Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Paul M P, van Bergen En Henegouwen"'
Autor:
Matthieu R. Zeronian, Sofia Doulkeridou, Paul M. P. van Bergen en Henegouwen, Bert J. C. Janssen
Publikováno v:
BMC Molecular and Cell Biology, Vol 23, Iss 1, Pp 1-10 (2022)
Abstract Background The epidermal growth factor receptor (EGFR) is involved in various developmental processes, and alterations of its extracellular segment are associated with several types of cancers, in particular glioblastoma multiforme (GBM). Th
Externí odkaz:
https://doaj.org/article/97e603dd6d3c4ad188f414b157bf599d
Autor:
Marta Compte, Seandean L. Harwood, Jorge Martínez-Torrecuadrada, Gema Perez-Chacon, Patricia González-García, Antonio Tapia-Galisteo, Paul M. P. Van Bergen en Henegouwen, Aránzazu Sánchez, Isabel Fabregat, Laura Sanz, Juan M. Zapata, Luis Alvarez-Vallina
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Agonistic monoclonal antibodies (mAbs) targeting the co-stimulatory receptor 4-1BB are among the most effective immunotherapeutic agents across pre-clinical cancer models. However, clinical development of full-length 4-1BB agonistic mAbs, has been ha
Externí odkaz:
https://doaj.org/article/73fed565702c4bd49e60af922d155683
The architecture of EGFR’s basal complexes reveals autoinhibition mechanisms in dimers and oligomers
Autor:
Laura C. Zanetti-Domingues, Dimitrios Korovesis, Sarah R. Needham, Christopher J. Tynan, Shiori Sagawa, Selene K. Roberts, Antonija Kuzmanic, Elena Ortiz-Zapater, Purvi Jain, Rob C. Roovers, Alireza Lajevardipour, Paul M. P. van Bergen en Henegouwen, George Santis, Andrew H. A. Clayton, David T. Clarke, Francesco L. Gervasio, Yibing Shan, David E. Shaw, Daniel J. Rolfe, Peter J. Parker, Marisa L. Martin-Fernandez
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
To prevent ligand-independent dimerisation the epidermal growth factor receptor (EGFR) is autoinhibited by an extracellular dimer interaction. Here, the authors use several imaging technologies and simulations to provide structural insights on the in
Externí odkaz:
https://doaj.org/article/d8f1227aa2394ee08a80e9812006d6b2
Autor:
Sebas D. Pronk, Erik Schooten, Jurgen Heinen, Esra Helfrich, Sabrina Oliveira, Paul M. P. van Bergen en Henegouwen
Publikováno v:
Biomolecules, Vol 11, Iss 7, p 927 (2021)
Antibody-drug conjugates (ADCs) are currently used for the targeted delivery of drugs to diseased cells, but intracellular drug delivery and therefore efficacy may be suboptimal because of the large size, slow internalization and ineffective intracel
Externí odkaz:
https://doaj.org/article/95ef8bcfe44545c58131513ea26908a0
Autor:
Seandean Lykke Harwood, Ana Alvarez-Cienfuegos, Natalia Nuñez-Prado, Marta Compte, Sara Hernández-Pérez, Nekane Merino, Jaume Bonet, Rocio Navarro, Paul M. P. Van Bergen en Henegouwen, Simon Lykkemark, Kasper Mikkelsen, Kasper Mølgaard, Frederic Jabs, Laura Sanz, Francisco J. Blanco, Pedro Roda-Navarro, Luis Alvarez-Vallina
Publikováno v:
OncoImmunology, Vol 7, Iss 1 (2018)
The redirection of T cell activity using bispecific antibodies is one of the most promising cancer immunotherapy approaches currently in development, but it is limited by cytokine storm-related toxicities, as well as the pharmacokinetics and tumor-pe
Externí odkaz:
https://doaj.org/article/d8bd2b4e44d84e38968139ebfe1161aa
Autor:
Renée C. G. de Bruin, John P. Veluchamy, Sinéad M. Lougheed, Famke L. Schneiders, Silvia Lopez-Lastra, Roeland Lameris, Anita G. Stam, Zsolt Sebestyen, Jürgen Kuball, Carla F. M. Molthoff, Erik Hooijberg, Rob C. Roovers, James P. Di Santo, Paul M. P. van Bergen en Henegouwen, Henk M. W. Verheul, Tanja D. de Gruijl, Hans J. van der Vliet
Publikováno v:
OncoImmunology, Vol 7, Iss 1 (2018)
Though Vγ9Vδ2-T cells constitute only a small fraction of the total T cell population in human peripheral blood, they play a vital role in tumor defense and are therefore of major interest to explore for cancer immunotherapy. Vγ9Vδ2-T cell-based
Externí odkaz:
https://doaj.org/article/7c5a3a971c7f40ea88934267608977f3
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
The use of antibody-based therapeutics has proven very promising for clinical applications in cancer patients, with multiple examples of antibodies and antibody–drug conjugates successfully applied for the treatment of solid tumors and lymphomas. G
Externí odkaz:
https://doaj.org/article/bda872ec99b64d89a370db1dcdee3b4c
Autor:
Vida, Mashayekhi, Erik, Schooten, Paul M P, van Bergen En Henegouwen, Marta M, Kijanka, Sabrina, Oliveira
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2451
Nanobodies have recently been introduced to the field of photodynamic therapy (PDT) as a very promising strategy to target photosensitizers selectively to cancer cells. Nanobodies are known for their characteristic small size (15 kDa), high specifici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::aab095944e3ee11731209b5756cd3a46
https://pubmed.ncbi.nlm.nih.gov/35505026
https://pubmed.ncbi.nlm.nih.gov/35505026
Autor:
Piet Gros, Paul M. P. van Bergen en Henegouwen, Martin Lutz, Loes M. J. Kroon-Batenburg, Nicholas M. Pearce, Jip Manshande, Sofia Doulkeridou, Wouter Pos, Viviana Neviani, Katerina T. Xenaki, Wout Oosterheert
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68f7767ade0143944e02599102de7c41
https://doi.org/10.15252/rc.2022546203
https://doi.org/10.15252/rc.2022546203
Autor:
Chris D Emmerson, Els J van der Vlist, Myrthe R Braam, Peter Vanlandschoot, Pascal Merchiers, Hans J W de Haard, C Theo Verrips, Paul M P van Bergen en Henegouwen, Edward Dolk
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26299 (2011)
The polymeric immunoglobulin receptor (pIgR) ensures the transport of dimeric immunoglobulin A (dIgA) and pentameric immunoglobulin M (pIgM) across epithelia to the mucosal layer of for example the intestines and the lungs via transcytosis. Per day t
Externí odkaz:
https://doaj.org/article/47bd55659bc0464fa0a1c43a37e7cfc1