4ca5435d953e809e65
Autor:
Philip A Gruppuso, Joan M Boylan, Valerie Zabala, Nicola Neretti, Nebiyu A Abshiru, Jacek W Sikora, Emma H Doud, Jeannie M Camarillo, Paul M Thomas, Neil L Kelleher, Jennifer A Sanders
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0203351 (2018)
Chromatin structure, a key contributor to the regulation of gene expression, is modulated by a broad array of histone post-translational modifications (PTMs). Taken together, these "histone marks" comprise what is often referred to as the "histone co
Externí odkaz:
https://doaj.org/article/1caaee12c994468fb5449398614069e4
Autor:
Yuichi Ichikawa, Caitlin F Connelly, Alon Appleboim, Thomas CR Miller, Hadas Jacobi, Nebiyu A Abshiru, Hsin-Jung Chou, Yuanyuan Chen, Upasna Sharma, Yupeng Zheng, Paul M Thomas, Hsuiyi V Chen, Vineeta Bajaj, Christoph W Müller, Neil L Kelleher, Nir Friedman, Daniel NA Bolon, Oliver J Rando, Paul D Kaufman
Publikováno v:
eLife, Vol 6 (2017)
The repeating subunit of chromatin, the nucleosome, includes two copies of each of the four core histones, and several recent studies have reported that asymmetrically-modified nucleosomes occur at regulatory elements in vivo. To probe the mechanisms
Externí odkaz:
https://doaj.org/article/24b6ece5ed4441b78cfba5f0e8e8b723
Autor:
Hui Ye, Rakesh Mandal, Adam Catherman, Paul M Thomas, Neil L Kelleher, Chrysanthy Ikonomidou, Lingjun Li
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e92831 (2014)
In the developing mammalian brain, inhibition of NMDA receptor can induce widespread neuroapoptosis, inhibit neurogenesis and cause impairment of learning and memory. Although some mechanistic insights into adverse neurological actions of these NMDA
Externí odkaz:
https://doaj.org/article/03191a9c4f1243cd815670da9a15a0b3
Autor:
Ashley N. Ives, Henry A. Dunn, Hamid Samareh Afsari, Henrique dos Santos Seckler, Max J. Foroutan, Erica Chavez, Rafael D. Melani, Ryan T. Fellers, Richard D. LeDuc, Paul M. Thomas, Kirill A. Martemyanov, Neil L. Kelleher, Reza Vafabakhsh
Publikováno v:
Journal of the American Chemical Society. 144(50)
G protein-coupled receptors (GPCRs) are the largest family of membrane receptors in humans. They mediate nearly all aspects of human physiology and thus are of high therapeutic interest. GPCR signaling is regulated in space and time by receptor phosp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfb9ecbb39e54343f7eba929c23b7e8c
https://pubmed.ncbi.nlm.nih.gov/36475650
https://pubmed.ncbi.nlm.nih.gov/36475650
Autor:
Panagiotis Ntziachristos, Ali Shilatifard, John D. Crispino, Suresh Kumar, Joseph Weinstock, Neil L. Kelleher, Giuseppe Basso, Benedetta Accordi, Maddalena Paganin, Silvia Bresolin, Valentina Serafin, Beat Bornhauser, Jean-Pierre Bourquin, Irawati Kandela, Christine Mantis, Beatrix Ueberheide, Stephen Kelly, Alexandros Strikoudis, Pieter Van Vlierberghe, Clayton K. Collings, Elizabeth T. Bartom, Radhika Rawat, Lu Wang, Yoh-hei Takahashi, Emily J. Rendleman, Stacy A. Marshall, Steven Goosens, Geert Berx, Niels Vandamme, Sofie Peirs, Nobuko Hijiya, Nebiyu A. Abshiru, Young Ah Goo, Paul M. Thomas, Ivan Sokirniy, Hui Wang, Charles Grove, Jian Wu, Feng Wang, Andrew G. Volk, Megan R. Johnson, Kenneth K. Wang, Blanca T. Gutierrez-Diaz, Yixing Zhu, Kelly M. Arcipowski, Carlos A. Martinez, Qi Jin
Supplementary Table 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2058d90704989c35c0a745444483d25a
https://doi.org/10.1158/1078-0432.22474514.v1
https://doi.org/10.1158/1078-0432.22474514.v1
Autor:
Panagiotis Ntziachristos, Ali Shilatifard, John D. Crispino, Suresh Kumar, Joseph Weinstock, Neil L. Kelleher, Giuseppe Basso, Benedetta Accordi, Maddalena Paganin, Silvia Bresolin, Valentina Serafin, Beat Bornhauser, Jean-Pierre Bourquin, Irawati Kandela, Christine Mantis, Beatrix Ueberheide, Stephen Kelly, Alexandros Strikoudis, Pieter Van Vlierberghe, Clayton K. Collings, Elizabeth T. Bartom, Radhika Rawat, Lu Wang, Yoh-hei Takahashi, Emily J. Rendleman, Stacy A. Marshall, Steven Goosens, Geert Berx, Niels Vandamme, Sofie Peirs, Nobuko Hijiya, Nebiyu A. Abshiru, Young Ah Goo, Paul M. Thomas, Ivan Sokirniy, Hui Wang, Charles Grove, Jian Wu, Feng Wang, Andrew G. Volk, Megan R. Johnson, Kenneth K. Wang, Blanca T. Gutierrez-Diaz, Yixing Zhu, Kelly M. Arcipowski, Carlos A. Martinez, Qi Jin
Supplementary Table 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8040eda2b2a48513957d580845241b7e
https://doi.org/10.1158/1078-0432.22474511.v1
https://doi.org/10.1158/1078-0432.22474511.v1
Autor:
Panagiotis Ntziachristos, Ali Shilatifard, John D. Crispino, Suresh Kumar, Joseph Weinstock, Neil L. Kelleher, Giuseppe Basso, Benedetta Accordi, Maddalena Paganin, Silvia Bresolin, Valentina Serafin, Beat Bornhauser, Jean-Pierre Bourquin, Irawati Kandela, Christine Mantis, Beatrix Ueberheide, Stephen Kelly, Alexandros Strikoudis, Pieter Van Vlierberghe, Clayton K. Collings, Elizabeth T. Bartom, Radhika Rawat, Lu Wang, Yoh-hei Takahashi, Emily J. Rendleman, Stacy A. Marshall, Steven Goosens, Geert Berx, Niels Vandamme, Sofie Peirs, Nobuko Hijiya, Nebiyu A. Abshiru, Young Ah Goo, Paul M. Thomas, Ivan Sokirniy, Hui Wang, Charles Grove, Jian Wu, Feng Wang, Andrew G. Volk, Megan R. Johnson, Kenneth K. Wang, Blanca T. Gutierrez-Diaz, Yixing Zhu, Kelly M. Arcipowski, Carlos A. Martinez, Qi Jin
Supplementary Figs. 1-17 with legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5364415669a33c62d69399508aeb1fb1
https://doi.org/10.1158/1078-0432.22474517
https://doi.org/10.1158/1078-0432.22474517
Autor:
Panagiotis Ntziachristos, Ali Shilatifard, John D. Crispino, Suresh Kumar, Joseph Weinstock, Neil L. Kelleher, Giuseppe Basso, Benedetta Accordi, Maddalena Paganin, Silvia Bresolin, Valentina Serafin, Beat Bornhauser, Jean-Pierre Bourquin, Irawati Kandela, Christine Mantis, Beatrix Ueberheide, Stephen Kelly, Alexandros Strikoudis, Pieter Van Vlierberghe, Clayton K. Collings, Elizabeth T. Bartom, Radhika Rawat, Lu Wang, Yoh-hei Takahashi, Emily J. Rendleman, Stacy A. Marshall, Steven Goosens, Geert Berx, Niels Vandamme, Sofie Peirs, Nobuko Hijiya, Nebiyu A. Abshiru, Young Ah Goo, Paul M. Thomas, Ivan Sokirniy, Hui Wang, Charles Grove, Jian Wu, Feng Wang, Andrew G. Volk, Megan R. Johnson, Kenneth K. Wang, Blanca T. Gutierrez-Diaz, Yixing Zhu, Kelly M. Arcipowski, Carlos A. Martinez, Qi Jin
Purpose:T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive disease, affecting children and adults. Chemotherapy treatments show high response rates but have debilitating effects and carry risk of relapse. Previous work implicated NOTCH1 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0deb9c0766a8681e877d3398d1315853
https://doi.org/10.1158/1078-0432.c.6528809.v1
https://doi.org/10.1158/1078-0432.c.6528809.v1
Autor:
Rafael D. Melani, Vincent R. Gerbasi, Lissa C. Anderson, Jacek W. Sikora, Timothy K. Toby, Josiah E. Hutton, David S. Butcher, Fernanda Negrão, Henrique S. Seckler, Kristina Srzentić, Luca Fornelli, Jeannie M. Camarillo, Richard D. LeDuc, Anthony J. Cesnik, Emma Lundberg, Joseph B. Greer, Ryan T. Fellers, Matthew T. Robey, Caroline J. DeHart, Eleonora Forte, Christopher L. Hendrickson, Susan E. Abbatiello, Paul M. Thomas, Andy I. Kokaji, Josh Levitsky, Neil L. Kelleher
Publikováno v:
Science
Human biology is tightly linked to proteins, yet most measurements do not precisely determine alternatively spliced sequences or posttranslational modifications. Here, we present the primary structures of ~30,000 unique proteoforms, nearly 10 times m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ada067d85328d35da642f74ca2b072c
https://doi.org/10.1126/science.aaz5284
https://doi.org/10.1126/science.aaz5284